Author(s): J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan

Email(s): dev.srvana@gmail.com

DOI: 10.5958/0974-360X.2021.00009.3   

Address: J. Padmavathy1, T. Venkatachalam2, I. Sarath Chandiran3, S. G. Raman3, R. Rajkumar4, D. Saravanan5*
1School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu - 600117.
2Annai JKK Sampoorn Ammal College of Pharmacy, Komarapalayam, Namakkal, District, Tamil Nadu - 638183.
3School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Puducherry - 607402.
4Kamalakshi Pandurangan College of Pharmacy, Ayyampalayam, Thiruvannamalai, Tamil Nadu, India-606603.
5Jaya College of Paramedical Sciences, College of Pharmacy, CTH Road, Thiruninravur, Chennai, Tamil Nadu, India-602024.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021


ABSTRACT:
The present study was carried out to find out the in-vivo anti-inflammatory and anti-diabetic activities of ethanol extract (200 and 400mg/kg) of leaves of Actinodaphne madraspatana (A. madraspatana) on Swiss Albino rats. The anti-inflammatory activity was investigated in carrageenan induced rat paw edema model which was compared with standard drug indomethacin at a dose level of 10mg/kg and the parameter measured being the paw volume by mercury displacements at 0, 15, 30, 60, and 120 minutes. The edema was induced in rats by administration of 1 % w/v solution of carrageenan in normal saline solution (1%w/v). The anti-diabetic activity was investigated in streptozotocin induced diabetic rat, which was compared with standard drug glibenclamide at a dose level of 4 mg/kg and the parameter measured being the blood glucose level on 0, 7, 14, 21 days. Diabetes was induced in rats by administration of streptozotocin (60mg/kg) in ice cold citrate buffer (pH 4.3). Results of pharmacological activities revealed that the ethanol extract of the plant leaves showed the significant (p?0.001) anti-inflammatory and anti-diabetic activities in a dose of 200mg/kg and 400 mg/kg body weight. The ethanol extract of leaves of A.madraspatana possess the anti-inflammatory and anti-diabetic activities.


Cite this article:
J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan. Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves. Research J. Pharm. and Tech. 2021; 14(1):47-51. doi: 10.5958/0974-360X.2021.00009.3

Cite(Electronic):
J. Padmavathy, T. Venkatachalam, I. Sarath Chandiran, S. G. Raman, R. Rajkumar, D. Saravanan. Evaluation of Anti-inflammatory and Anti-diabetic activities of Actinodaphne madraspatana bedd leaves. Research J. Pharm. and Tech. 2021; 14(1):47-51. doi: 10.5958/0974-360X.2021.00009.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-9


REFERENCES:
1.    Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environmental Health Perspective, 2001;109:69-75.
2.    Prajapati D, Patel N, Mruthunjaya K, Savadi R. Antioxidant activity of Actinodaphne hookerimeissn leaves. Journal of Scientific Research. 2009; 1:606-14.
3.    Rasool Hassan BA. Medicinal plants (Importance and Uses). Pharmaceutica Analytica Acta. 2012; 3:10.    
4.    Gupta AK. Reviews on Indian medicinal plants, New Delhi: Indian council of medicinal research.2004.
5.    Adinarayana D, Gunasekar D. A new flavone from A.madraspatana. Indian Journal of Chemistry. 1979; 18B:552.
6.    Pullaiah T. Medicinal plants in Andhra Pradesh, New Delhi: Regency Publications. 2002.
7.    Ecobichon DJ. The basis of toxicology testing, 2nd ed. New York: CRC press.1997.
8.    Dev Nath Singh Gautam. Physicochemical and Acute Toxicity Study of Gunja (Abrus precatorius) Pericarp. Research Journal of Pharmacy and Technology. 2018; 11:1935-939.
9.    Ronald Darwin C, Vijaya C, Sujith K, Sadhavi M, Haneesha Pothuri. Acute and sub-acute toxicological evaluation of aqueous and ethanol fractions of Annona squamosa root a traditional medicinal herb. Research Journal of Pharmacy and Technology. 2011; 4: 1475-479.
10.    Maheswari C, Venkatnarayanan R, Babu P, Benito Jhonson D, Siraj Kattuparuthi, Krishna G. Anti-Inflammatory activity of Methanol Extract of the Leaves of Orthosiphon stamineus. Research Journal of Pharmacy and Technology. 2012; 5: 1585-587.
11.    Benni JM, Jayanthi MK, Suresha RN. Evaluation of anti-inflammatory activity of Aeglemarmelos (Bilwa) root. Indian Journal of Pharmacology, 2011; 43:393-97.
12.    Rupesh Pandey, Ravindra Pandey, Shukla SS. Anti-inflammatory potential of ethanol extract of Rubus ulmifolius (Schott). Research Journal of Pharmacy and Technology. 2013; 6: 300-03.
13.    Manpreet Kaur. Evaluation of Anti-inflammatory activity of Ethanol Extract of Bark of Aspidosperma quebraco-blanco. Research Journal of Pharmacy and Technology. 2013; 6: 575-76.
14.    Pradeep Kumar CH, Lokesh T, Gobinath M, Kumar B, Saravanan. D. Anti-diabetic and anti-hyperlipidemic activities of glucomannan isolated from Araucaria cunninghamii seeds. Journal of Chemical and Pharmaceutical Sciences. 2013;6: 204-09.
15.    Okokon JE, Antia BS, Udobang JA. Anti-diabetic activities of ethanolic extract andfraction of Anthocleista djalonensis. Asian Pacific Journal of Tropical Biomedicine. 2012; 2:461-64.
16.    Vinay S, Karimulla SK, Saravanan D. GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of Jasminum cuspidatum leaves. Bangladesh Journal of Pharmacology. 2014; 9:610-16.
17.    Tripathi J, Kumari R, Ashwlayan VD, Bansal P, Singh R. Anti-diabetic activity Diplocyclos palmatus Linn. in streptozotocin-induced Diabetic mice. Indian Journal of Pharmaceutical Education and Research. 2012;46: 352-59.
18.    18. Hassan HS, Sule MI, Musa AM, Abubakar MS, Hassan AS. Anti-inflammatory activity of crude Saponin extracts from five Nigerian medicinal plants. African Journal of Traditional, Complementary and Alternative Medicine. 2012; 9:250-55.
19.    Sharififar F, Khazaeli P, Alli N, Talebian E, Zarehshahi R, Amiri S. Study of antinocieptive and anti-inflammatory activities of certain Iranian medicinal plants. Journal of Intercultural Ethnopharmacology. 2012; 1:19-24.
20.    Sabitha V, Ramachandran S, Naveen KR, Panneer selvam K. Anti-diabetic and anti-hyperlipidemic potential of Abelmoschus esculentus (L.) Moench in streptozotocin induced diabetic rats. Journal of Pharmacy and Bioallied Sciences. 2011; 3:397-402.
21.    Gutierrez RP, Gomez YY, Guzman MD. Attenuation of nonenzymatic glycation, hyperglycemia, and hyperlipidemia in sterptozotocin-induced diabetic rats by chloroform leaf extract of Azadirachta indica. Pharmacognosy Magazine. 2011; 7:254-59.
22.    Orhan N, Aslan M, Hosbas S, Orhan DD. Antidiabetic effect and Antioxidant potential of Rosa canina Fruits. Pharmacognosy Magazine. 2009; 5:309-15.
23.    Belhekar SN, Chaudhari PD, Saryawanshi JS, Mali KK, Pandhare RB. Anti-diabeticand anti-hyperlipidemic effects of Thespesia populnea fruit pulp extracts on alloxan- induced diabetic rats. Indian Journal of Pharmaceutical Sciences. 2013; 75:217-21.
24.    Mayank Panchal, Biren Shah, Krishna Murti, Megha Shah. Phytochemical investigation and antidiabetic activity studies of Moringa oliefera roots. Research Journal of Pharmacology and Pharmacodynamics. 2011; 3: 268-77.
25.    Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika. Evaluation of Antidiabetic Activity of Rumex vesicarius in Streptozotocin Induced Diabetic Albino Rats. Research Journal of Pharmacology and Pharmacodynamics.2016; 8: 123-26.
26.    Rajiv Gandhi G, Sasikumar P. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine. 2012; 2:281-86.
27.    Islam S, Ahmed MR, Mahamud RA, Rahman S, Azam FMS, Jahan R, Rahmatullah M. Callus extract of Ipomoea mauritiana show analgesic and antihyperglycemic activity in Swiss albino mice. Journal of Applied Pharmaceutical Sciences. 2015; 5: 044-47.
28.    Ramana Murty Kadali SLDV, Magala Charan Das, Gupatha Bayya MHRK, Vijay Kumar M. Preliminary Phytochemical Screening and Evaluation of effect of aqueous and Ethanolic leaf extracts of Chloroxylon swietenia on blood glucose in Streptozotocin Induced Diabetic rats. Research Journal of Pharmacy and Technology. 2019; 12:5495-500.
29.    Deepak Kumar Jha, Raju Koneri, Suman Samaddar. Antidiabetic Activity of Phytosaponin in STZ-Induced Type I Diabetes in Rats. Research Journal of Pharmacy and Technology. 2019; 12:3919-926.
30.    Arpita Karandikar, G. Sriram Prasath, S. Subramanian. Evaluation of Antidiabetic and Antioxidant Activity of Praecitrullus fistulosus Fruits in STZ Induced Diabetic Rats. Research Journal of Pharmacy and Technology. 2014; 7: 196-03.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available