Ganesh N. Sharma, Mayur R. Bhurat, Vijay M. Shastry, Birendra Shrivastava
Email ID Not Available
Dr. Ganesh N. Sharma1, Mayur R. Bhurat1*, Dr. Vijay M. Shastry2, Dr. Birendra Shrivastava1
1School of Pharmaceutical Sciences, SADTM campus, Jaipur National University, Jaipur, Rajasthan, 302017.
2Shastry Institute of Pharmacy, Erandol, Jalgaon, Maharashtra, 425109.
Volume - 14,
Issue - 10,
Year - 2021
The purpose of this research was to formulate and evaluate sustained release tablet by using novel polymer Remusatia vivipara tubers mucilage. Currently natural gums and mucilages are being used extensively comparable to synthetic drug release modifiers. Natural plant materials possess various advantages. These are very cheap, biocompatible, biodegradable and free from side effects. In present research Metoprolol succinate matrix tablets were prepared by using Remusatia vivipara tubers mucilage. For the formulation of sustained release matrix tablets, direct compression method was used. The formulated matrix tablets were then evaluated for thickness, diameter, hardness, weight variation, friability, drug content, swelling index, in-vitro drug release and stability studies. The formulated sustained release tablet passed all tests required. The dissolution profile of prepared tablets showed sustained release of drug up to 11 hours compared to the reference tablet formulation PROLOMET XI 100. Drug release data were then fitted in to release kinetic models such as zero order kinetic, first order kinetic, Higuchi model and Korsmeyer-Peppas model to study the release pattern of drug from each formulation. The prepared sustained release tablet formulation was compared with marketed formulation (reference formulation) for drug release study and factor f1 (difference factor) and f2 (similarity factor) were determined. From this study it can be concluded that as the concentration of Remusatia vivipara mucilage increases, there is decrease in the rate of drug release from the formulation. The best formulation was found to be F3 which consists of 20% Remusatia vivipara mucilage but did not give comparable drug release profile to the reference formulation with factor f1 69.4 % and f2 34.8%. But it can be said that Remusatia vivipara gum mucilage can be used in tablet formulation to give sustained release effect up to 10 hours or in combination with other natural gum mucilage it may enhance the release retardant effect of drug up to or more than 20 hrs. The release kinetic study showed that the prepared sustained release tablet formulation shows anomalous (non-fickian) diffusion pattern and follows both diffusion controlled and swelling controlled mechanisms for drug release.
Cite this article:
Ganesh N. Sharma, Mayur R. Bhurat, Vijay M. Shastry, Birendra Shrivastava. Formulation and Development of Metoprolol Succinate Sustained Release Matrix tablet using Remusatia vivipara tubers mucilage. Research Journal of Pharmacy and Technology 2021; 14(10):5405-0. doi: 10.52711/0974-360X.2021.00942
Ganesh N. Sharma, Mayur R. Bhurat, Vijay M. Shastry, Birendra Shrivastava. Formulation and Development of Metoprolol Succinate Sustained Release Matrix tablet using Remusatia vivipara tubers mucilage. Research Journal of Pharmacy and Technology 2021; 14(10):5405-0. doi: 10.52711/0974-360X.2021.00942 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-60
1. Sastry S, Nyshadham J and Fix J. Recent Technological advances in Oral drug delivery- a review. Pharmaceutical science & technology today. 2000; 3(4): 138-145.
2. Jaimini M and Kothari A. Sustained release matrix type drug delivery system: a review. Journal of Drug Delivery & Therapeutics. 2012; 2(6): 142-148.
3. Wikskard J, Andersson B, Kendall M and Stanbrook H. Pharmacokinetic consideration of formulation extended release metoprolol succinate in the treament of heart failure. Journal of cardiovascular Pharmacology, 2003; 41: 151-157.
4. Tripathi KD. Essentials of medical pharmacology. Jaypee brother’s medical publishers, New delhi. 2005.
5. Talukdar M, Michael A, Rambaut B and Kinget R. Comparative study on xanthan gum and hydroxyl propyl methyl cellulose as matrices for controlled release drug delivery and in vitro drug release behavior. Int. J. Pharm. 1996; 129: 233-244.
6. Sharada B, Basavaraj B, Bharath S, Deveswaran R and Madhavan V. Sustained release matrix tablets of indomethacin using hibiscus rosa-sinensis as release retardant. Schol. Res. Libr. 2012; 4 (1): 227-233.
7. Manandhar N. 1998. Native phytotherapy among the Raute tribes of Dadeldhura district, Nepal. Journal of Ethnopharmacology. 1998; 60: 199-206.
8. Bhurat M and Barhate S. Preliminary Evaluation of Remusatia vivipara tubers Mucilage as Gelling Agent. Research Journal of Pharmacy and Technology. 2013; 6(4): 1-5.
9. Shelke S, Aragade P and Sarode A. Preliminary Evaluation of Remusatia vivipara Mucilage as Tablet Binder. International Journal of PharmTech Research. 2011; 3(3): 1649-1651.
10. Bhurat M, Kawatikwar P and Kothari N. Evaluation of Remusatia vivipara tubers mucilage as an innovative suspending Agent, Inventi Impact: Novel Excipients, 2011: 15-18.
11. Jadhav R, Naik V and Kunure V. Physicochemical and Microscopical Properties of Starch from Tubers of Remusatia vivipara Schott. International Journal of Researches in Biosciences, Agriculture and Technology. 2017; V (3): 293-296.
12. Bhurat M and Kawatikwar P. Evaluation of Eulophia herbacea tubers mucilage as an innovative suspending agent. Journal of Pharmacy Research. 2012; 5(1): 321-323.
13. Gangurde H and Chordiya M. Formulation and evaluation of sustained release bioadhesive tablets of ofloxacin using 3 factorial design. Int J Pharm Investig. 2011; 1(3): 148-156.
14. Rita B and Suresh V. Formulation and evaluation of sustained release matrix tablets of Nifedipine. Annals of Clinical and Laboratory Research. 2015; 9: 1-6
15. Shinde S and Nehe P. Formulation, development and evaluation of sustained release matrix tablets of Ropinirole HSCl. International Journal of Pharma Sciences and Research. 2015; 6(8): 1075-1085.
16. Kshirsagar R and Jain V. Effect of different viscosity grade HPMC polymers on gastro-retentive drug delivery of metformin HCl. International Journal of Applied Pharmaceutics. 2009; 1(1): 44-50.
17. Sathyaraj A and Abhinav K. Formulation and evaluation of metoprolol succinate controlled release tablets using natural and synthetic polymer. International journal of pharmaceutical sciences and research 2012; Vol. 3(1): 247-256.
18. Wadher K, and Kakde R. Formulation and evaluation of a sustained release tablet of Metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers. Indian J Pharm Sci. 2011; 73(2): 208-215.
19. Parakh D and Patil M. Comparison of in vitro dissolution profiles of marketed Dicyclomine hydrochloride tablets. PHARMANEST an International Journal of Advances in Pharmaceutical Sciences. 2014; 5(3) 3: 2109-2119.
20. Yadav G and Bansal M. Multilayer tablets and their drug release kinetic models for oral controlled drug delivery system. Middle-East J. Sci. Res. 2013; 16 (6): 782-795.
21. Kumar U and Islam S. Assessment of once daily sustained release hydrophilic matrix tablet of carvedilol. Dhaka Univ. J. Pharm. Sci. 2017; 16(1): 43-53.
22. Oliveira P and Mendes C. Formulation development and stability studies of Norfloxacin extended-release matrix tablets. BioMed Research International. 2013: 1-9.