Author(s): Aninditha Rachmah Ramadhiani, Galih Pratiwi, Eka Fitriani, Kurniawaty

Email(s): aninditha.rachmah.ar@gmail.com

DOI: 10.52711/0974-360X.2021.00948   

Address: Aninditha Rachmah Ramadhiani1*, Galih Pratiwi1, Eka Fitriani1, Kurniawaty2
1Departement of Pharmacy, STIKES ‘Aisyiyah Palembang, Sumatera Selatan 30152, Indonesia.
2Departement of Nursing, STIKES ‘Aisyiyah Palembang, Sumatera Selatan 30152, Indonesia.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
The use of stamina-enhancing drugs is now increasingly widespread. Continuous use of stamina medication can cause side effects such as insomnia, feeling nervous and emotional. Therefore, it is necessary to look for effective drugs, relatively low side effects, and relatively cheap prices. One of them is to use natural materials such as Tinospora crispa (L.) Hook stems. This study is to find out the tonic effect extract ethanol of Tinospora crispa stem against male mice with the Natatory Exhaustion Method. This research is an experimental study with a posttest matched control group design. Tonic effect test experiments were conducted using the Natatory Exhaustion Method. Test animals as many as 25 mice were divided into 5 groups, group I, II, III has given Tinospora crispa stem ethanol extract (100,200 and 400 mg/kg body weight). Group IV was given 100 mg/kg body weight of caffeine (positive control) and group V given 25 mL/kg body weight of Carboxymethylcellulose sodium 0.5 % (negative control). Test reserved per oral for 14 days. Test showing that administration 100, 200, and 400 mg/kg body weight of Tinospora crispa stem ethanol extract gave tonic effect on male mice. Mann-Whitney tests showed that the administration of Tinospora crispa stem ethanol extract doses of 100, 200, and 400 mg/kg body weight gave a tonic effect on male mice with significant value (p<0.05) compared to the administration of Carboxymethylcellulose sodium 0.5%, administration of 400 mg/kg body weight extract ethanol of Tinospora crispa stem has a tonic effect on mice which differs noticeably with the administration of caffeine 100 mg/kg body weight with significant value (p<0.05). The present investigation revealed that Tinospora crispa stem ethanol extract shows tonic effect by increasing swimming endurance on male mice.


Cite this article:
Aninditha Rachmah Ramadhiani, Galih Pratiwi, Eka Fitriani, Kurniawaty. Activity of Ethanol Extract of Tinospora crispa (L.) Hook in Increasing Swimming Endurance on Male Mice Using Natatory Exhaustion Method. Research Journal of Pharmacy and Technology 2021; 14(10):5439-2. doi: 10.52711/0974-360X.2021.00948

Cite(Electronic):
Aninditha Rachmah Ramadhiani, Galih Pratiwi, Eka Fitriani, Kurniawaty. Activity of Ethanol Extract of Tinospora crispa (L.) Hook in Increasing Swimming Endurance on Male Mice Using Natatory Exhaustion Method. Research Journal of Pharmacy and Technology 2021; 14(10):5439-2. doi: 10.52711/0974-360X.2021.00948   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-66


REFERENCES:
1.    Torres-harding S, Jason LA. What Is Fatigue? History and Epidemiology. In: Fatigue as a Window to the Brain. 2003.
2.    Warsinah, Baroroh HN, Harwoko. Phytochemical Analysis and Antioxidant Activity of Brotowali (Tinospora crispa L. Mier) Stem. Molekul. 2020;15(2):73–8.
3.    Choudhary N, Siddiqui MB, Khatoon S, Shazia B. Variation in Extract Yield in Different Parts of Tinospora cordifolia. Res J Pharmacol Pharmacodyn. 2014;6(1):1–4.
4.    Arundina I, Diyantri I, Budhy TI, Jit FY. The Effect of Brotowali Stem Extract (Tinospora Crispa) Towards Increasing Number of Lymphocytes in the Healing Process of Traumatic Ulcer on Diabetic Wistar Rat. J Int Dent Med Res. 2010;10(3):975–80.
5.    Tungpradit R, Sinchaikul S, Phutrakul S, Wongkham W, Chen S-T. Anti-Cancer Compound Screening and Isolation : Coscinium fenestratum , Tinospora crispa and Tinospora cordifolia. Chiang Mai J Sci. 2010;37(3):476–88.
6.    Ragavee A, Choedar T, Suman S, Asha Devi S. Evaluation of Bioactive Constituents and Antioxidant Activity of Mucilage Isolated from Tinospora Cordifolia. Res J Pharm Technol. 2018;11(7):2747–51.
7.    Venkatalakshmi P, Ragadevi M. Protective Effect of Tinospora cordifolia Linn., on Paracetamol and Alcohol Induced Hepatotoxicity in Albino Rats. Res J Pharm Technol. 2012;5(2):281–4.
8.    Biswasroy P, Panda S, Das C, Das D, Durga Madhab Kar GG. Tinospora cordifolia– A plant with Spectacular natural Immunobooster. Res J Pharm Tech. 2020;13(2):1035–8.
9.    Aminul H, M IAS, Mohammad S. Antimicrobial , Cytotoxicity and Antioxidant Activity of Tinospora crispa. J Pharm Biomed Sci. 2011;12(13):1–4.
10.    Pradhan D, Kar DM, Ghosh G. Bioassay-guided Fractionation of Anti-microbial principle from Ethanolic Extract of Tinospora cordifolia and its Characterization. Res J Pharm Tech. 2020;13(3):1415–22.
11.    Roy A, Sahu RK. Formulation and Development of Herbal Sunscreen Cream. Res J Top Cosmet Sci. 2014;5(I):12–4.
12.    Wei L, Tao L, Keji T. Flavonoids from mulberry leaves by microwave-assisted extract and anti-fatigue activity. African J Agric Res. 2009;4(9):898–902.
13.    Jin HM, Wei P. Anti-fatigue properties of tartary buckwheat extracts in mice. Int J Mol Sci. 2011;12(8):4770–80.
14.    Harwoko, Choironi NA. Quality Standardization of Brotowali (Tinospora crispa) Stem Extract. Tradit Med J. 2016;21(1):6–11.
15.    Gahlot K, Lal VK, Jha S. Total phenolic content, flavonoid content and in vitro antioxidant activities of Flemingia species (Flemingia chappar, Flemingia macrophylla and Flemingia strobilifera). Res J Pharm Technol. 2013;6(5):516–23.
16.    Fellah K, Amrouche A, Benmehdi H, Memmou F. Phenolic profile, antioxidants and kinetic properties of flavonoids and tannins fractions isolated from Prunus persica L. Leaves growing in Southwest Algeria. Res J Pharm Technol. 2019;12(9):4365–72.
17.    Roy A, Bhoumik D, Sahu RK, Dwivedi J. Phytochemical Screening and Antioxidant Activity of Sesbania grandiflora Leaves Extracts. Asian J Res Pharm Sci. 2014;4(1):16–21.
18.    Shiyan S, Arifin A, Amriani A, Herlina, Pratiwi G. Immunostimulatory Activity of Ethanol Extract from Calotropis gigantea L . Flower in Rats against Salmonella typhimurium Infection. Res J Pharm Technol. 2020;13(11):5244–50.
19.    Tary NLN, Sujono TA. Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain. Pharmacon J Farm Indones. 2018;18:14–8.
20.    Ribeiro JA, Sebastio AM. Caffeine and adenosine. J Alzheimer’s Dis. 2010;20:3–14.
21.    Sharma B, Gouda TS, Rao NV, Shalam M. A Study on Adaptogenic Activity of Stem Extracts of Tinospora malabarica (LAMK). Pharmacologyonline. 2007;1:349–58.
22.    Zyma VL, Miroshnichenko NS, Danilova VM, En Gin E. Interaction of Flavonoid Compounds with Contractile Proteins of Skeletal Muscle. Gen Physiol Biophys. 1988;7(2):165–75.
23.    Liu Y, Liu C. Antifatigue and increasing exercise performance of Actinidia arguta crude alkaloids in mice. J Food Drug Anal. 2016;30:1–8. Available from: http://dx.doi.org/10.1016/j.jfda.2016.03.001
24.    Narkhede AN, Jagtap SD, Nirmal PS, Giramkar SA, Nagarkar BE, Kulkarni OP, et al. Anti-Fatigue effect of Amarkand on Endurance Exercise Capacity in Rats. BMC Complement Altern Med. 2016;16(1):1–7. Available from: http://dx.doi.org/10.1186/s12906-016-0995-2

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Pande S. D., Wagh A.S., Bhagure L.B., Patil S.G., Deshmukh A.R.

DOI: 10.5958/0974-360X.2015.00070.0         Access: Open Access Read More

Author(s): Vandana Devi Sahu, Mukta Agrawal, Mukesh Sharma, Sandhya Chandrakar, Sujata Gupta, Garima Sharma, Kalyani Dewangan, Harsha Solanki, Manisha Majumdar, D. K. Tripathi, Amit Alexander, Ajazuddin

DOI: 10.5958/0974-360X.2016.00145.1         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): Loveleen Preet Kaur, Rajeev Garg, GD Gupta

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): V Rajesh Babu, Syeda Rana Nikhat, P Nivethithai, SH Areefulla

DOI: Not Available         Access: Open Access Read More

Author(s): A. Rajendra Kumar, N. J. Muthukumar, A. Faridha

DOI: 10.5958/0974-360X.2019.00081.7         Access: Open Access Read More

Author(s): Harsha Vardhani Kondepati, Girish Pai Kulyadi, Vamshi Krishna Tippavajhala

DOI: 10.5958/0974-360X.2018.00069.0         Access: Open Access Read More

Author(s): H.B. Pagar, U.P. Shinde, Y.S. Agrawal, S.D. Barhate, T.S. Luhade, R.O. Sonawane

DOI: Not Available         Access: Open Access Read More

Author(s): LP Hingmire, VN Deshmukh, DM Sakarkar

DOI:         Access: Open Access Read More

Author(s): Dharmendra Singh Sisodiya, Anuraj Soni, Ronak Patel, Uma Sankar Rao Majji, Praveen Khirwadkar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags