Padmini Iriventi, N. Vishal Gupta
Padmini Iriventi*, N. Vishal Gupta
Department of Pharmaceutics, JSS College of Pharmacy, Sri Shivarathreeshwara Nagara, Mysuru, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysuru – 570015, Karnataka, India.
Volume - 14,
Issue - 1,
Year - 2021
Psoriasis is the most common chronic autoimmune disease. The objective of the present study was to formulate herbal cream that consists of Azadirachta indica (Neem) extract used in treating Psoriasis. Various phytochemical identification tests were carried out using reagents. DPPH (2,2- diphenyl-1-picrylhydrazyl) free radical scavenging assay was carried out to confirm antioxidant activity. Coconut oil, Olive oil and Vitamin E oil were used in the formulation which provides different pharmaceutical activities. Phytoconstituents present in the herbal extract were identified by Liquid Chromatography-Mass Spectroscopy (LC-MS) studies. Evaluation studies were carried out for prepared cream. LC-MS studies concluded that various herbal constituents were identified and it concludes that active constituents responsible for treating psoriasis were present in the obtained extract and also possessed antioxidant activity.
Cite this article:
Padmini Iriventi, N. Vishal Gupta. Formulation and Evaluation of Herbal Cream for Treating Psoriasis. Research J. Pharm. and Tech. 2021; 14(1):167-170. doi: 10.5958/0974-360X.2021.00029.9
Padmini Iriventi, N. Vishal Gupta. Formulation and Evaluation of Herbal Cream for Treating Psoriasis. Research J. Pharm. and Tech. 2021; 14(1):167-170. doi: 10.5958/0974-360X.2021.00029.9 Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-1-29
1. Michelle AL, Anne MB, James GK: Pathogenesis and therapy of psoriasis. Nature. 2007; 445:866-872.
2. Sanaa EG, Maha F, Basma M, Fatma EZ. Betamethasone dipropionate gel for treatment of localized plaque psoriasis. International Journal of Pharmacy and Pharmaceutical Sciences. 2017; 9:173-182.
3. Susmitha S, Vidyamol KK, Ranganayaki P, Vijayaragavan R. Phytochemical Extraction and Antimicrobial Properties of Azadirachta indica (Neem). Global Journal of Pharmacology. 2015; 7:316-320.
4. Debjit B, Chiranjib, Jitender Y, Tripathi KK, Sampath Kumar KP. Herbal Remedies of Azadirachta indica and its Medicinal Application. Journal of Chemical and Pharmaceutical Research. 2010; 2:62-72.
5. Birendra KB, Ashok KP: Green synthesis of Gold nanoparticles using neem (Azadirachta indica L.) leaf extract and its biomedical applications. International Journal of Advanced Biotechnology and Research. 2014; 5:457-464.
6. Mahmoud DA, Hassanein NM, Youssef KA, Abouzeid MA: Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. Brazilian Journal of Microbiology. 2011; 42:1007-1016.
7. Patrick VQ, Márcia LG, Maria AG, Raimunda C, David FL, Carlos N, Marcos PN et al. Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant Staphylococcus aureus biofilm formation and Schistosoma mansoni worms. Journal of Ethnopharmacology. 2015; 175:287-294.
8. Sami B, Olivier P. Analysis of neem oils by LC–MS and degradation kinetics of azadirachtin-A in a controlled environment. Characterization of degradation products by HPLC–MS–MS. Analytical and Bioanalytical Chemistry. 2004; 378:753-763.
9. Garima P, Verma KK, Munna S. Evaluation of phytochemical, antibacterial and free radical scavenging properties of azadirachta indica (neem) leaves. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6: 444-447.
10. Asmita S, Prerana V, Sudha. Design, development and characterization of liposomal neem gel. International Journal of pharmaceutical Sciences and Research. 2014; 5: 140-148.
11. Mahendra SK, Nityanand PV. Wrightia tinctoria R. Br.-a review on its ethnobotany, pharmacognosy and pharmacological profile. Journal of Coastal Life Medicine. 2014; 2:826-840.