Author(s): Rajani Thoutreddy, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Chakravarthi Guntupalli, Alekhya Mudigonda

Email(s): rajanithoutreddy28@gmail.com

DOI: 10.52711/0974-360X.2021.00922   

Address: Rajani Thoutreddy1,2*, Umasankar Kulandaivelu1, GSN Koteswara Rao1, Rajasekhar Reddy Alavala1, Chakravarthi Guntupalli1, Alekhya Mudigonda2
1K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India.
2Vaagdevi College of Pharmacy, Kakatiya University, Kishanpura, Hanamkonda, Telangana, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
Topical delivery of local anaesthetic drugs such as Lidocaine HCl using carriers and novel nanotechnology can enhance effective drug permeation through the skin into deeper layers and exhibit desirable duration of action. The present study was aimed to formulate and evaluate Lidocaine HCl loaded cubosomes (LHLCs) for sustained therapeutic topical action. Cubosomes emanated as favourable means for the delivery of the drug. LHLCs were prepared by top-down technique using lipid and polymer. Eight formulations of LHLCs were prepared using different concentrations of glyceryl monooleate (GMO) and Poloxamer 407 (P-407). Local anaesthetics create loss of sensation in particular region of the body by inhibiting impulse generation and propagation. Lidocaine HCl is most commonly used amino amide local anaesthetic. It is used as local, topical, intravenous, epidural, peripheral and spinal anaesthesia. The prepared cubosomal dispersions were evaluated to determine surface morphology, particle size, poly dispersibility index (PDI), zeta potential, entrapment ability, tissue distribution studies, and in vitro drug release studies. Scanning Electron Microscopic analysis confirmed that drug was encapsulated in bicontinuous structure. The maximum entrapment efficiency was found to be 89.85±1.1% with vesicle size as 228±2.1nm, charge as -5.68±2.7, PDI as 0.295 and 98.83%± 0.12 in vitro drug release at the end of 12 hr for F7 formulation, which was confirmed as optimized cubosomal dispersion.


Cite this article:
Rajani Thoutreddy, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Chakravarthi Guntupalli, Alekhya Mudigonda. Fabrication and Evaluation of Lidocaine Hydrochloride loaded Cubosomes. Research Journal of Pharmacy and Technology. 2021; 14(10):5288-2. doi: 10.52711/0974-360X.2021.00922

Cite(Electronic):
Rajani Thoutreddy, Umasankar Kulandaivelu, GSN Koteswara Rao, Rajasekhar Reddy Alavala, Chakravarthi Guntupalli, Alekhya Mudigonda. Fabrication and Evaluation of Lidocaine Hydrochloride loaded Cubosomes. Research Journal of Pharmacy and Technology. 2021; 14(10):5288-2. doi: 10.52711/0974-360X.2021.00922   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-40


REFERENCES:
1.    Nagdev CH, Srinivas RD, Venkatesh P, Hepcykalarani D, Prema R. A Review on Transdermal Drug Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2020; 10 (2): 109-114.
2.    Bhakti RC, Swapnil TD, Rohith DS, Swati SK, Sagar VM. Transdermal Drug Delivery System: A review. Research Journal of Pharmaceutical Dosage forms and Technology. 2013; 5(2): 65-69.
3.    Susan H. Lipid based nano-delivery systems for skin delivery of drugs and bioactives. Frontiers in Pharmacology. 2015; 6: 1-5.
4.    Manvir A, Rana AC, Nimrata S. Comparative potential of vesicular carrier for Transdermal Drug Delivery. Research Journal of Pharmacy and Technology. 2012; 5(3): 302-306.
5.    Pradnya MK, Manish MR, Dipti GP. Controlled Drug Delivery System. Asian Journal of Pharmacy and Technology. 2018; 8(3): 161-164.
6.    Charles BB, Anjali K and Kenneth D. Local Anesthetics. In Basics of Anesthesia, Edited byManuel P and Ronald DM, Elsevier, Canada. 2018; 7th ed: pp.139-148.
7.    Hasnain MS, Rishishwar P, Ali S. Use of Cashew bark exudate gum in the preparation of 4% Lidocaine Hcl Topical gels. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9(8): 146-150.
8.    Robert MJ, Magdalena R, Pawel M, Natalia L. Local anesthetics and advances in their administration- an overview. Journal of Pre-Clinical and Clinical Research. 2017; 11(1): 94-101.
9.    Becker DE, Reed KL. Local anesthetics: review of pharmacological considerations. Anesthesia Progress. 2012; 59(2): 90-102.
10.    Zhao X, Sun Y, Li Z. Topical anaesthesia therapy using lidocaine loaded nano structured lipid carriers: Tocopheryl polyethyelene glycol 1000- succinate modified transdermal delivery system. Drug Design Development and Therapy. 2018; 12: 4231-4240.
11.    Weinberg L, Peake B, Tan C, Nikfarjam M. Pharmacokinetics and pharmacodynamics of lignocaine: A review. World Journal of Anesthesiology. 2015; (2):17-29.
12.    NavinTaj S, Muzib YI. A review on liquid crystalline nanoparticles (cubosomes):emerging nanoparticulate drug carrier. International Journal of Current Pharmaceutical Research. 2020; 12(1): 5-9.
13.    Deepak P and Dharmesh S. Cubosomes: A Sustained Drug Delivery Carrier. Asian Journal of Research in Pharmaceutical Sciences. 2011; 1(3): 59-62.
14.    Salah S, Mahmoud AA, Kamel AO. Etodolac transdermal cubosomes for the treatment of rheumatoid arthritis: ex vivo permeation and in vivo pharmacokinetic studies. Drug delivery. 2017; 24(1): 846-856.
15.    Ali Z, Sharma PK, Warsi MH. Fabrication and evaluation of ketorolac loaded cubosome for ocular drug delivery. Journal of Applied Pharmaceutical Science. 2016; 6(09): 204-208.
16.    Pavani S, Mounika K, Naresh K. Formulation and Evaluation of Acyclovir Microspheres. Iraqui Journal of Pharmaceutical Sciences. 2018; 27(1): 1-7.
17.    Alaa EE, Salwa S, Mahmoud G. Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in- vivo phramcodynamic study. Journal of Drug Delivery Science and Technology. 2019; 52: 236-247.
18.    Purushothaman P, Umar Faruk sha A and Vetrichelvan T. Formulation development and Evaluation of immediate and sustained release Bilayer Tablets Containing Amitriptyline HCl and Pregabalin for the treatment of Neuropathic Pain. Asian Journal of Pharmacy and Technology. 2017; 7(3), 127-136.
19.    Gondkar SB, Neha R, Patil R, Saudagar B. Formulation, Development and Characterization of Etodolacloaded Transethosmes for Transdermal Delivery. Research Journal of Pharmacy and Tehnology. 2017; 10(9): 3049- 3057.
20.    Bachhav JK, Bhairav BA, Saudagar RB. Formulation and evaluation of topical emulgel of ketoconazole by cubosomal technique. World Journal of Pharmaceutical Research. 2017; 6(10): 567-588.
21.    Xinsheng et al. Characterization of cubosomes as a targeted and sustained delivery system for Capsaicin. Drug Design Development and Therapy. 2015; 9: 4209-4218.
22.    Hadel AE, Areej HA. Nanostructured liquid crystalline formulation as a remarkable new drug delivery system of anti- epileptic drugs for treating children patients. Saudi Pharmaceutical Journal. 2018; 26: 790-800.
23.    Thoutreddy R, Gullapudi M, Bonepally CSR. Formulation and Evaluation of Dexamethsone loaded Cubosomes. Research Journal of Pharmacy and Technology. 2020; 13(2): 709-714.
24.    Mohamed N, Mohamed KG, Ahmed A. In Vitro and In vivo evaluation of cubosomes containing 5- fluorouracil for liver targeting. Acta Pharmaceutica Sinica B. 2015; 5(1): 79-88.
25.    Ahirrao M, Shrotriya S. In Vitro and In Vivo evaluation of cubosomal in situ nasal gel containing resveratrol for brain targeting. Drug Development and Industrial Pharmacy. 2017; 43(10): 1686-1693.
26.    Ismail H, Ravikumar, Narayanaswamy VB, Injamamul H, Mohibul H, Design and Evaluation of Transdermal Patches containing Risperidone. Asian Journal of Research in Pharmaceutical Sciences. 2016; 6 (4): 208- 222.
27.    Prashanth SW and Kshirsagar MD. Design and Characteriztion of Solid Lipid Nano Particles based Transdermal Drug Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2017; 7(2): 87-91.

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