Author(s): Taghreed S. Hussein, Mohammed R. Ahamad


DOI: 10.52711/0974-360X.2021.00919   

Address: Taghreed S. Hussein, Mohammed R. Ahamad
Department of Chemistry, College of Science, Baghdad University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021

Preparation of new S-glycosides including thiouracil derivatives as heterobase. The main step of this work is the formation of thiouracil derivatives [1-3] by the condensation reaction of ethyl cyanoacetate, aromatic aldehydes and thiourea to form target compounds [1-3], after protection of the hydroxyl groups in sugar (D-fructose, L- sorbose, and D-galactose), react with hydrobromic acid 45% in glacial acetic acid give different Bromo sugars [a-c], which coupled with prepares thiouracil derivatives [1-3] and propylthiouracil [4] in the presence of K2CO3 to afford the corresponding product S-glycoside analogs [1-4a, 1-4b, 1-4c]. deprotection of the S-glycoside analogs in acid and base medium, led to the free S-glycoside derivatives [1-4d,1-4e,1-4f]. The obtained compounds were tested for their antibacterial and antifungal actives.

Cite this article:
Taghreed S. Hussein, Mohammed R. Ahamad. Synthesis of S-glycosides analogues containing Thiouracil unite and Evaluated as antibacterial and Antifungal active. Research Journal of Pharmacy and Technology. 2021; 14(10):5274-9. doi: 10.52711/0974-360X.2021.00919

Taghreed S. Hussein, Mohammed R. Ahamad. Synthesis of S-glycosides analogues containing Thiouracil unite and Evaluated as antibacterial and Antifungal active. Research Journal of Pharmacy and Technology. 2021; 14(10):5274-9. doi: 10.52711/0974-360X.2021.00919   Available on:

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