Author(s): Indri Maharini, Ronny Martien, Akhmad Kharis Nugroho, Supanji, Adhyatmika

Email(s): ronnymartien@ugm.ac.id

DOI: 10.52711/0974-360X.2021.00956   

Address: Indri Maharini1,4, Ronny Martien2*, Akhmad Kharis Nugroho2, Supanji3, Adhyatmika2
1Program Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281 Indonesia.
2Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
3Department of Ophthalmology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.
4Departement of Pharmaceutics, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi 36361, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
Simple, easy, and economical UV spectrophotometric methods have been developed using simulated tear fluid (STF) solvent to determine levofloxacin hemihydrate (LEVH) levels in ocular nanoparticles, as indicated by the % entrapment efficiency. A maximum wavelength of levofloxacin at 288nm, with a 4.0-12.0µg/mL concentration, shows linear results with a correlation coefficient (r) of 0.9997 and an average % recovery of 99.920 –100.804%. The developed method is able to use for the analysis of levofloxacin hemihydrate in nanoparticle preparations.


Cite this article:
Indri Maharini, Ronny Martien, Akhmad Kharis Nugroho, Supanji, Adhyatmika. Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate. Research Journal of Pharmacy and Technology 2021; 14(10):5479-2. doi: 10.52711/0974-360X.2021.00956

Cite(Electronic):
Indri Maharini, Ronny Martien, Akhmad Kharis Nugroho, Supanji, Adhyatmika. Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate. Research Journal of Pharmacy and Technology 2021; 14(10):5479-2. doi: 10.52711/0974-360X.2021.00956   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-74


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DOI: 10.5958/0974-360X 

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