Author(s):
Jagdish K Arun, Dharmajit Pattanayak, B. Shrivastava, Ramesh Adepu
Email(s):
Email ID Not Available
DOI:
10.5958/0974-360X.2020.00795.7 
Address:
Dr. Jagdish K Arun1, Dharmajit Pattanayak1, B. Shrivastava1, Dr. Ramesh Adepu2
1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan.
2Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet, Telangana.
*Corresponding Author
Published In:
Volume - 13,
Issue - 9,
Year - 2020
ABSTRACT:
Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity. The floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. Thus, floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. In this regard, this review aims to provide information of different floating and mucoadhesive approaches and their importance.
Cite this article:
Jagdish K Arun, Dharmajit Pattanayak, B. Shrivastava, Ramesh Adepu. A Systemic review on Floating Mucoadhesive drug Delivery system and its Present Scenario. Research J. Pharm. and Tech 2020; 13(9):4509-4516. doi: 10.5958/0974-360X.2020.00795.7
Cite(Electronic):
Jagdish K Arun, Dharmajit Pattanayak, B. Shrivastava, Ramesh Adepu. A Systemic review on Floating Mucoadhesive drug Delivery system and its Present Scenario. Research J. Pharm. and Tech 2020; 13(9):4509-4516. doi: 10.5958/0974-360X.2020.00795.7 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-83
REFERENCES:
1. Geetha A, Rajendrakumar J, Krishna Mohan CH, Sateesh V,Raju PN. A Review On Floating Drug Delivery Systems. 2012; 1(1):1-13.
2. Reddy L.H, Murthy R.S., Floating dosage systems in drug delivery, Crit. Rev. Ther. Drug Carr. Syst., 2002; 19: 553-585.
3. Dolas RT, Hosmani A, Bhandari A, Kumar B and Somvanshi S: Novel Sustained Release Gastroretentive Drug Delivery System: A Review. International Journal of Pharma Research and Development 2011; 2(1): 26-41.
4. Mathur P, Verma N: Floating drug delivery system: An innovative acceptable approach in gastroretentive drug delivery. Scholars Research Library 2010; 2(2): 257-70.
5. Hardenia SS, Jain A, Patel R and Kaushal A: Floating Drug Delivery Systems: A Review. Asian Journal of Pharmacy and Life Science 2011; 1(3): 284-93.
6. Kaushik Avinash, Dwivedi Abha, Kothari Praween, Govil Abhinav. Floating Drug Delivery System a Significant Tool for Stomach Specific Release of Cardiovascular Drugs. October-December 2012, 4(4): 116-129.
7. Khan AD, Bajpai M. Floating Drug Delivery System: An Overview. International Journal of PharmTech Research 2010; 2(4): 2497-2505.
8. Sharma N, Agarwal D, Gupta MK, Khinchi MA Comprehensive Review on Floating Drug Delivery System. International Journal of Research in Pharmaceutical and Biomedical Sciences 2011; 2(2): 428-441.
9. Nakagawa M, Ichikonda S, Sasai Y, Kuzuya H. Preparation of Floating Drug Delivery System By Plasma Technique. Chemical and Pharmaceutical Bulletin (The Pharmaceutical Society of Japan) 2006; 54: 514-518.
10. Goyal M, Prajapati R, Purohit KK, Mehta SC. Floating Drug Delievery System. Journal of Current Pharmaceutical Research 2011; 5(1): 7-18.
11. Bechgaard H, Ladefoged K., Distribution of pellets in gastrointestinal tract. The influence on transit time exerted by the density or diameter of pellets.J Pharm Pharmacol. 1978; 30: 690-692
12. Timmermans J, Gasnsbeka BV, Moes A. Accessing by gamma‐scintigraphy the in vivo buoyancy of dosage form having known size and floating force profiles as a function of time. Pharm Tech 1989; 1: 42‐51.
13. Gergogiannis YS, Rekkas DM, Dallos PP, Chailis NH. Floating and swelling characteristics of various excipients used in controlled release technology. Drug Dev Ind Pharm 1993; 19: 1061‐1081.
14. Cargill R, Cadwell LJ, Engle K, Fix JA, Porter PA, Gardner CR. Controlled gastric emptying: I. Effects of physical properties on gastric residence times of non disintegrating geometric shapes in beagle dogs. Pharm Res 1988; 5: 533‐536.
15. Shaikh R, Raghurai ST, James GM, David WA, Donnelly R. Mucoadhesive drug delivery systems. J of Pharm and BioalliedSci2011;3: 89-100.
16. Senthil KM. Mucoadhesive Buccal Drug Delivery System - An Overview.Int J Pharm & Tech 2012;4: 3951-3969.
17. Mamatha Y, Prasanth VV, Arun KS, Altaf BMS, Vandana Y (2012) Buccal Drug Delivery: A Technical Approach. J of Drug Delivery & Therapeutics 2: 326-329.
18. Bhowmik D, Niladry C (2013) Mucoadhesive Buccal Drug Delivery System- An over view. J of Advance Pharm EduAnd Res 3: 319-331
19. Khan Shahid, Verma Mayank, Aggarwal Geeta and Kumar S. L. Hari.Mucoadhesive Drug Delivery System: A Review.Volume 5, Issue 5, 392-405.
20. Andrews G.P., Laverty T.P., Jones D.S., Mucoadhesive polymeric platforms for controlled drug delivery, Eur. J. Pharm. Biopharm., 2009; 71: 505–518.
21. Sahoo CK, Nayak PK, Sarangi DK, Sahoo TK.A review on mucoadhesive drug delivery systems. International Journal of Universal Pharmacy and Bio Sciences 2013; 2(3):92-119.
22. V. V. Khutoryanskiy, Advances in Mucoadhesion and Mucoadhesive Polymers, Macromol. Biosci, 11, 2011, 748-764.
23. Yie W Chein. Novel drug delivery system, 2nd Ed, Marcel Jekker Inc. New York, 1992;1-3.
24. Sanjay Garg and Shringi Sharma. Gastro retentive drug delivery system.Pharmatech.2003; 160-166.
25. Sahoo CK, Dasari P, Dandamundi S , karnati N, Kokkula S, Patro MK. A Review on Floating Drug Delivery System. International Journal of Pharmaceutical Research and Development.2013; 4(11):1-16.
26. Whitehead L, Collet JH, Fell JT, Sharma HL, Smith AM. Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. J Control Release 1998; 55: 3‐12.