Author(s): Karajgi S. R, Somashekhar M, Pooja Chincholi, Laxmi S. Deginal., Mhetre Bhouramma, Prabhavati Mirji, Kulkarni R.V

Email(s): santosh.karajgi@gmail.com

DOI: 10.52711/0974-360X.2021.00912   

Address: Karajgi S. R1*, Somashekhar M2, Pooja Chincholi1, Laxmi S. Deginal.1, Mhetre Bhouramma1, Prabhavati Mirji1, Kulkarni R.V3
1Dept. of Pharmaceutical Quality Assurance, BLDEA’s SSM College of Pharmacy and Research Center, Vijayapur 586103.
2Dept. of Pharmaceutical Chemistry, BLDEA’s SSM College of Pharmacy and Research Center, Vijayapur 586103.
3Dept. of Pharmaceutics, BLDEA’s SSM College of Pharmacy and Research Center, Vijayapur 586103.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spectrum between 240nm to 400nm in distilled water as the solvent was found to be suitable for the first derivative peak measurement of Capecitabine with a Linearity range throughout the concentrations of 40 microgram/ml to 80 microgram/ml. The method was successfully employed for the routine estimation on tablet dosage forms. The method was validated according to ICH guidelines. No interference from additives was observed.


Cite this article:
Karajgi S. R, Somashekhar M, Pooja Chincholi, Laxmi S. Deginal., Mhetre Bhouramma, Prabhavati Mirji, Kulkarni R.V. Novel Validated Method for the Estimation of Capecitabine in Pharmaceutical Dosage forms by First Order Derivative Spectrophotometry. Research Journal of Pharmacy and Technology. 2021; 14(10):5238-1. doi: 10.52711/0974-360X.2021.00912

Cite(Electronic):
Karajgi S. R, Somashekhar M, Pooja Chincholi, Laxmi S. Deginal., Mhetre Bhouramma, Prabhavati Mirji, Kulkarni R.V. Novel Validated Method for the Estimation of Capecitabine in Pharmaceutical Dosage forms by First Order Derivative Spectrophotometry. Research Journal of Pharmacy and Technology. 2021; 14(10):5238-1. doi: 10.52711/0974-360X.2021.00912   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-30


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