Author(s):
Mandeep Singh, D. N Prasad, Supriya Agnihotri
Email(s):
mandeepchadha7@gmail.com
DOI:
10.52711/0974-360X.2021.00889
Address:
Mandeep Singh1*, Dr. D. N Prasad2, Dr. Supriya Agnihotri3
1Research Scholar, IKG Punjab Technical University, Kapurthala, Jalandhar, Punjab, India.
2Shivalik College of Pharmacy, Nangal, Punjab, India.
3Chandigarh College of Pharmacy, Landran, Punjab, India.
*Corresponding Author
Published In:
Volume - 14,
Issue - 10,
Year - 2021
ABSTRACT:
Acridine and Triazols both are biologically active heterocyclic rings with cytotoxic potential. Triazolyl- acridine adduct attract the attention in the field of medicinal chemistry. Here we synthesized a series of triazolyl- acridine compounds by the appropriate procedures. Structure of all synthesized compounds was confirmed by the various spectroscopic methods e.g. FT-IR, proton NMR and Mass spectrograms. All synthesized triazolyl-acirdines compounds were assayed in-vitro for cytotoxic activity against MCF-7 (human breast adenocarcinoma cell line) and HT-29 (human colon adenocarcinoma cell line) cells by MTT- assay. All target compounds shows increasing activity in dose dependent manner. However MPSP-9 was sensitive against MCF-7 but compound MPSP-1 was most sensitive with minimum inhibitory concentration (IC50 value) against MCF-7 and HT-29 both cell lines.
Cite this article:
Mandeep Singh, D. N Prasad, Supriya Agnihotri. Synthesis, Characterization and Biological Evaluation of Novel Triazolyl - Acridine Derivatives as Cytotoxic Agents. Research Journal of Pharmacy and Technology. 2021; 14(10):5101-7. doi: 10.52711/0974-360X.2021.00889
Cite(Electronic):
Mandeep Singh, D. N Prasad, Supriya Agnihotri. Synthesis, Characterization and Biological Evaluation of Novel Triazolyl - Acridine Derivatives as Cytotoxic Agents. Research Journal of Pharmacy and Technology. 2021; 14(10):5101-7. doi: 10.52711/0974-360X.2021.00889 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-7
REFERENCES:
1. Mark W. Acridine: A Neglected Antibacterial Chromophore. Journal of Antimicrobial Chemotherapy. 2001; 47: 1–13.
2. Kumar R, Kaur M and Kumari M. Acridine: A Versatile Heterocyclic Nucleus. Acta Poloniae Pharmaceutica- Drug Research. 2012; 69: 3-9.
3. Srivastava A and Nizamuddin. Synthesis and Fungicidal Activity of Some Acridine Derivatives. Indian Journal of Heterocyclic Chemistry 2004; 13: 261-264.
4. Lerman LS. The Structure of the DNA-acridine complex. Proc. Natl. Acad. Sci. USA 1963; 49: 94–102.
5. Kreuzer KN. Bacteriophage T4: A Model System for Understanding the Mechanism of Type II Topoisomerase Inhibitors. BBA-Gene Struct. Expr. 1998; 1400: 339–347.
6. Vipul Singh, Arvind Kumar Singh, Rohit Tripathi, Preeti Mishra, Roopes Kumar Maurya. 1, 2, 4- Triazole Derivatives and its pharmacological activities. Asian J. Research Chem. 6(5): May 2013; Page 429-437.
7. Nachiket S. Dighe, Ravindra B. Saudagar, Ramesh S. Kalkotwar,
D.A. Jain. Pharmacological and Synthetic Profile of 1, 2, 4- Triazoles. Asian J. Research Chem. 4(12): Dec., 2011; Page 1807- 1811.
8. Michael JG, Debra AA, David JA, et al. Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl) oxazolidinones with expanded activity against the fastidious gram- negative organisms haemophilus influenzae and moraxellacatarrhalis. J Med Chem 2000; 43: 953–970.
9. Tozkoparan B, Kupeli E, Yesilada E, et al. synthesis and evaluation of analgesic/ anti-inflammatory and antimicrobial activities of 3-substituted- 1,2,4-triazole-5-thiones. Arzneimittelforschung. 2005; 55: 533.
10. Karali N, Capan G, Ergene N, et al. Synthesis, characterization and preliminary anticonvulsant evaluation of new indoline 2,3- dionederivatives. Sci Pharm 1997; 65: 277-287.
11. Passannanti A, Diana P, Barraja P, et al. Pyrrolo [2,3-d][1,2,3
]triazoles as Potential Antineoplastic Agents. Heterocycles 1998; 48: 1229-1235.
12. Sagar N, Venkateshwar RJ and Bhujanga RAKS. Synthesis and characterization of n-substituted-5-methyl-1-(4- methylphenyl)-1h- 1, 2, 3-triazole-4-carboxamide derivatives. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5: 89-94.
13. Ullmann F. On a new formation of diphenylamine derivatives. [machine translation]. Ber Dtsch Chem Ges. 1903; 36: 2382-84.
14. Jayakumar KN, John NA, Kimberly Y, et al. 4-N-, 4-S-, and 4-O- Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pKa on Activity vs Chloroquine Resistant Malaria. J Med Chem 2008; 51: 3466–3479.
15. Lalthazuala R and Ghanashyam B. A practical one-pot synthesis of azides directly from alcohols. J Chem Sci 2012; 124:687–691.
16. Fahmi H, Timothy L, Robert H, et al. Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates. J Am Chem Soc 2005; 127:210-216.
17. Burali Sanganna, A.R. Kulkarni. Antioxidant and Anti-colon cancer activity of fruit peel of Citrus reticulate essential oil on HT- 29 cell line. Research J. Pharm. and Tech. 6(2): Feb. 2013; Page 216-219.