Nitish, S. Jeganath, Khilifa Fathelrahman Khalifa Abdelmagid
Nitish1, S. Jeganath1*, Khilifa Fathelrahman Khalifa Abdelmagid1
Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai - 600117, India.
Volume - 14,
Issue - 1,
Year - 2021
The major problem facing the investigators is targeted drug delivery to specific sites. The emergence of a new nanoparticles carriers known as nanosponges should address these problems. Nanosponge is a novel and arising innovation that provides for topical use controlled substance delivery. The implementation of nanosponges, its prep techniques, and assessment were addressed in this review paper. Nano-sponges play a crucial role in the controlled delivery of drugs. To guide drug delivery a wide range of drugs could be packed into nanosponge. All lipophilic and hydrophilic medicinal products could be loaded into nanosponges. The drug delivery system Nanosponge has appeared to be one of life modern science many successful sectors.
Cite this article:
Nitish, S. Jeganath, Khilifa Fathelrahman Khalifa Abdelmagid. A Review on Nanosponges – A Promising Novel Drug Delivery System. Research J. Pharm. and Tech. 2021; 14(1):501-505. doi: 10.5958/0974-360X.2021.00091.3
Nitish, S. Jeganath, Khilifa Fathelrahman Khalifa Abdelmagid. A Review on Nanosponges – A Promising Novel Drug Delivery System. Research J. Pharm. and Tech. 2021; 14(1):501-505. doi: 10.5958/0974-360X.2021.00091.3 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-91
1. Yadav GV, Panchory HP. Nanosponges–a boon to the targeted drug delivery system. J Drug Delivery Ther 2013; 3:151-5.
2. Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR. Recent advances in nanosponges as drug delivery system. Int J Pharm Sci Nanotechnol 2013; 6:1934-44
3. A. T. Singh, M. Jaggi, D. Khattar, A. Awasthi, S. K. Mishra, S. Tyagi, A. C. Burman, A novel nanopolymer based tumor targeted delivery system for paclitaxel, J Clin Oncol 2008; 26: (May 20 suppl; Abstr 11095).
4. Saima Amin, Saeid Rajabnezhad and Kanchan Kohli, Scientific Research and Essay ,2009, Vol. 3 (11), 1175-1183.
5. Bruno Sarmento, Susana Martins, Domingos Ferreira and Eliana B Souto, Oral insulin delivery by means of solid lipid nanoparticles, Int J Nanomedicine. 2007 December; 2(4): 743–749.
6. Patricia Vsan Arnum: Nanosponges, a controlled – release Nanoparticle system, shows promise in targeted drug delivery. Pharmatech.com. 35(5): 2011; 56-60.
7. Trotta F, Tumiatti V, Cavalli R, Rogero C, Mognetti B, Berta G: Cyclodextrin-based Nanosponges as a vehicle for Antitumoral drugs. WO 2009/003656 A1; 2009.
8. Liang L, De-Pei L, Chih-Chuan L: Optimizing the delivery systems of chimeric RNA. DNA oligonucleotides beyond general oligonucleotide transfer. Eur. J. Biochem 2012; 269: 5753–5758.
9. Jenny A., Merima P., Alberto F., Francesco T: Role of ß- Cyclodextrin Nanosponges in polypropylene photooxidation Carbohydrate Polymers. 2011, 86:127– 135.
10. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R: Ultrasound-assisted synthesis of Cyclodextrin-based Nanosponges. EP 1 786 841 B1; 2013.
11. Lala R, Thorat A, Gargote C: Current trends in ß- cyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526.
12. Patel G and Patel JK: Use of a Microsponge in Drug Delivery Systems. Pharmaceutical Processing. 2008; 158.
13. Khopade AJ, Jain S and Jain NK: “The Microsponge”. Eastern Pharmacist. 2012; 49-53.
14. Nimisha Jain, V Kusum Devi, Raman Dang, Uday Bhosale: Micro Sponges: A Novel Drug Delivery System. Vol 15, Issue 81, March-April, 2013.
15. Ajay Vishwakarma et al: Nanosponges: A Benefication for Novel Drug Delivery /Int. J. Pharm Tech Res.2014, 6(1), pp 11-20.
16. Sharma R, Roderick B and Pathak K: Evaluation and kinetics and mechanism of drug release from Econazole Nitrate Nanosponges loaded carbopol hydrogel. Indian J of Pharm Edu and Research (2011) 45:25-31
17. Eki S., Lei T., Jingquan L., Zhongfan J., Cyrille B., and Thomas P. D: Biodegradable Star Polymers Functionalized With ß-Cyclodextrin Inclusion Complexes, Biomacromolecule. 2013, 10(9):2699 2707.
18. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C: Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization stability and cytotoxicity. Eur J Pharm Biopharm.74: 2013; 193-201
19. Amber V, Shailendra S, Swarnalatha S: Cyclodextrin based novel drug delivery systems. J pharmaceut sci, 2012; 62:23-42.
20. Rajeswari C, Alka A, Javed A, Khar R K: Cyclodextrins in drug delivery: an update review. AAPS Pharm Sci Tech, 2013; 6(2): E329-E357.
21. Subramanian S., Singireddy A., Krishnamoorthy K., Rajappan M: Nanosponges: A Novel Class of Drug Delivery System – Review, J Pharm Pharmaceutical Sci. (www.cspsCanada.org) 15(1) 103 - 111, 2012, visited on 15/10/2011.
22. Ramnik S, Nitin B, Jyotsana M, Horemat SN: Characterization of Cyclodextrin Inclusion complexes –A Review. J Pharm Sci Tech, 2010; 2(3):171-183.
23. Wolfgang S: Sample preparation in Light Scattering from and Nanoparticle Dispersions. Springer Berlin Heidelberg GmbH & Co. Int J Pharm 2013; 344(1-2): 33-43.
24. Aithal KS, Udupa N and Srinivasan KK. Physicochemical properties of drug cyclodextrin complexes. Indian drugs (2008) 32:293-305
25. Duchene D, Vaution C, Glomot F: Cyclodextrin, Their Value in pharmaceutical Technology. Drug Dev Ind Pharm, 2012; 12(11-13): 2193-2215.
26. Tayade PT, Vavia PP: Inclusion complexes of Ketoprofen with ß- cyclodextrins: Oral pharmacokinetics of Ketoprofen in human. Indian J Pharm Sci, 2012; 68(2):164-170.
27. Renuka S, Kamla P: Polymeric Nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation Pharm Dev Technol. 2011; 16(4):367-376.
28. Leslie Z. Benet: BCS and BDDCS. Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability. Department of biopharmaceutical sciences, University of California, San Francisco, USA, 2007.
29. Rosalba M, Roberta C, Roberto F, Chiara D, Piergiorgio P, Leigh E, Li S, Roberto P: Antitumor activity of nanosponge-encapsulate Camptotechin in human prostate tumors. Cancer Res, 2011; 71:4431
30. Torne SJ, Ansari KA, Vavia PR, Trotta F, Cavalli R: Enhanced oral Paclitaxel bioavailability after administration of Paclitaxel loaded nanosponges. Drug Delivery, 2010; 17(6):419–425.
31. Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R: Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7cell line culture. Curr Drug Deliv, 2011; 8(2):194-202.
32. William K, Benjamin S, Eva H: Synthesis and Characterization of Nanosponges for Drug Delivery and Cancer Treatment. www.Vanderbilt.edu accessed on 20.12.2011.
33. Khalid AA, Pradeep RV, Francesco T, Roberta C: Cyclodextrin-based nanosponges for delivery of Resveratrol: In Vitro characterization, stability, cytotoxicity and permeation Study. AAPS Pharm Sci Tech, 2011; 12(1): 279-286.
34. Melanie F, Mura P, Adamo M, Maestrelli F, Gratteri P and Bonaccini C. (2003). New docking CFF91 parameters specific for cyclodextrin inclusion co4mplexes. Chemical Physics Letters; 370(1-2): 280-292.
35. Khalid AA, Pradeep RV, Francesco T, Roberta C: Cyclodextrin-based nanosponges for delivery of Resveratrol: In Vitro characterization, stability, cytotoxicity and permeation Study. AAPS Pharm Sci Tech, 2011; 12(1): 279-286.
36. Ansari K., Torne S., Vavia P.R., Trotta F., Cavalli R.: Cyclodextrin - Based Nanosponges for Delivery of Resveratrol: In Vitro Characterization, Stability, Cytotoxicity and Permeation Study. AAPS Pharm Sci Tech, Vol. 12, No. 1, March 2011.