Mandeep Singh, D. N Prasad, Supriya Agnihotri
Mandeep Singh1*, Dr. D. N Prasad2, Dr. Supriya Agnihotri3
1Research Scholar, IKG Punjab Technical University, Kapurthala, Jalandhar, Punjab, India.
2Shivalik College of Pharmacy, Nangal, Punjab, India.
3Chandigarh College of Pharmacy, Landran, Punjab, India.
Volume - 14,
Issue - 10,
Year - 2021
Acridine and Triazols both are biologically active heterocyclic rings with cytotoxic potential. Triazolyl- acridine adduct attract the attention in the field of medicinal chemistry. Here we synthesized a series of triazolyl- acridine compounds by the appropriate procedures. Structure of all synthesized compounds was confirmed by the various spectroscopic methods e.g. FT-IR, proton NMR and Mass spectrograms. All synthesized triazolyl-acirdines compounds were assayed in-vitro for cytotoxic activity against MCF-7 (human breast adenocarcinoma cell line) and HT-29 (human colon adenocarcinoma cell line) cells by MTT- assay. All target compounds shows increasing activity in dose dependent manner. However MPSP-9 was sensitive against MCF-7 but compound MPSP-1 was most sensitive with minimum inhibitory concentration (IC50 value) against MCF-7 and HT-29 both cell lines.
Cite this article:
Mandeep Singh, D. N Prasad, Supriya Agnihotri. Synthesis, Characterization and Biological Evaluation of Novel Triazolyl - Acridine Derivatives as Cytotoxic Agents. Research Journal of Pharmacy and Technology. 2021; 14(10):5101-7. doi: 10.52711/0974-360X.2021.00889
Mandeep Singh, D. N Prasad, Supriya Agnihotri. Synthesis, Characterization and Biological Evaluation of Novel Triazolyl - Acridine Derivatives as Cytotoxic Agents. Research Journal of Pharmacy and Technology. 2021; 14(10):5101-7. doi: 10.52711/0974-360X.2021.00889 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-7
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