Author(s):
Bakthavachalam A, Remya P N, Damodharan N
Email(s):
bakthava.bc@gmail.com , remyan@srmist.edu.in
DOI:
10.5958/0974-360X.2020.00783.0 
Address:
Bakthavachalam A, Remya P N*, Damodharan N
Department of Pharmaceutics, SRM College of pharmacy, SRM Institute of Science and Technology, kattankulathur-603203.
*Corresponding Author
Published In:
Volume - 13,
Issue - 9,
Year - 2020
ABSTRACT:
Noble drug delivery or traditional drug delivery has failed to improve the bioavailability of drugs and also to reduce the toxicity of drugs. In recent years, targeted drug delivery system has gained its importance in delivering drug with low toxic levels and high bioavailability. Nanotechnology has created an revolution in the field of drug delivery. Especially solid lipid nano particles (SLNs) have been proven to be one of the best drug carries. SLNs have numerous applications in the prophylaxis of cancer, tuberculosis and they are used as adjutants in many vaccines. Preparation methods of SLNs include homogenization using pressure, ultra-sonication, solvent evaporation and its preparation depends upon the nature of drug. Bio distribution of drug is an challenge and it’s well managed by selecting the perfect route of drug administration. Characterization of drug is also important for SLNs to improve the bioavailability of drug and it includes different methods like Electronic microscopy, particle size determination along with its zeta potential.
Cite this article:
Bakthavachalam A, Remya P N, Damodharan N. Review on Solid lipid nanoparticles. Research J. Pharm. and Tech 2020; 13(9):4430-4434. doi: 10.5958/0974-360X.2020.00783.0
Cite(Electronic):
Bakthavachalam A, Remya P N, Damodharan N. Review on Solid lipid nanoparticles. Research J. Pharm. and Tech 2020; 13(9):4430-4434. doi: 10.5958/0974-360X.2020.00783.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-71
REFERENCES:
1. Pavankumar AR, Parthiban S (2014) A modern review on solid lipid nanoparticles as novel controlled drug delivery system. Ijrpns 3(4): 313-325.
2. C. Shah, V. Shah, U. Upadhyay, solid lipid nanoparticles: a review current pharma research, 1(4), 2011, 351-368.
3. R. Cavalli, M. R. Gasco, P. Chetoni, S. Burgalassi, Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin. International Journal Pharm, 238, 2002, 241 – 245.
4. N. K. Jain, Controlled and Novel Drug Delivery 1st Edition, (CBS Publishers and Distributors1997) 3-28.
5. Rivastigmine Tartrate Solid Lipid Nanoparticles Loaded Transdermal Film: An In vivo study, Ravi G, Vishal Gupta N, Balamuralidhara V, Vol-11, Pag 227-230, 2018, RJPT.
6. S.A. Wissing, R.H. Muller, Solid lipid nanoparticles (SLN) a novel carrier for U V blockers. Pharmazie 56, 2001, 783-786. C. Rudolph, U. Schillinger, A. Ortiz, K. Tabatt, C. Plank, R.H. Muller, Application of novel Solid lipid nanoparticles (SLN) - gene vector formulations based on a diametric HIV-1 VAT - peptide in vitro and in vivo.Pharmaceutic Res, 21, 2004, 1662-1669.
7. Effect of Lipids and Surfactants on Solid Lipid Nanoparticle Engineering, Baviskar Anagha, Hiremath Shivanand, Akul Manoj, Pawar Poonam, Vol- 4, Pag-521-526, 2011, RJPT.
8. P. Rabinarayan, S. Padilama, Production of Solid Lipid Nanoparticles-Drug Loading and Release Mechanism. Journal of Chemical and Pharmaceutical Research, 2(1), 2010, 211-227.
9. B. Siekmann, K. Westesen. Investigations on solid lipid nanoparticles prepared by precipitation in o/w emulsions. European J. Pharm. Biopharm, 43, 1996, 104-109.
10. S.H. Gohla, A. Dingler, Scaling up feasibility of the production of solid lipid nanoparticles (SLN). Pharmazie, 56, 2001, 61-63.
11. C. Schwarz, W. Mehnert, J.S. Lucks, R.H. Müller, Solid lipid nanoparticles (SLN) for controlled drug delivery: I. Production, characterization and sterilization. Journal of Controlled Relelease, 30, 1994, 83-96.
12. F. Lai, S.A. Wissing, R.H. Muller, A. M. FaddaArtemisia arborescensL essential oil-loaded solid lipid nanoparticles for potential agriculture application: Preparation and characterization. AAPS Pharm Sci Tech, 7, 2006, 21-27.
13. R.Pandey, S. Sharma, G.K. Khuller. Oral SLN Based antitubercular chemotherapy, Tuberculosis (Edinb) 85, 2005, 415-420.
14. Formulation, Characterization and Applications on Solid Lipid Nanoparticles – A Review., S. Harshavardhan Reddy, M. S. Umashankar, N. Damodharan., Vol- 11, Pag-5691-5700, 2018, RJPT.
15. Solid Lipid Nanoparticles – Preparation, Applications, Characterization, Uses in Various Cancer Therapies, Sachin J., N. Vishal Gupta., Vol-6, Pag-825-837, 2013. Research Journal of Pharmaceutics and Technology.
16. K. Ruckmani, M. Sivakumar, P.A. Ganeshkumar, Methotrexate loaded solid lipid nanoparticles (SLN) for effective treatment of carcinoma. Journal Nano sciences Nanotechnology, 6, 2006, 2991-2995.
17. R. Cortesi, E. Esposito, G. Luca, C.Nastruzzi.Production of lipospheres as carriers for bioactive compounds.Biomaterials, 23, 2002, 2283-2294.
18. S.C.Yang, L.F.Lu, Y. Cai, J.B. Zhu, B.W. Liang, Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. Journal of Control Release, 59, 1999, 299-307.
19. S. Pragati, S. Kuldeep, S. Ashok, Solid Lipid Nanoparticles: A Promising Drug Delivery Technology. International Journal of Pharmaceutical Sciences and Nanotechnology, 2(2), 2009, 509-516.
20. S. N. Mistry, P. K. Patel, P. D. Bharadia, V. M. Pandya, D. A. Modi, Novel Drug Delivery System for Lipophilic Agents: Solid Lipid Nanoparticles. IJPI’s Journal of Pharmaceutics and Cosmetology 1(4), 2011, 76-89.
21. Voriconazole Solid Lipid Nanoparticles: Optimization of Formulation and Process Parameters , Srikar Grandhi*, A. Prameela Rani, Raghuveer Pathuri, Vol- 11, 2018.
22. F. Lai, S.A. Wissing, R.H. Muller, A. M. FaddaArtemisia arborescensL essential oil-loaded solid lipid nanoparticles for potential agriculture application: Preparation and characterization. AAPS Pharm Sci Tech, 7, 2006, 21-27.
23. Formulation, Characterization and in vitro Evaluation of Methotrexate Solid Lipid Nanoparticles, Jameel Ahmed Mulla, Sarasija Suresh, Imtiyaz Ahmed Khazi, Vol-2, Pag-685-689, 2009, RJPT.
24. Quality by Design approach in the development of Solid Lipid Nanoparticles of Linagliptin, D. Krishna Veni, N. Vishal Gupta, Vol- 12, Pag 4454-4462, 2019, RJPT.
25. S. P. Vyas and R. K. Khar, Controlled Drug Delivery - Concepts and Advances, 1st Edition, (VallabhPrakashan 2002) 38-50.
26. P. K. Gupta, J. K. Pandit, A. Kumar and P. Swaroop, S.gupta, T. Ph. Res., 3, 2010117-138.
27. B. Lu, S.B. Xiong, H. Yang, X.D. Yin, R.S. Chao, Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymphnode metastases. European Journal of Pharm. Sciences, 28, 2006, 86-95.
28. A Review on solid Lipid Nanoparticles, D. Thulasi Ram*, Subhashis Debnath, M. Niranjan Babu, T. Chakradhar Nath, Thejeswi B. Vol-5, 2012. RJPT.
29. Quality by Design approach in the development of Solid Lipid Nanoparticles of Linagliptin, D. Krishna Veni, N. Vishal Gupta, Vol- 12, Pag 4454-4462, 2019, RJPT.
30. M.C. Santos, W. Mehnert, M. Schaller, Drug targeting by solid lipid nanoparticles for dermal use. Journal Drug Target, 10, 2002, 489-495.
31. Isotretinoin-Loaded Solid-Lipid Nanoparticles: A Sound Strategy for Skin Targeting, Surbhi Sharma*, M.S. Ashawat and N.S. Solanki, Vol- 5, 2011, RJPT.
32. H. Chen, X. Chang, D. Du, W. Liu, J. Liu, Podophyllotoxin- loaded solid lipid nanoparticles for epidermal targeting. Journal of Control Release 110, 2006, 296-306.
33. V. Jenning, S. Gohla, Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. Journal of Control Release, 66, 2000, 115-126.
34. F. Lai, S.A. Wissing, R.H. Muller, A. M. FaddaArtemisia arborescensL essential oil-loaded solid lipid nanoparticles for potential agriculture application: Preparation and characterization. AAPS Pharm Sci Tech, 7, 2006, 21-27.
35. Y. Wang, W. Wu, In situ evading of phagocytic uptake of stealth solid lipid nanoparticles by mouse peritoneal macrophages. Drug Delivery, 13, 2006, 189-192.
36. Formulation and Evaluation of Glyceryl Behenate based Solid Lipid Nanoparticles for the delivery of Donepezil to brain through Nasal Route, Mohd Yasir, Iti Chauhan, Misbahu J. Haji, Abdurazak J. Tural, Prasoon K. Saxena, Vol-11, Pag 2836-2844. 2018. RJPT.