S. A. Khedkar, J. S. Patil, P. M. Sabale
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S. A. Khedkar1, J. S. Patil2, P. M. Sabale3
1Department of Pharmaceutical Chemistry, JNT University, Kakinada, Andhra Pradesh, India.
2Shivajirao Jondhale College of Pharmacy, Asangaon, Maharashtra, India.
3Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra, India.
Volume - 14,
Issue - 10,
Year - 2021
Drug design and development is an interactive process includes process like molecular docking which involves virtual analysis of the derivatives against the protein targets. COXS are the groups of enzymes which plays vital role in the human process. COX II is important enzyme involved in the inflammation and can act as potential target for development of the potent anti-inflammatory agents. Pyrimidine is one of the most utilized heterocyclic scaffolds for the development of therapeutic agents due to its role in the nucleic acid and proteins in the human body. The present communication deals with docking analysis of virtually designed 58 condensed pyrimidine derivatives as potential anti-inflammatory agents. The derivatives were designed and virtually screened via molecular docking against the COX-II crystal structure to identically the potential leads.
Cite this article:
S. A. Khedkar, J. S. Patil, P. M. Sabale. Virtual Analysis of Condensed Pyrimidine Derivatives as COX II Inhibitors Potential Anti-inflammatory Agents. Research Journal of Pharmacy and Technology 2021; 14(10):5423-6. doi: 10.52711/0974-360X.2021.00945
S. A. Khedkar, J. S. Patil, P. M. Sabale. Virtual Analysis of Condensed Pyrimidine Derivatives as COX II Inhibitors Potential Anti-inflammatory Agents. Research Journal of Pharmacy and Technology 2021; 14(10):5423-6. doi: 10.52711/0974-360X.2021.00945 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-63
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