Author(s): Amitha Ramesh, Sudhir Rama Varma, Srinivas Ramamurthy, Maher al Shayeb, Moyad Shahwan, Abed M. Atia Elkaseh, Al Moutassem Billah Khair, Adil Mageet, Madeeha Arif, Biju Thomas, Pavithra Jaganathan, Suchetha Shetty, Sharmila K.P

Email(s): s.varma@ajman.ac.ae

DOI: 10.5958/0974-360X.2021.00072.X   

Address: Amitha Ramesh1, Sudhir Rama Varma2,8, Srinivas Ramamurthy3, Maher al Shayeb2,8, Moyad Shahwan4,8, Abed M. Atia Elkaseh2,8, Al Moutassem Billah Khair5,8, Adil Mageet2,8, Madeeha Arif6, Biju Thomas1, Pavithra Jaganathan1, Suchetha Shetty7, Sharmila K.P7
1Department of Periodontics, A.B. Shetty Memorial Institute of Dental Sciences, Mangaluru, Karnataka, India.
2Department of Clinical sciences, College of Dentistry, Ajman University, Ajman, U.A.E.
3Department of Pharmaceutical Sciences, College of Pharmacy, University of Science and Technology of Fujairah, Fujairah, U.A.E.
4 Department of Clinical Sciences College of Pharmacy and Health Sciences, Ajman University, Ajman, U.A.E.
5 Department of Basic Sciences, College of Dentistry, Ajman University of, Ajman, U.A.E.
6 College of Dentistry, University of Science and technology of Fujairah, U.A.E.
7 Central Research Laboratory, Department of Biochemistry, K.S. Hegde Medical academy, Deralakattae, Mangaluru, Karnataka, India.

Published In:   Volume - 14,      Issue - 1,     Year - 2021


ABSTRACT:
Objective: The role of TLRs as principal signaling receptors in recognizing endotoxins on gram positive and negative bacteria is facilitated by TLRs and further enhances its role as a potential biomarker in assessing periodontal disease. The study aimed at evaluating the expression of sTLR2 and sTLR4 among healthy, periodontal and diabetic patients and further if there a comparable expression among the TLRs among genders. Material and Methods: Patients were selected according to pocket depth, Clinical attachment loss and radiographic bone loss. Unstimulated whole saliva was collected. sTLR2 and sTLR4 quantification was estimated by ELISA. Comparison of sTLRs between the study groups were performed using ANOVA followed by Tukey post Hoc test. Independent sample t test was used to compare between the genders. (p=0.05) Result: Expression of sTLR2 was higher among periodontitis patients compared to diabetic patients, this was also evident with relation to genders. sTLR4 showed significant expression among the three groups and also among the genders. Conclusion: The expression of sTLR2 was higher among periodontitis patients compared to diabetic patients. More studies need to be carried out to evaluate TLRs values among genders.


Cite this article:
Amitha Ramesh, Sudhir Rama Varma, Srinivas Ramamurthy, Maher al Shayeb, Moyad Shahwan, Abed M. Atia Elkaseh, Al Moutassem Billah Khair, Adil Mageet, Madeeha Arif, Biju Thomas, Pavithra Jaganathan, Suchetha Shetty, Sharmila K.P. Role of sToll-like receptors 2 and 4 in stage 2 periodontitis patients with and without type 2 diabetes: A Randomized clinical control trial. Research J. Pharm. and Tech. 2021; 14(1):397-404. doi: 10.5958/0974-360X.2021.00072.X

Cite(Electronic):
Amitha Ramesh, Sudhir Rama Varma, Srinivas Ramamurthy, Maher al Shayeb, Moyad Shahwan, Abed M. Atia Elkaseh, Al Moutassem Billah Khair, Adil Mageet, Madeeha Arif, Biju Thomas, Pavithra Jaganathan, Suchetha Shetty, Sharmila K.P. Role of sToll-like receptors 2 and 4 in stage 2 periodontitis patients with and without type 2 diabetes: A Randomized clinical control trial. Research J. Pharm. and Tech. 2021; 14(1):397-404. doi: 10.5958/0974-360X.2021.00072.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-72


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