Author(s): Surbhi Rohilla, Dinesh Chandra Bhatt

Email(s): surbhiraman.rohilla22@gmail.com

DOI: 10.52711/0974-360X.2021.00933   

Address: Surbhi Rohilla*, Dinesh Chandra Bhatt
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana - 125001, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
In the present investigation an attempt was made to focus on the stability aspects of itraconazole hollow microsphere at refrigerated condition, room temperature and at accelerated condition. In stability studies, more emphasis given on the effect of different temperature conditions on appearance, % drug content, % buoyancy and % drug release of formulation over a period of 6 months. Apart from above studies, SEM and FTIR analysis was done to determine any change in morphology or chemical structure. The results showed non-significant changes in pharmaceutical properties. From result findings, it can be concluded that the itraconazole hollow microspheres are stable formulation to sustain the drug in upper GIT for prolonged period of time.


Cite this article:
Surbhi Rohilla, Dinesh Chandra Bhatt. Stability studies of Hollow Microspheres at Refrigerated, Normal and Accelerated Conditions. Research Journal of Pharmacy and Technology 2021; 14(10):5351-4. doi: 10.52711/0974-360X.2021.00933

Cite(Electronic):
Surbhi Rohilla, Dinesh Chandra Bhatt. Stability studies of Hollow Microspheres at Refrigerated, Normal and Accelerated Conditions. Research Journal of Pharmacy and Technology 2021; 14(10):5351-4. doi: 10.52711/0974-360X.2021.00933   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-51


REFERENCES:
1.    ICH-International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use, Stability testing: photostability testing of new drug sub-stances and products, Q1B; 1996.
2.    World Health Organization, Annex 2: Stability Testing of Active Pharmaceutical Ingredients and Finished Pharmaceutical Products, vol. 953 of WHO Technical Report Series; 2009.
3.    Shah P, Rajshree M, Rane Y. Stability testing of pharmaceuticals-A global perspective. J. Pharm. Res. 2007; 6(1): 1-9.
4.    Kushwaha P. Significance of Stability Studies on Degradation Product. Research J. Pharm. and Tech. 2009; 2(4): 621-627
5.    Carstensen JT,  Rhodes CT. Rational policies for stability testing. Clin. Res. Regul. Aff. 1993 Jan 1; 10(3): 177-85.
6.    Rohilla S, Bhatt D C, Ahalwat S. Effect processing variables on the characteristics of itraconazole hollow microspheres. Int. J. App. Pharm. 2019; 11(6): 108-115.
7.    Faizi SM, Rathi PN, Tajane SV, Burghate RM, \ Wasankar SR . Drug Delivery to Absorption Window through Floating Microspheres: A Review. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 135-142 .
8.    Firke S, Roge A, Ghiware N, Dhoot SB, Vadwalkar SM. Floating Microspheres as Gastro-Retentive Drug Delivery System: A Review. Research J. Pharm. and Tech. 2013; 6(12): 1452-1458.
9.    Kawashima Y, Niwa T, Takeuchi H, Hino T,  Ito Y. Preparation of multiple unit hollow microspheres (microballoons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (in vivo). J. Control. Release. 1991; 16(3): 279-289.
10.    Sato Y, Kawashima Y, Takeuchi H, Yamamoto H. In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. Eur. J. Pharm. Biopharm. 2004; 57(2): 235-243.
11.    Stability Testing Guidelines, Stability Testing of New Drug Substances and Products. ICH—Technical Coordination, EMEA, London; 2003.
12.    Bajaj S, Singla D, Sakhuja N. Stability testing of pharmaceutical products. J. App. Pharm. Sci. 2012; 2(3): 129-138.
13.    Rohilla S, Bhatt DC, Ahalwat S. Fabrication of potential gastroretentive microspheres of itraconazole for stomach-specific delivery: Statistical optimization and in vitro evaluation. J. App. Pharm. Sci. 2020; 10(03):119-27.
14.    Najmuddin M, Ahmed A, Shelar S, Patel V,  Khan T. Floating microspheres of ketoprofen: formulation and evaluation. Int. J. Pharm. Pharm. Sci. 2010; 2(2): 83-87.
15.    Gawade P, Agrawal S. Design and characterization of eudragit coated Chitosan microspheres of deflazacort for colon targeting. J. Pharm. Res. 2012; 5(9): 4867-70.
16.    Jain SK, Agrawal GP, Jain NK. Floating microspheres as drug delivery system: newer approaches. Curr. Drug Deliv. 2008; 5(3): 220-223.

Recomonded Articles:

Author(s): S. Valarmathi, M. Senthil Kumar, Vignesh Sharma, Mohamed Imran, Mohanasundaram

DOI: 10.5958/0974-360X.2020.00043.8         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Author(s): Peethala Prathyusha, Raja Sundararajan, Palyam Bhanu, Mathrusri Annapurna Mukthinuthalapati

DOI: 10.5958/0974-360X.2020.00507.7         Access: Open Access Read More

Author(s): Vijayalakshmi. S , Disalva. X, Chittaranjan Srivastava, Arun A

DOI: 10.5958/0974-360X.2019.00520.1         Access: Open Access Read More

Author(s): Yarnykh T. G., Kotvitska A. A., Tykhonov A. I., Rukhmakova O. A.

DOI: 10.5958/0974-360X.2020.00614.9         Access: Open Access Read More

Author(s): Nuha Rasheed, Syed Abdul Rahman, Samreen Hafsa

DOI: 10.5958/0974-360X.2020.00306.6         Access: Open Access Read More

Author(s): Suha Alnaeb, Youssef Alahmad, Saleh Trefi

DOI: 10.5958/0974-360X.2019.01035.7         Access: Open Access Read More

Author(s): Dhara Parekh, Pankaj Kapupara, Ketan Shah

DOI: dharaparekh92@gmail.com         Access: Open Access Read More

Author(s): R. P. Bhole, S. R. Jagtap, K. B. Chadar, Y. B. Zambare

DOI: 10.5958/0974-360X.2020.00189.4         Access: Open Access Read More

Author(s): Kishore Manoharan, Navya Ajitkumar Bhaskaran, Lalit Kumar

DOI: 10.5958/0974-360X.2019.01070.9         Access: Open Access Read More

Author(s): Trilokchandran. B, Vijayakumar G, Thippareddy K S

DOI: 10.5958/0974-360X.2019.00612.7         Access: Open Access Read More

Author(s): R Deveswaran, S Bharath, BV Basavaraj, Sindhu Abraham, Sharon Furtado, V Madhavan

DOI:         Access: Open Access Read More

Author(s): Bahubali N. Patil, Vamshi Krishna Tippavajhala, Girish Pai K

DOI: 10.5958/0974-360X.2019.00140.9         Access: Open Access Read More

Author(s): Vandana Devi Sahu, Mukta Agrawal, Mukesh Sharma, Sandhya Chandrakar, Sujata Gupta, Garima Sharma, Kalyani Dewangan, Harsha Solanki, Manisha Majumdar, D. K. Tripathi, Amit Alexander, Ajazuddin

DOI: 10.5958/0974-360X.2016.00145.1         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Prabhakar Panzade, Prashant K Puranik

DOI: Not Available         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags