Author(s): Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah

Email(s): rathi.sanjesh@gmail.com

DOI: 10.52711/0974-360X.2021.00935   

Address: Sanjesh Rathi*, Sohansinh Vaghela, Raj Shah, Shrenik Shah
Department of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences and Research, Dhanap, Gujarat 382355.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
The present research work done with an objective of preparation and evaluation of floating tablets of Febuxostat drug with Hydroxypropylenemethyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.


Cite this article:
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935

Cite(Electronic):
Sanjesh Rathi, Sohansinh Vaghela, Raj Shah, Shrenik Shah. Formulation and Evaluation of Gastroretentive Floating Tablets of Febuxostat. Research Journal of Pharmacy and Technology 2021; 14(10):5359-5. doi: 10.52711/0974-360X.2021.00935   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-53


REFERENCES:
1.    Arora S, Ali J, Ahuja A, Khar R, Baboota S. “Floating drug delivery systems: a review.” AAPS Pharm. Sci. Tech, 2005, 06(03), 1-8.
2.    Yeole P, Khan S, Patel V, “Floating drug delivery system: need and development.” Indian Journal of Pharmaceutical Science, 2005, 67(3), 265-71.
3.    Talukder R, Fassihi R. “Gastroretentive delivery system: A mini review.” Drug Dev Ind Pharm, 2004, 30 (10), 1019-28.
4.    Singh B, Kim K, “Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention.” J Con Rel,2000, 63, 235-59.
5.    Rabiah B, Asmat M, Tabasum A, Saeema F, Nisar A, “Floating Oral In-Situ Gel: A Review”, Journal of Drug Delivery and Therapeutics, 2019, 9(2), 442-448.
6.    Vyas S, Khar R, Gastroretentive systems In Controlled drug Delivery. Vallabh Prakashan, Delhi, India. 2006, 197-217.
7.    Talukder R, Fissihi R. “Gastroretentive Delivery Systems: A Mini review”, Drug Dev. Ind. Pharm, 2004, 30, 1019-1028.
8.    Parmar P, Pande S, Shah S, Sonara N. “Floating drug delivery system: A novel approach to prolong gastric retention.”World J Pharmacy Pharm Sci, 2014, 3(4), 418-444.
9.    Gout disease Information, October 2019: -https://www.mayoclinic.org/diseases-conditions/ gout/symptoms-causes/syc-20372897.
10.    Febuxostat Drug Information, October 2019: -https://pubchem.ncbi.nlm.nih.gov/compound/ Febuxostat.

Recomonded Articles:

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Alai M.S., Shinkar D.M., Saudagar R.B.

DOI: 10.5958/0974-360X.2017.00646.1         Access: Open Access Read More

Author(s): K. Gnanaprakash, K.B. Chandhra Shekhar, C. Madhu Sudhana Chetty

DOI: Not Available         Access: Open Access Read More

Author(s): Mohini Upadhye, Preeti Badoni, Smita More

DOI: Not Available         Access: Open Access Read More

Author(s): Pavani M., D.P. Mastan Yadav, Manikanta Kumar A., K.S. Manjunath Shetty

DOI: Not Available         Access: Open Access Read More

Author(s): Pare A, Yadav SK, Patil UK

DOI:         Access: Open Access Read More

Author(s): Tom Damien, Someshwara Rao B., Ashok Kumar P., Amith S. Yadav, Suresh V. Kuikarni

DOI:         Access: Open Access Read More

Author(s): S Vijaya Kumar, Manoj Kumar Deka, Manish Bagga, M Sasi Kala, Guru Sharan

DOI: Not Available         Access: Open Access Read More

Author(s): Veeranagoud Biradar, Jeevan Matada Basavarajaiah, Myat Thu Thu Win, Leneena Gudugunta, Suresh KV , Sathiyavathi Mahendra Kumar, Neeraja Turagam, Lavanya Priya

DOI: 10.5958/0974-360X.2019.00622.X         Access: Open Access Read More

Author(s): Palak Agrawal, Ajazuddin, Tripti Banjare, Swapnil Gupta, Akansha Bhandarkar, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Aditi Bhatt, Kailash Sahu, Deeksha Dewangan, Hemlata Thapa, Deepika, Gyanesh Sahu, Mukesh Sharma, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0974-360X.2018.00517.6         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): Jahnabi Sarmah, Ananta Choudhury

DOI: 10.5958/0974-360X.2020.00724.6         Access: Open Access Read More

Author(s): Devendiran B, Mothilal M, Damodharan N

DOI: 10.5958/0974-360X.2020.00533.8         Access: Open Access Read More

Author(s): Kailash Sahu, Amit Alexander, Hemlata Thapa, Tripti Banjare, Palak Agrawal, Akansha Bhandarkar, Aditi Bhatt, Swapnil Gupta, Hemlata Sahu, Shradha Devi Diwedi, Pankaj Sahu, Siddharth Kumar Sahu, Pooja Yadav, Deeksha Dewangan, Deepika, Hemant Ramchandra Badwaik, Mukesh Sharma, D. K. Tripathi, Ajazuddin

DOI: 10.5958/0974-360X.2018.00386.4         Access: Open Access Read More

Author(s): Syed Zia Ul Quasim1*, Abdul Naveed1, Shaik Ali Abbas1 and Mohd Abdul Irfan2

DOI: Not Available         Access: Open Access Read More

Author(s): Pare A, Yadav SK, Patil UK

DOI:         Access: Open Access Read More

Author(s): Bharadhwaj Ramesh Iyer, N. Damodharan

DOI: 10.5958/0974-360X.2019.00160.4         Access: Open Access Read More

Author(s): Srujana Kumari D., Balasubramaniam V., Velrajan G., Deepthi N., Sushma R

DOI: Not Available         Access: Open Access Read More

Author(s): Varma MM, Suneetha S, Raju DB

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags