Bi-layer tablet is one of the new technologies for the successful development of controlled release formulations along with various features. Bi-layer tablet is suitable for sequential release of two different drugs in combination, separate the two incompatible substances and also suitable for the sustained release tablet in which one layer will be immediate release which serves as initial dose and second layer is maintenance dose. Nowadays the use of this bi-layered tablet technology has been enlarged. Bi-layer tablet is useful for gradual release of two active ingredients in combination. Two different incompatible drugs can also be formulated into a bi-layer tablet by adding an inert intermediate layer. Bi-layer tablets serves as one of the principle option to avoid chemical incompatibilities between the API’s which is mainly achieved by physical separation, and also helps to enable the progress of different drug release profiles (immediate release with extended release). In spite of their advantages, the mechanical structures of this drug delivery system have become quite difficult, requiring complicated tablet architectures due to the use of different materials and also the complex geometric boundaries. Bi-layer tablets provide specific advantages when compared to the conventional release formulation of the same drug. A number of pharmaceutical companies are now currently developing bi-layer tablets.
Cite this article:
Sangeetha R, M Krishna Pillai, Y. Haribabu. Bi-layer Tablets: A Flexible Technology for Oral Drug Delivery– An Updated Review.Research J. Pharm. and Tech. 2021; 14(1):547-551. doi: 10.5958/0974-360X.2021.00099.8
Sangeetha R, M Krishna Pillai, Y. Haribabu. Bi-layer Tablets: A Flexible Technology for Oral Drug Delivery– An Updated Review.Research J. Pharm. and Tech. 2021; 14(1):547-551. doi: 10.5958/0974-360X.2021.00099.8 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-99
1. Gopinath C et al. An Overview on Bilayered Tablet Technology. Journal of Global Trends in Pharmaceutical Sciences. 2013; 4(2): 1077-1085.
2. Neha P. Singh et al. Bilayer Tablet: A Review. World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(11): 703-717.
3. Rayaprolu Mounica et al. A New Venture in Drug Delivery: Bi-layered Tablets Review. International Journal of Research in Pharmaceutical and Nano Sciences. 2013; 2(3): 305-316.
4. Anupam Sarma et al. Bilayer Tablet and Duredas Technology – A Review. International Journal of Pharmacy and Biological Sciences. 2013; 3(2): 554- 563.
5. Jaldhara S Patel et al. A Review on Bilayer Tablets. Journal of Drug Discovery and Therapeutics. 2013; 1(3): 40-48.
6. Divya A et al. Bilayer tablet technology: An overview. Journal of Applied Pharmaceutical Science. 2011; 1(8): 43-47.
7. Parnapalli Malathi et al. Recent Approaches in Bilayered Technology: Review. International Journal of Pharmaceutical Sciences and Research. 2012; 3(12): 4681-4688.
8. Verma Rameshwar et al. Bi-layer tablets for various drugs: A review. Scholars Academic Journal of Pharmacy. 2014; 3(3): 271-279.
9. Prasad Ghugarkar et al. Review on Bilayer Tablet Technology. World Journal of Pharmaceutical Research. 2015; 4(7): 1438-1452.
10. Dr. Dinesh Kaushik et al. Bilayer Tablet Technology: A Concise Review. European Journal of Pharmaceutical And Medical Research. 2019; 6(7): 573-582.
11. Sowmya C et al. An Overview on Bi-layer Tablets. International Journal of Pharmacy and Technology. 2012; 4(2): 2143-2156.
12. Sonali N. Jadhav et al. Bilayer tablet technology: An overview. International Journal of Chem Tech Research. 2017; 10(5): 595-603.
13. Bhosale M D et al. Bilayer Tablet- A Comprehensive Review. European Journal Of Pharmaceutical And Medical Research. 2017; 4(9): 241-251.
14. Hemanth Kumar A et al. Novel Approach Of Bilayer Tablet Technology –A Review. International Journal Of Pharmaceutical, Chemical And Biological Sciences. 2103; 3(3): 887-893.
15. Rohan D. Deshpande et al. Bi-Layer Tablets- An Emerging Trend: A Review. International Journal of Pharmaceutical Sciences and Research. 2011; 2(10): 2534-2544.
16. Mehraj Ud Din et al. An Overview on Bilayered Tablet Technology. American-Eurasian Journal of Scientific Research. 2014; 9(1): 06-15.