Author(s): Abdu Ghalib ALKolaibe, Waill A. Elkhateeb, Marwa O. Elnahas, El-Manawaty M., Deng CY, Ting-Chi Wen, Ghoson M. Daba

Email(s): tingchiwen@yahoo.com , waillahmed@yahoo.com

DOI: 10.52711/0974-360X.2021.00914   

Address: Abdu Ghalib ALKolaibe1, Waill A. Elkhateeb2*, Marwa O. Elnahas2, El-Manawaty M.3, Deng CY4, Ting-Chi Wen5,6,7*, Ghoson M. Daba2
1Microbiology Department, Faculty of Science, Taiz University, Taiz, Yemen.
2Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Researches Division, National Research Centre, El Buhouth St., Dokki, 12311, Giza, Egypt.
3Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.
4Guizhou Institute of Biology, Guizhou Academy of Sciences, Guiyang, Guizhou 550009, China.
5State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China. 6The Engineering Research Center of Southwest Bio–Pharmaceutical Resources Ministry of Education, Guizhou University, Guiyang 550025, Guizhou Province, China.
7The Mushroom Rese

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
Metacordyceps neogunnii is an edible mushroom that has been previously known as Cordyceps gunnii. Recently, it has been proven that Metacordyceps neogunnii differs from similar species by having longer asci and wider ascospores and is phylogenetically distinct to related species. Few studies are available to describe bioactivities exerted by Metacordyceps neogunnii extracts which is insufficient to evaluate the potency of this mushroom. Therefore, the current work was conducted to evaluate the in vitro a-Amylase inhibitory ability, wound healing, and anti-human pancreatic cancer activities of Metacordyceps neogunnii 80% methanolic extract. M. neogunnii extract showed no effect on human cancer pancreatic cell line (Paca2). However, the same extract exhibited slight wound healing effect. On the other hand, M. neogunnii extract exhibited good a-amylase inhibitory activity that reached 69.3±0.78%, and IC50 of 32.38±4.0.


Cite this article:
Abdu Ghalib ALKolaibe, Waill A. Elkhateeb, Marwa O. Elnahas, El-Manawaty M., Deng CY, Ting-Chi Wen, Ghoson M. Daba. Wound Healing, Anti-pancreatic Cancer, and α-amylase Inhibitory Potentials of the Edible Mushroom, Metacordyceps neogunnii. Research Journal of Pharmacy and Technology. 2021; 14(10):5249-3. doi: 10.52711/0974-360X.2021.00914

Cite(Electronic):
Abdu Ghalib ALKolaibe, Waill A. Elkhateeb, Marwa O. Elnahas, El-Manawaty M., Deng CY, Ting-Chi Wen, Ghoson M. Daba. Wound Healing, Anti-pancreatic Cancer, and α-amylase Inhibitory Potentials of the Edible Mushroom, Metacordyceps neogunnii. Research Journal of Pharmacy and Technology. 2021; 14(10):5249-3. doi: 10.52711/0974-360X.2021.00914   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-32


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