Author(s): Alfred Maroyi

Email(s): amaroyi@ufh.ac.za

DOI: 10.5958/0974-360X.2021.00046.9   

Address: Alfred Maroyi
Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2021


ABSTRACT:
Lantana rugosa is a small shrub widely used as traditional medicine in southern Africa. The current investigation critically reviewed the pharmacological properties and medicinal uses of L. rugosa. Results of this study are based on literature search on pharmacological properties and medicinal uses of L. rugosa using several internet sources such as Scopus, Elsevier, SciFinder, Google Scholar, Pubmed, Science Direct and Web of Science. Other sources of information included pre-electronic sources such as journal articles, theses, book chapters, books and other scientific publications obtained from the University library. This study revealed that leaf, root, stem and fruit infusions and decoctions of L. rugosa are used as ethnoveterinary medicine and traditional medicine for sprains, sore throat, cuts, stomach problems, fever, sores, rheumatism, abdominal pains, sore eyes and respiratory problems. Ethnopharmacological research identified alkaloids and essential oils from the leaves of L. rugosa. The leaf and stem extracts of L. rugosa exhibited anthelmintic, antibacterial, antifungal and cytotoxic activities. Lantana rugosa should be subjected to further pharmacological, phytochemical and toxicological studies aimed at correlating its medicinal applications with ethnopharmacological properties.


Cite this article:
Alfred Maroyi. Pharmacological properties and Medicinal applications of Lantana rugosa Thunb. (Family Verbenaceae). Research J. Pharm. and Tech. 2021; 14(1):259-264. doi: 10.5958/0974-360X.2021.00046.9

Cite(Electronic):
Alfred Maroyi. Pharmacological properties and Medicinal applications of Lantana rugosa Thunb. (Family Verbenaceae). Research J. Pharm. and Tech. 2021; 14(1):259-264. doi: 10.5958/0974-360X.2021.00046.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-46


REFERENCES:
1.    Schimdt E, Lötter M and McMleland W. Trees and shrubs of Mpumalanga and Kruger National Park. Jacana Media, Johannesburg, South Africa; 2017.
2.    Papo L. Lantana rugosa, Pretoria National Botanical Garden, 2019. Available from: http://pza.sanbi.org/lantana-rugosa, accessed on 12 December 2019.
3.    Glen HF. Sappi: What’s in a name? The meanings of the botanical names of trees. Jacana, Johannesburg, South Africa; 2004.
4.    Germishuizen G and Meyer NL. Plants of Southern Africa: An annotated checklist. Strelitzia 14. National Botanical Institute, Pretoria, South Africa; 2003.
5.    Fernandes R. Verbenaceae. In Pope GV and Martins ES (Editors), Flora Zambesiaca volume 8, part 7, Royal Botanic Gardens, Kew, Richmond; UK; 2005, pp. 6-61.
6.    Figueiredo E and Smith GF. Plants of Angola. Strelitzia 22, South African National Biodiversity Institute, Pretoria, South Africa; 2008.
7.    Hyde MA, et al. Flora of Zimbabwe: Species information: Lantana rugosa, 2020. Available from: https://www.zimbabweflora.co.zw/ speciesdata/species.php?species_id=148650, accessed on 10 December 2019.
8.    Atkins S. Verbenaceae. In Kubitzki K (Editor), The Families and genera of flowering plants, volume VII, Lamiales. Springer, Berlin, Germany; 2004, pp. 449-468
9.    Drummond RB. A list of trees, shrubs and woody climbers indigenous or naturalised in Rhodesia. Kirkia. 1975; 10(2): 229–285
10.    Setshogo MP. Preliminary checklist of the plants of Botswana. South African National Biodiversity Institute, Pretoria, South Africa; 2005.
11.    Ouamba J-M, et al. Volatile constituents of the essential oil leaf of Lantana salvifolia Jacq. (Verbenaceae). Flavour and Fragrance Journal. 2006; 21: 158-161.
12.    Bandeira S, Bolnick D and Barbosa F. Wild flowers of southern Mozambique, Universidade Eduardo Mondlane, Maputo, Mozambique; 2007.
13.    Hyde MA, et al. Flora of Caprivi: Individual record no: 80059: Lantana rugosa, 2020. Available from: https:// www.capriviflora.com/speciesdata/species-record.php?record_id=80059, accessed on 10 December 2019.
14.    Watt JM and Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. E & S Livingstone, London, UK; 1962.
15.    Diederichs N, Nichols G and Van Niekerk M. Green landscaping guideline. eThekwini Municipality, Durban, South Africa; 2009.
16.    Jacot Guillarmod A. Flora of Lesotho. Cramer, Lehre, Germany; 1971.
17.    Liengme CA. Plants used by the Tsonga people of Gazankulu. Bothalia. 1981; 13: 501-518.
18.    Fox FW and Norwood Young ME. Food from the Veld: Edible wild plants of southern Africa. Delta Books, Johannesburg, South Africa; 1982.
19.    Mabogo DEN. The ethnobotany of the Vhavenda. MSc Dissertation. University of Pretoria, Pretoria, South Africa;1990.
20.    Peters CR, O'Brien EM and Drummond RB. Edible wild plants of sub-Saharan Africa. Royal Botanic Gardens, Kew, Richmond, UK; 1992.
21.    Shackleton SE, et al. Use and trading of wild edible herbs in the central lowveld savanna region, South Africa. Economic Botany.1998; 52(3): 251-259.
22.    Shava S. The use of indigenous plants as food by a rural community in the Eastern Cape: Tuku 'A' Village, Peddie. Southern African Journal of Environmental Education. 1999; 19: 85-97.
23.    Leffers A. Gemsbok bean and kalahari truffle: Traditional plant use by the Jul’hoansi in northern-eastern Namibia. Gamsberg Macmillan, Windhoek, Namibia; 2003.
24.    Long C. Swaziland’s flora: Siswati names and uses. Mbambane, Swaziland: Swaziland National Trust Commission, 2005. Available from: http://www .sntc.org.sz/index.asp, accessed on 29 December 2019.
25.    Moteetee A and Van Wyk B-E. Sesotho names for exotic and indigenous edible plants in southern Africa. Bothalia. 2006; 36: 25–32.
26.    Moffett RO. Sesotho plant and animal names and plants used by the Basotho. Sun Press, Stellenbosch, South Africa; 2010.
27.    Dlamini CS and Geldenhuys CJ. A resource survey for medicinal and edible plant species in the four ecological zones of rural Swaziland. Journal of Geography and Regional Planning. 2011; 4(9): 557-555.
28.    Mbhenyane XG, et al. The consumption of indigenous fruits and vegetables and health risk in rural subjects of Limpopo Province, South Africa. Indilinga African Journal of Indigenous Knowledge Systems. 2013; 12(1):160-168.
29.    Constant NL and Tshisikhawe MP. Hierarchies of knowledge: ethnobotanical knowledge, practices and beliefs of the Vhavenda in South Africa for biodiversity conservation. Journal of Ethnobiology and Ethnomedicine. 2018; 14:56.
30.    Magwede K, Van Wyk B-E and Van Wyk AE. An inventory of Vhavenḓa useful plants. South African Journal of Botany.2019; 122: 57–89.
31.    Mogale MMP, Raimondo DC and Van Wyk B-E. The ethnobotany of central Sekhukhuneland, South Africa. South African Journal of Botany.2019; 122: 90–119.
32.    Moteetee A, Moffett RO and Seleteng-Kose L. A review of the ethnobotany of the Basotho of Lesotho and the Free State province of South Africa (South Sotho). South African Journal of Botany. 2019; 122: 21–56.
33.    Welcome AK and Van Wyk B-E. An inventory and analysis of the food plants of southern Africa. South African Journal of Botany. 2019; 122: 136–179.
34.    Hutchings A, et al. Zulu medicinal plants: An inventory. University of Natal Press, Pietermaritzburg, South Africa; 1996.
35.    Kunene N, Wilson RAC and Myeni NP. The use of trees, shrubs and herbs in livestock production by communal farmers in northern KwaZulu-Natal, South Africa. African Journal of Range and Forage Science. 2003; 20(3): 271-274.
36.    ArnoldH-J and Gulumian M. Pharmacopoeia of traditional medicine inVenda. Journal of Ethnopharmacology. 1984; 12: 35-74.
37.    Ramarumo LJ, Maroyi A and Tshisikhawe MP. Warburgia salutaris (G.Bertol.) Chiov.: An endangered therapeutic plant used by the Vhavenḓa ethnic group in the Soutpansberg, Vhembe Biosphere Reserve, Limpopo province, South Africa. Research Journal of Pharmacy and Technology 2019; 12: 5893-5898.
38.    Banu UK, Vadivu R and Suresh AJ. Pharmacognostical standardization of roots of Premna Serratifolia Linn. Research Journal of Pharmacy and Technology2009; 2(1): 180-185.
39.    Beck NR and Samal P. Traditional medicinal plants used by the tribes and rural people of Bilaspur district, Chhattisgarh (India). Research Journal of Pharmacy and Technology.2012; 5(10): 1281-1282.
40.    Rajendran R and Basha NS. Cardioprotective effect of ethanol extract of stem-bark and stem-wood of Premna serratifolia Lin., (Verbenaceae). Research Journal of Pharmacy and Technology. 2008; 1(4): 487-491.
41.    Jain T, et al. Regulatory status of traditional medicines in different countries: An overview. Research Journal of Pharmacy and Technology. 2011; 4(7): 1007-1015.
42.    Osemene KP, Ilori MO and Elujoba AA. Generation and acceptability of herbal medicines research and development outputs in Nigeria. Research Journal of Pharmacy and Technology. 2013; 6(3): 232-237.
43.    Osemene KP, Ilori MO and Elujoba AA. Assessing the commercialization of herbal medicines research and development outputs in Nigeria. Research Journal of Pharmacy and Technology. 2013; 6(6): 622-631.
44.    Ebrahimi Y, et al. Natural antioxidants and medicinal plants effective on hyperlipidemia. Research Journal of Pharmacy and Technology. 2019; 12(3): 1457-1462.
45.    Dave PH, Vishnupriya V and Gayathri R. Herbal remedies for anxiety and depression: A review. Research Journal of Pharmacy and Technology. 2016; 9(8):1253-1256.
46.    Anbari K, et al. Concise overview: A review on natural antioxidants and important herbal plants on gastrointestinal System. Research Journal of Pharmacy and Technology. 2019; 12(2):841-847.
47.    Roberts M. Indigenous healing plants. Southern Book Publishers, Halfway House, Johannesburg, South Africa; 1990.
48.    Von Koenen E. Medicinal, poisonous, and edible plants in Namibia. Klaus Hess Publishers, Windhoek, Namibia; 2001.
49.    McGaw LJ and Eloff JN. Ethnoveterinary use of southern African plants and scientific evaluation of their medicinal properties. Journal of Ethnopharmacology.2008; 119(3): 686–699.
50.    McGaw LJ, et al. The potential of South African plants against Mycobacterium infections. Journal of Ethonopharmacology. 2008; 119(3):482-500.
51.    Suliman A. The antimicrobial activity and chemical profile of traditional medicinal plants indigenous to southern Africa used to treat respiratory tract infections. MSc Dissertation. University of the Witwatersrand, Johannesburg, South Africa; 2010.
52.    Mabona U. Antimicrobial activity of southern African medicinal plants with dermatological relevance. MSc Dissertation, University of the Witwatersrand, Johannesburg, South Africa; 2013.
53.    Mabona U and Van Vuuren SF. Southern African medicinal plants used to treat skin diseases. South African Journal of Botany. 2013; 87: 175–193.
54.    Mabona U, et al. Antimicrobial activity of southern African medicinal plants with dermatological relevance: From an ethnobotanical screening approach, to combination studies and the isolation of a bioactive compound. Journal of Ethnopharmacology. 2013; 148: 45–55
55.    Mahwasane ST, Middleton L and Boaduo N. An ethnobotanical survey of indigenous knowledge on medicinal plants used by the traditional healers of the Lwamondo area, Limpopo province, South Africa. South African Journal of Botany.2013; 88: 69–75.
56.    Sewani-Rusike CR and Mammen M. Medicinal plants used as home remedies: a family survey by first year medical students. African Journal Traditional Complementary and Alternative Medicine. 2014; 11(5):67-72.
57.    Semenya SS and Maroyi A. Plants used by Bapedi traditional healers to treat asthma and related symptoms in Limpopo province, South Africa. Evidence-Based Complementary and Alternative Medicine. 2018; Article ID 2183705.
58.    Semenya SS and Maroyi A. Ethnobotanical study of plants used medicinally by Bapedi traditional healers to treat sinusitis and related symptoms in the Limpopo province, South Africa. Journal of Applied Botany and Food Quality.2018; 91: 287–295.
59.    Semenya SS and Maroyi A. Data on medicinal plants used to treat respiratory infections and related symptoms in South Africa. Data in Brief. 2018; 21: 419-423.
60.    Semenya SS and Maroyi A. Medicinal applications of plants by Bapedi traditional healers for sore throat and related symptoms in the Limpopo province, South Africa. Medicinal Plants: International Journal of Phytomedicines and Related Industries.2018; 10(4): 261-280.
61.    Semenya SS and Maroyi A. Ethnobotanical survey of plants used by Bapedi traditional healers to treat tuberculosis and its opportunistic infections in the Limpopo province, South Africa. South African Journal of Botany.2019; 122: 401–421.
62.    Semenya SS and Maroyi A. Source, harvesting, conservation status, threats and management of indigenous plant used for respiratory infections and related symptoms in the Limpopo Province, South Africa. Biodiversitas. 2019; 20: 790-811.
63.    Semenya SS and Maroyi A. Source of plants, used by Bapedi traditional healers for respiratory infections and related symptoms in the Limpopo province, South Africa. Journal of Biological Sciences. 2019; 19(2): 101-121.
64.    Makhafola MA, et al. Cytotoxic and antibacterial activity of selected medicinal plants used in South African traditional medicine. Asian Journal of Chemistry. 2019; 31: 2623-2627.
65.    Mashile SP, Tshisikhawe MP and Masevhe NA. Medicinal plants used in the treatment of maternal health-related problems by the Mapulana of Ehlanzeni District, Mpumalanga province, South Africa. Journal of Applied Pharmaceutical Science. 2019; 9(12): 21–29.
66.    Mhlongo LS and Van Wyk B-E. Zulu medicinal ethnobotany: new records from the Amandawe area of KwaZulu-Natal, South Africa. South African Journal of Botany. 2019; 122: 266–290.
67.    Khunoana ET and McGaw LJ. Ethnoveterinary medicinal plants used in South Africa. In McGaw LJ and Abdalla MA (Eds.), Ethnoveterinary Medicine: Present and Future Concepts. Springer Nature, Cham, 2020, pp. 211-250.
68.    Ghisalberti EL. Lantana camara L. (Verbenaceae). Fitoterapia. 2000; 71: 467-486.
69.    Nagão T, et al. Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biological and Pharmaceutical Bulletin. 2002; 25: 875- 879.
70.    Hernández T, et al. Ethnobotany and antibacterial activity of some plants used in traditional medicine of Zapotitlán de las Salinas, Puebla (México). Journal of Ethnopharmacology. 2003; 88: 181-188.
71.    Okunade AL and Lewis WH. Oleanene constituents of Lantana cujabensis. Fitoterapia. 2004; 75: 327-331.
72.    Silva GN, et al. Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia. Journal of Ethnopharmacology. 2005; 100: 254-259.
73.    Jiménez-Arellanes A, et al. Antimycobacterial triterpenoids from Lantana hispida (Verbenaceae). Journal of Ethnopharmacology. 2007; 111: 202-205.
74.    Innocent E, et al. Mosquito larvicidal constituents from Lantana viburnoides sp viburnoides var.kisi (A. rich) Verdc (Verbenaceae). Journal of Vector Borne Diseases. 2008; 45: 240-244.
75.    Julião LS, et al. Phenylethanoid glycosides from Lantana fucata with in vitro anti-inflammatory activity. Journal of Natural Products. 2009; 72: 1424-1428.
76.    Sena Filho JG, et al. A chemical marker proposal for the lantana genus: composition of the essential oils from the leaves of Lantana radula and L. canescens. Natural Product Communications. 2010; 5: 635-640.
77.    Sousa EO and Costa JGM. Genus Lantana: chemical aspects and biological activities. Revista Brasileira de Farmacognosia Brazilian Journal of Pharmacognosy. 2012; 22(5): 1155-1180.
78.    Papo LA. The Ethnobotanical, Antimicrobial and Phytochemical Screening of Selected Medicinal Plants from Ga-Mashashane, Limpopo, South Africa. MSc Dissertation, University of Johannesburg, Johannesburg, South Africa; 2017.
79.    McGaw LJ and Eloff JN. Screening of 16 poisonous plants for antibacterial, anthelmintic and cytotoxic activity in vitro. South African Journal of Botany. 2005; 71: 302–306.
80.    Makhubu FN, Khosa MC and McGaw LJ. Can plants with good anthelmintic activity against free-living and animal parasitic nematodes be effective against plant parasitic nematodes? Planta Medica. 2019; 85(18): 127.
81.    Makhubu FN, Khosa MC and McGaw LJ. Activity of three South African plants on phytopathogenic bacteria and fungi of tomatoes and chemical profiling of the extracts. Planta Medica. 2019; 85(18): 1508.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available