Author(s): P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta

Email(s): hiiparul@gmail.com

DOI: 10.52711/0974-360X.2021.00960   

Address: P. Agrawal1*, K. Mruthunjaya3, K. Goyal1, D. Ahuja1, M.K. Gupta2
1Research Scholar, Jayoti Vidyapeeth Women's University, Jaipur Rajasthan, India.
2Saint Soldier College of Pharmacy, Tonk, Rajasthan, India.
3J.S.S College of Pharmacy, J.S.S University, Mysore, Karnataka, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
The present study was aimed to evaluate analgesic, anti-inflammatory and anti pyretic activity of methanolic extract and aqueous extract of leave of Rotula aquatica L. in mice and rats. The methanolic extract of R. aquatica L. leave at a dose of 200mg/kg body weight has shown significant analgesic, antipyretic and anti-inflammatory activity as compared to aqueous extract. The result of hot plate method indicated that the total methanolic extract showed significant increase (P<0.01) in reaction time at a 3,4and 6 hours comparable to the reference drug Pentazocin but lesser (P<0.05) after 2hr. The tail immersion and hot plate tests revealed that plant has high analgesic activity. Both tests showed highest degree of analgesia in methanolic extract compared to aqueous extract. The total methanolic extract of R.aquatica L. leave at the a dose of 200mg/kg body weight has shown significant (p<0.01) antipyretic activity as compared to aqueous extract, methanolic extract also found to have significant result in Carrageenin-induced paw oedema; suspect edmodeo faction may be due to possible inhibition of lipooxygenase pathway.


Cite this article:
P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta. Analgesic, Anti-inflammatory and Antipyretic Activity of Rotula aquatica Lour Leave. Research Journal of Pharmacy and Technology 2021; 14(10):5503-7. doi: 10.52711/0974-360X.2021.00960

Cite(Electronic):
P. Agrawal, K. Mruthunjaya, K. Goyal, D. Ahuja, M.K. Gupta. Analgesic, Anti-inflammatory and Antipyretic Activity of Rotula aquatica Lour Leave. Research Journal of Pharmacy and Technology 2021; 14(10):5503-7. doi: 10.52711/0974-360X.2021.00960   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-78


REFERENCES AND NOTES:
1.    A.L. Udupa, U.P. Rathnakarand S. Udupa. Anti- inflammatory, anti-pytrtic and analgesic effect of Tamarindus indica. Indian Drugs. 44(6):466- 470(2007).
2.    Mamta K, Abhishek B, Rohit. Pharmacognostical evaluation on the root of Rotula aquatic lour. International Journal of Pharma and Bio Sciences. 2010;VI(2):01-04.
3.    Gilhotra U, Christina AJM .Effect of Rotula aquatic lour on ethylene – glycol induced urolithias is inrat. Int .J .Drug Devand Res. 2011;3(1)273-280
4.    Sivarajan, V. V, Indira Balachandran (1994). Ayurvedic Drugs and Their Plant Sources. New Delhi, India: Oxford and IBH Publishing Co. pp.358–359.
5.    Christiana, A.J.,  M. Priyamole, P. Moorthy (July– August 2002). Studies on the antilithic effect of Rotula aquatic Lo urin male Wistar rats. Methods and Findings in Experimental and Clinical Pharmacology. 24(6):357–359.
6.    Mukherjee P.K. Quality Control of Herbal Drugs: New Delhi, India, Business Horizone, 2002. Indian Pharmacopoeia. 1996. Vol II, Appendix 3.23, A47.
7.    C.K Kokate. Practical Pharmacognosy.Nirali Prakashan;1994.
8.    OECD [Organosation for Economic Co-opration and Development] 1992. Guideline 420: Acute oral toxicity–Fixed dose procedure, Paris: OECD.
9.    Acosta SL, Muro LV, Sacerio AL, Pena AR, Okwei SN. Analgesic Properties of Caprariabi flora leaves aqueous extract. Fitoterapia. 2002;74: 686-8.
10.    Udupa AL, Rathnakar UP, Udupa S. Anti- inflammatory, Anti-pyretic, Analgesic effect of Tamarindus indica. Indian drug, 2007; 44(6):466-0.
11.    Vogel GH, Drug Discovery and Evaluation. 2nd Ed, Springer-Verlag Berlin Heidelberg. Germany; 2002.
12.    Mandal SK, Mandal SC, Das AK, Tag H, Sur T. Antipyretic activity of Eupatorium adenophorum leaf extract. Ind. J. Nat. Prod 2005;21(1):6-8.
13.    B.V. Owyele, S.B.Olaleye, J.M. Okeand R.A. Elegbe. Anti-inflammatory and Analgesic activity of Notho spondiasstaudtii. Nigerian journal of Physiological Sciences 19(1-2):102- 105(2004)
14.    B.V. Owoyele, S.B. Olaleye, J. MO Keand R.A. Elegbe. Anti-inflammatory and Analgesic activity leaf extract of Land olphiao wariensis. Afr. J. Biomed. Res, 4:131-133(2001).
15.    Lalitha KG, Sethuraman MG, and Rajkapoor B. Analgesic activity of Sarco stem mabrevistigma. Indian Drug. 2002; 39(10):541-2
16.    S.M. Farook, W.C.Atlee, S. Kannan, S. Kumarand M.S. Davey. Assessment of Analgesic, Anti- Pyretic and Anti-inflammatory of Hydro- alcoholic fraction of Hemi desmus indicus root in experimental animals. Scholars Research Library, 3(1):448-453(2011)
17.    S.R Swain, B.N.Sinhaand P.N Murthy. Comparative evaluation of Antipyretic and Analgesic activity of Rungi are pens Needs and Rung iapectinata L. Asian Journal of Pharmaceutical and Clinical Research. 4(2): 103-106(2011).
18.    T.S. M. Saleem, S.D. Basha, G. Mahesh, P.V.S. Rami, N.S. Kumar and C.M. Chettv. Analgesic, Anti-Pyretic and Anti-inflammatory of Dietary Sesame Oil in Experimental Animal Models. Pharmacologia. 2(6):172-177(2011).
19.    K.K Hullatti and M.S.Sharada.Comparative Antipyretic activity of Patha: An Ayurvedic drug. Pharmacognosy Magazine. 11(3):173- 175(2007).

Recomonded Articles:

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): S. R Suseem, Dhanish Joseph

DOI: 10.5958/0974-360X.2019.00067.2         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Hayat M. Mukhtar, Vandna Kalsi

DOI: 10.5958/0974-360X.2018.00395.5         Access: Open Access Read More

Author(s): Gopinath G, Thirumal M, P. R. Kumar

DOI: 10.5958/0974-360X.2020.00362.5         Access: Open Access Read More

Author(s): Fathima Mariyam Niyas

DOI: 10.5958/0974-360X.2015.00182.1         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Som K. Madhvi, Manik Sharma, Javaid Iqbal, Mohd Younis

DOI: 10.5958/0974-360X.2019.00785.6         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Yasmin A, Vijaya Bharathi R, Radha R

DOI: 10.5958/0974-360X.2019.00429.3         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Bharti Ahirwar, Dheeraj Ahirwar, Alpana Ram

DOI:         Access: Open Access Read More

Author(s): Praveen D, Ranadheer Chowdary P, Gandikota Thanmayi, Gangabathina Poojitha, Vijey Aanandhi M

DOI: 0.5958/0974-360X.2016.00047.0         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): B. Thawkar, M. Kale, M. Oswal, K. Maniyar, K. Kadam, S. Kamat

DOI: 10.5958/0974-360X.2016.00044.5         Access: Open Access Read More

Author(s): Sri Vasavi Reddy A, J. Suresh, Hemant K.S. Yadav, Apurva Singh

DOI: Not Available         Access: Open Access Read More

Author(s): G. Muthu Bhupathi, K. Padmalatha, Akkiraju Anusha, Abdul Rameeza, Makina Geethika Sravanthi, Sunnam Praneetha.

DOI: 10.5958/0974-360X.2016.00377.2         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags