Author(s): Prasanta Kumar Mohapatra, Boddu Pavan Kumar, Pankaj Singh Patel, Harish Chandra Verma, Satyajit Sahoo

Email(s): mohapatra.kjr@gmail.com

DOI: 10.52711/0974-360X.2021.00894   

Address: Prasanta Kumar Mohapatra1*, Boddu Pavan Kumar2, Pankaj Singh Patel1, Harish Chandra Verma1, Satyajit Sahoo3
1Moradabad Educational Trust Group of Institutions, Faculty of Pharmacy, Moradabad - 244001, Uttar Pradesh, India.
2Lydia College of Pharmacy, Ravulapalem - 533238, Andhra Pradesh, India.
3C. U. Shah College of Pharmacy and Research, Surendranagar - 363001, Gujrat, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 10,     Year - 2021


ABSTRACT:
Mucoadhesive buccal films of rivastigmine were prepared by the solvent casting technique using HPMC K15M, sodium alginate, glycerine, and Eudragit RL100. Arranged films assessed for weight variation, thickness, % drug substance, % moisture loss, % moisture take-up, folding endurance, in-vitro medicament release, and Fourier transform Infrared spectroscopy (FTIR). The films showed a controlled release (CR) over 8 h. The preparation observed to be a worthy candidate for the development of buccal patches for therapeutic purposes. Drug-polymer compatibility considers FTIR demonstrated no contradiction between the medicament and the polymers. The optimized formulation found F7 indicated drug release 85% at the end of 8 h. Thinking about the correlation coefficient (R2) values got from the kinetic equations, the drug release from the formulations F1-F8 has discovered zero-order release mechanism. It can be concluded that oral buccal patches of rivastigmine, for treatment of Alzheimer’s and Parkinson’s disease, can be formulated. The study suggests that rivastigmine can be conveniently administered orally in the form of buccal patches, with the lesser occurrence of its side effects and improved bioavailability.


Cite this article:
Prasanta Kumar Mohapatra, Boddu Pavan Kumar, Pankaj Singh Patel, Harish Chandra Verma, Satyajit Sahoo. Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique. Research Journal of Pharmacy and Technology. 2021; 14(10):5133-0. doi: 10.52711/0974-360X.2021.00894

Cite(Electronic):
Prasanta Kumar Mohapatra, Boddu Pavan Kumar, Pankaj Singh Patel, Harish Chandra Verma, Satyajit Sahoo. Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique. Research Journal of Pharmacy and Technology. 2021; 14(10):5133-0. doi: 10.52711/0974-360X.2021.00894   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-10-12


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