Mohammed Z. Ghadhyeb, Ali Atiyah Abid, Muhnad Dohan Abid
Mohammed Z. Ghadhyeb1*, Ali Atiyah Abid2, Muhnad Dohan Abid2
1Department of Chemistry, Faculty of Science, Kufa University, Najaf, Iraq.
2Ministry of Education, The General Directorate of Educational in Najaf Al-Ashraf, Najaf, Iraq.
Volume - 14,
Issue - 10,
Year - 2021
The present study describes synthesis, characterization (UV-Vis, FT-IR, 1HNMR, CHN analysis and melting point) and biological activity of new substituted benzimidazolium salt and their N-heterocycliccarbene (NHC) respective Ag(I) and Pd(II) complexes. The benzimidazole reacted with acetamide substituents at 90oC to form variety substituted of benzimidazolium salt to yield unsymmetrically substituted salt. Silver(I) complex was synthesized from the reaction of unsymmetrical substituted benzimidazolium salt with Ag2O using in-situ deprotonation technique to give derived structures in good yield.The use of Ag(I)-NHC complex is as transfer reagents by using the transmetallation technique to prepare respective Pd(II)-NHC. The biological activity. of the formed substituted benzimidazolium salts, Ag(I) and Pd(II) complexes was estimated against some bacteria strains S. aureus. And E.coli .The Ag(I)showed good activity while their corresponding salt and Pd(II)-NHC complex show less activity.
Cite this article:
Mohammed Z. Ghadhyeb, Ali Atiyah Abid, Muhnad Dohan Abid. Bridge, N-heterocyclic Carbene Complexes with Silver (I) and Palladium (II): Synthesis and Biological Activity. Research Journal of Pharmacy and Technology 2021; 14(10):5366-0. doi: 10.52711/0974-360X.2021.00936
Mohammed Z. Ghadhyeb, Ali Atiyah Abid, Muhnad Dohan Abid. Bridge, N-heterocyclic Carbene Complexes with Silver (I) and Palladium (II): Synthesis and Biological Activity. Research Journal of Pharmacy and Technology 2021; 14(10):5366-0. doi: 10.52711/0974-360X.2021.00936 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-54
1. H. V. Huynh, The Organometallic Chemistry of N-heterocyclic Carbenes. 2017.
2. M. Fèvre, J. Pinaud, Y. Gnanou, J. Vignolle, and D. Taton, “N-Heterocyclic carbenes (NHCs) as organocatalysts and structural components in metal-free polymer synthesis,” Chem. Soc. Rev., vol. 42, no. 5, pp. 2142–2172, 2013, doi: 10.1039/c2cs35383k.
3. T. Cantat, N. Mézailles, A. Auffrant, and P. Le Floch, “Bis-phosphorus stabilised carbene complexes,” Journal of the Chemical Society. Dalton Transactions. 2008, doi: 10.1039/b717600g.
4. W. A. Herrmann, “N-heterocyclic carbenes: A new concept in organometallic catalysis,” Angewandte Chemie - International Edition. 2002, doi: 10.1002/1521-3773(20020415)41:8<1290::AID-ANIE1290>3.0.CO;2-Y.
5. T. Weskamp, V. P. W. Bhm, and W. A. Herrmann, “synthesis *,” vol. 600, pp. 12–22, 2000.
6. C. M. Crudden and D. P. Allen, “Stability and reactivity of N-heterocyclic carbene complexes,” Coord. Chem. Rev., vol. 248, no. 21–24, pp. 2247–2273, 2004, doi: 10.1016/j.ccr.2004.05.013.
7. N. C. Kasuga, A. Sugie, and K. Nomiya, “Syntheses, structures and antimicrobial activities of water-soluble silver(I)-oxygen bonding complexes with chiral and racemic camphanic acid (Hca) ligands,” Dalt. Trans., 2004, doi: 10.1039/b411859f.
8. S. Ray et al., “Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes,” J. Am. Chem. Soc., vol. 129, no. 48, pp. 15042–15053, 2007, doi: 10.1021/ja075889z.
9. X. Wang, S. Liu, and G.-X. Jin, “ Preparation, Structure, and Olefin Polymerization Behavior of Functionalized Nickel(II) N-Heterocyclic Carbene Complexes † ,” Organometallics, 2004, doi: 10.1021/om049467z.
10. J. C. Garrison and W. J. Youngs, “Ag(I) N-heterocyclic carbene complexes: Synthesis, structure, and application,” Chemical Reviews. 2005, doi: 10.1021/cr050004s.
11. M. V. Baker et al., “Cationic, linear Au(I) N-heterocyclic carbene complexes: Synthesis, structure and anti-mitochondrial activity,” Dalt. Trans., 2006, doi: 10.1039/b602560a.
12. A. A. Danopoulos, S. Winston, and M. B. Hursthouse, “C-H activation with N-heterocyclic carbene complexes of iridium and rhodium,” J. Chem. Soc. Dalt. Trans., 2002, doi: 10.1039/b205617h.
13. A. M. Magill et al., “Palladium(II) complexes containing mono-, bi- and tridentate carbene ligands. Synthesis, characterisation and application as catalysts in C-C coupling reactions,” J. Organomet. Chem., 2001, doi: 10.1016/S0022-328X(00)00720-8.
14. R. A. Haque, M. Z. Ghdhayeb, A. W. Salman, S. Budagumpi, M. B. Khadeer Ahamed, and A. M. S. Abdul Majid, “Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies,” Inorg. Chem. Commun., vol. 22, pp. 113–119, 2012, doi: 10.1016/j.inoche.2012.05.037.