Author(s): Sundus Hameed Ahmed

Email(s): drsunduahmed@uomustansiriyah.edu.iq

DOI: 10.52711/0974-360X.2021.00891   

Address: Dr. Sundus Hameed Ahmed
College of Science, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
Objective: to find a modern technology to produce honey fortified naturally with lycopene extracted from tomatoes and to examine the bioactivity of the novel product. Materials and methods: Lycopene was extracted from tomatoes, tomatoes peels and tomatoes juice, the presence of lycopene and its concentrations was detected using UV-vis., the extracted lycopene was added to natural honey in different concentrations, the presence of lycopene in naturally fortified honey produced using HPLC technology was detected and active ingredients were detected using GC-MASS technology. Results: the tomatoes peels gave the highest concentration of lycopene compared to other parts, it gave a value of 0.52 relay factor (Rf) in addition to the appearance of a peak at a retention time (Rt) of 11.3 minutes corresponding to the standard lycopene top retention time, when performing a spectrophotometry between (300-600nm), pure lycopene gave three peaks at 440,460, 503nm wavelengths, and the retention coefficient (COD) is 0.98, 1.00, and 0.96 respectively. The effectiveness of enzymes (SOD) and (GPX) when treating with CCl4, it was found that the effectiveness of the two enzymes increased when using honey and lycopene in its various forms, as shown in results, a number of raw lycopene components appear in fortified honey such as; Ibuprofen, anti-inflammatory, sedative and substance, 1-Tetrazol-2-ylethanone, antimicrobial, anti-inflammatory, analgesic, anti-epileptic, anti-viral, antihypertensive, anti-malarial drug, anti- anxiety, depression, antihistamine, and 4H-Pyran-4 -one, 2,3-dihydro-3,5-dihydroxy-6-methyl which is an anti- cancer substance. Conclusion: the new honey fortified with lycopene shows a high activity against microbes, and also can be applied as anti-depression, anti-allergic and more.


Cite this article:
Sundus Hameed Ahmed. Bioactivity of Fortified Honey with lycopene extracted from tomatoes Solanum lycopersicum. Research Journal of Pharmacy and Technology. 2021; 14(10):5115-0. doi: 10.52711/0974-360X.2021.00891

Cite(Electronic):
Sundus Hameed Ahmed. Bioactivity of Fortified Honey with lycopene extracted from tomatoes Solanum lycopersicum. Research Journal of Pharmacy and Technology. 2021; 14(10):5115-0. doi: 10.52711/0974-360X.2021.00891   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-9


REFERENCES:
1.    Rahul C.Ranveer. Chapter 13 - Lycopene: A Natural Red Pigment. Natural and Artificial Flavoring Agents and Food Dyes, Handbook of Food Bioengineering, 2018, Pages 427-456. https://doi.org/10.1016/B978-0-12- 811518-3.00013-2
2.    Boileau TW-M, Boileau AC, Erdman JW. Bioavailability of all-trans and cis-isomers of lycopene. Exp Biol Med (Maywood), 2002; 227(10): 914- 919. doi: 10.1177/153537020222701012.
3.    Biswas S, Hwang JW, Kirkham PA, Rahman I. Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. Curr Med Chem. 2013; 20(12): 1496–1530.
4.    Choi S-K, Seo J-S. Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils. Nutr Res Pract. 2013; 7(1): 26–33. doi: 10.4162/nrp.2013.7.1.26
5.    W. Goodwin. Chemistry and Biochemistry of Plant Pigments (2nd Edition). Vol. 2, pp. 38- 165. Academic Press, London. 1976
6.    Olempska-Beer Z. Lycopene (Synthetic) Chemical and Technical Assessment    (CTA).    2006;    1-16.
www.fao.org/fileadmin/templates/agns/pdf/jecfa/cta/67/lycopene.pdf
7.    Touboul-Lundgren P, Jensen S, Drai J, Lindbæk M. Identification of cultural determinants of antibiotic use cited in primary care in Europe: a mixed research synthesis study of integrated design “Culture is all around us”. BMC Public Health. 2015; 15: 908. doi: 10.1186/s12889-015-2254-8.
8.    Britton G. Thin Layer Chromatography in Phytochemistry, 2008 - CRC Press, Boca Raton, FL. pp: 543-573.
9.    Nassar NMA, Vizzotto CS, Silva HL, Schvartz CA, et al. Potentiality of cassava cultivars as a source of carotenoids. J. Food Agri Env. 2005; 3: 33- 35.
10.    AOAC Official Method 2007.01 Pesticide Residues in Foods by Acetonitrile Extraction and Partitioning with Magnesium Sulfate Gas Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry First Action 2007
11.    Belle Ph, Kedi E, Meva FE, Kotsedi L, et al. Eco-friendly synthesis, characterization, in vitro and in vivo anti-inflammatory activity of silver nanoparticle-mediated Selaginella myosurus aqueous extract. International Journal of Nanomedicine. 2018; 13: 8537–8548.
12.    Jawad RM. Antimicrobial effect of bee honey on some pathogenic bacteria isolated from infected wounds in comparison to commonly used antibiotics. Journal of Basrah Researches (Sciences). 2011; 37(4A/15): 78-83.
13.    Anup A. Patil, Rajendra Doijad, Akshada Koparde. Renoprotective effect of Lycopene on Renal Functional and Histopathological changes in Gentamycin Induced Nephrotoxicity in Rats. Research J. Pharm. and Tech. 2020; 13(7): 3237-3240.
14.    Satish Y. Mane. Spectro Photometric Study of Lycopene Extract After Various Treatments of Fertilizers and Manure. Asian J. Research Chem. 2018; 11(3):607-609.
15.    Sheik Abdulazeez Sheriff, Thiruvengadam Devaki. Effect of Lycopene on General Clinical Parameters During D-galactosamine/Lipopolysaccharide (D-GalN/LPS) Induced Hepatitis in Rats. Research J. Pharm. and Tech. 5(3): Mar.2012; Page 398-403.
16.    Mahima Chauhan, Vandana Garg, Ghazala Zia, Rohit Dutt. Potential Role of Phytochemicals of Fruits and Vegetables in Human Diet. Research J. Pharm. and Tech 2020; 13(3):1587-1591.
17.    Navodit Goel, Anukrati Goel, Prabir Kumar Paul. A Strategy to Control Human Enteric Pathogens on Farm Fresh Tomatoes. Research J. Pharm. and Tech 2018; 11(6): 2408-2417.
18.    Monica Chopra, Asish Bhaumik, A. Gopi Reddy, P. Sravan Kumar, B. Srikant. Extraction and Isolation of Bioactive Molecule Lycopene from Water Melon and Evaluation of Anti Diabetic Activity against STZ Induced Rats.Research J. Pharm. and Tech. 2018; 11(1):101-106.
19.    D. A. Bhagwat, N. D. Patil, G. S. Patel, S. G. Killedar, H. N. More. Formulation and Evaluation of Herbal Lipstick using Lycopene Extracted from Solanum lycopersicum L. Research J. Pharm. and Tech. 2017; 10(4): 1060-1064.
20.    M. A. Fazeelath Banu, Karthikeyan Murthykumar, Dr. Dhanraj. Effect of Lycopene on Oral Lesions: A Short Review. Research J. Pharm. and Tech. 2016; 9(7):964-966.
21.    Sahana. K. Lycopene as an antioxidant and its medicinal uses. Research J. Pharm. and Tech. 8(8): August, 2015; Page 1043-1047.

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