Author(s):
P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta
Email(s):
hiiparul@gmail.com
DOI:
10.52711/0974-360X.2021.00960 
Address:
P. Agrawal1*, K. Mruthunjaya3, K. Goyal1, D. Ahuja1, M.K. Gupta2
1Research Scholar, Jayoti Vidyapeeth Women's University, Jaipur Rajasthan, India.
2Saint Soldier College of Pharmacy, Tonk, Rajasthan, India.
3J.S.S College of Pharmacy, J.S.S University, Mysore, Karnataka, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 10,
Year - 2021
ABSTRACT:
The present study was aimed to evaluate analgesic, anti-inflammatory and anti pyretic activity of methanolic extract and aqueous extract of leave of Rotula aquatica L. in mice and rats. The methanolic extract of R. aquatica L. leave at a dose of 200mg/kg body weight has shown significant analgesic, antipyretic and anti-inflammatory activity as compared to aqueous extract. The result of hot plate method indicated that the total methanolic extract showed significant increase (P<0.01) in reaction time at a 3,4and 6 hours comparable to the reference drug Pentazocin but lesser (P<0.05) after 2hr. The tail immersion and hot plate tests revealed that plant has high analgesic activity. Both tests showed highest degree of analgesia in methanolic extract compared to aqueous extract. The total methanolic extract of R.aquatica L. leave at the a dose of 200mg/kg body weight has shown significant (p<0.01) antipyretic activity as compared to aqueous extract, methanolic extract also found to have significant result in Carrageenin-induced paw oedema; suspect edmodeo faction may be due to possible inhibition of lipooxygenase pathway.
Cite this article:
P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta. Analgesic, Anti-inflammatory and Antipyretic Activity of Rotula aquatica Lour Leave. Research Journal of Pharmacy and Technology 2021; 14(10):5503-7. doi: 10.52711/0974-360X.2021.00960
Cite(Electronic):
P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta. Analgesic, Anti-inflammatory and Antipyretic Activity of Rotula aquatica Lour Leave. Research Journal of Pharmacy and Technology 2021; 14(10):5503-7. doi: 10.52711/0974-360X.2021.00960 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-78
REFERENCES AND NOTES:
1. A.L. Udupa, U.P. Rathnakarand S. Udupa. Anti- inflammatory, anti-pytrtic and analgesic effect of Tamarindus indica. Indian Drugs. 44(6):466- 470(2007).
2. Mamta K, Abhishek B, Rohit. Pharmacognostical evaluation on the root of Rotula aquatic lour. International Journal of Pharma and Bio Sciences. 2010;VI(2):01-04.
3. Gilhotra U, Christina AJM .Effect of Rotula aquatic lour on ethylene – glycol induced urolithias is inrat. Int .J .Drug Devand Res. 2011;3(1)273-280
4. Sivarajan, V. V, Indira Balachandran (1994). Ayurvedic Drugs and Their Plant Sources. New Delhi, India: Oxford and IBH Publishing Co. pp.358–359.
5. Christiana, A.J., M. Priyamole, P. Moorthy (July– August 2002). Studies on the antilithic effect of Rotula aquatic Lo urin male Wistar rats. Methods and Findings in Experimental and Clinical Pharmacology. 24(6):357–359.
6. Mukherjee P.K. Quality Control of Herbal Drugs: New Delhi, India, Business Horizone, 2002. Indian Pharmacopoeia. 1996. Vol II, Appendix 3.23, A47.
7. C.K Kokate. Practical Pharmacognosy.Nirali Prakashan;1994.
8. OECD [Organosation for Economic Co-opration and Development] 1992. Guideline 420: Acute oral toxicity–Fixed dose procedure, Paris: OECD.
9. Acosta SL, Muro LV, Sacerio AL, Pena AR, Okwei SN. Analgesic Properties of Caprariabi flora leaves aqueous extract. Fitoterapia. 2002;74: 686-8.
10. Udupa AL, Rathnakar UP, Udupa S. Anti- inflammatory, Anti-pyretic, Analgesic effect of Tamarindus indica. Indian drug, 2007; 44(6):466-0.
11. Vogel GH, Drug Discovery and Evaluation. 2nd Ed, Springer-Verlag Berlin Heidelberg. Germany; 2002.
12. Mandal SK, Mandal SC, Das AK, Tag H, Sur T. Antipyretic activity of Eupatorium adenophorum leaf extract. Ind. J. Nat. Prod 2005;21(1):6-8.
13. B.V. Owyele, S.B.Olaleye, J.M. Okeand R.A. Elegbe. Anti-inflammatory and Analgesic activity of Notho spondiasstaudtii. Nigerian journal of Physiological Sciences 19(1-2):102- 105(2004)
14. B.V. Owoyele, S.B. Olaleye, J. MO Keand R.A. Elegbe. Anti-inflammatory and Analgesic activity leaf extract of Land olphiao wariensis. Afr. J. Biomed. Res, 4:131-133(2001).
15. Lalitha KG, Sethuraman MG, and Rajkapoor B. Analgesic activity of Sarco stem mabrevistigma. Indian Drug. 2002; 39(10):541-2
16. S.M. Farook, W.C.Atlee, S. Kannan, S. Kumarand M.S. Davey. Assessment of Analgesic, Anti- Pyretic and Anti-inflammatory of Hydro- alcoholic fraction of Hemi desmus indicus root in experimental animals. Scholars Research Library, 3(1):448-453(2011)
17. S.R Swain, B.N.Sinhaand P.N Murthy. Comparative evaluation of Antipyretic and Analgesic activity of Rungi are pens Needs and Rung iapectinata L. Asian Journal of Pharmaceutical and Clinical Research. 4(2): 103-106(2011).
18. T.S. M. Saleem, S.D. Basha, G. Mahesh, P.V.S. Rami, N.S. Kumar and C.M. Chettv. Analgesic, Anti-Pyretic and Anti-inflammatory of Dietary Sesame Oil in Experimental Animal Models. Pharmacologia. 2(6):172-177(2011).
19. K.K Hullatti and M.S.Sharada.Comparative Antipyretic activity of Patha: An Ayurvedic drug. Pharmacognosy Magazine. 11(3):173- 175(2007).