ABSTRACT:
Isoniazid, Hydralazine hydrochloride and Dihydralazine sulphate are some commercial hydrazine-based drugs. This paper reports an investigation of the determination of these drugs in their commercial formulations for the purpose of quality control. A differential pulse polarographic (DPP) method based on the electrochemical reaction at dropping mercury electrode (DME) of drug dithiocarbazate derivative (formed from their reaction with carbon disulphide) yielding analytically useful waves and peaks at -1.10 V, -1.25 V and -0.94 V (vs SCE) respectively has been developed. The results have been calculated on the basis of a calibration graph drawn between drug concentration and wave current which were linear upto 40, 48 and 40 µg ml-1 respectively of above drug compounds. The method has been extended to the analysis of some commercial drug formulations based on them. The recoveries of the drugs from pharmaceutical formulations were in the range 98.0-100.5 % of the nominal content with RSDs in the range 0.23-1.94% indicating good accuracy and precision of the method.
Cite this article:
Jasvir Singh. Pulse Polarographic determination of Isoniazid, Hydralazine hydrochloride and Dihydralazine sulphate based commercial hydrazine drugs. Research J. Pharm. and Tech 2020; 13(9):4061-4066. doi: 10.5958/0974-360X.2020.00718.0
Cite(Electronic):
Jasvir Singh. Pulse Polarographic determination of Isoniazid, Hydralazine hydrochloride and Dihydralazine sulphate based commercial hydrazine drugs. Research J. Pharm. and Tech 2020; 13(9):4061-4066. doi: 10.5958/0974-360X.2020.00718.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-6
REFERENCES:
1. Patel R, Bhandari A. Synthesis and Antimicrobial Screening of Some 4-Substituted-3-Chloro-2-Oxo-Azetidine Derivatives. Asian J. Research Chem. 2014; 7(11): 950-953.
2. Manikandan A, Rajasekar K, Gomadurai T, Sathiyamoorthy B, Sudhakar P. Microwave assisted synthesis, spectral, bio-potential and antituberculosis activities of Co (II) complex with Isoniazid and benzoate ion. Asian J. Research Chem. 2018; 11(2):467-471.
3. George M, Nagaraja KS, Balasubramanian N. Talanta. 2008; 75(1): 27-31.
4. Almani KF, Laghari MGH, Memon AH, Rind FMA, Mughal UR, Maheshwari ML and. Khuhawer MY. Asian Journal of Chemistry. 2013; 25 (5): 2522-2526.
5. Adegoke AO, Nwoke CE. Journal of the Iranian Chemical Society. 2008; 5(2): 316-323.
6. Karimi MA, Mazloum-Ardakani M, Mashhadizadeh, MH and Banifatemeh F. Croat. Chem. Acta. 2009; 82:729-738.
7. Khalid A. Attia, Mohammed W. Nassar, Hamed H. Abou-Seada, Ahmad A. Mohamad and Ragab A. Said. IJPSR. 2014; 5(9): 3627-3632.
8. Kosyakov DS, Amosov AS, Ul’yanovskii NV, Ladesov AV, Khabarov Yu. G and Shpigun AO. Journal of Analytical Chemistry. 2017; 72 (2): 171–177.
9. Dhara Vashi, Suresh Kumar. Impurity Identification and Characterization of some Anti-Diabetic Drugs using various Analytical Methods. Asian J. Pharm. Res. 2019; 9(4):243-248.
10. Shubhangi C. Daswadkar, Jyoti D Gaikwad. Determination of Concentration of Zolmitriptan in Solid Dosage Form by UV Spectroscopic Method. Asian J. Pharm. Tech. 2019; 9(4):244-248.
11. Rajan V. Rele, Prathamesh P. Tiwatane. Derivative UV Spectrophotometric Method for Validation of Metformin hydrochloride in Bulk and Pharmaceutical Dosage Form. Asian J. Research Chem. 2019; 12(6):351-354.
12. Sandip A. Bandgar, Namdeo R. Jadhav. Validated UV Spectrophotometric method for Estimation of Simvastatin in Bulk and Pharmaceutical Formulation. Research J. Pharm. and Tech. 2019; 12(12): 5745-5748.
13. Gopalasatheeskumar K, Ariharasiva Kumar G, Sengottuvel T, Sanish Devan V, Srividhya V. Quantification of Total Phenolic and Flavonoid content in leaves of Cucumis melo var agrestis using UV- spectrophotometer. Asian J. Research Chem. 2019; 12(6):33.
14. Yuvaraj TV, Unnissa SH, Surendiran , Ur rahman MA, Binumon, V. Synthesis and Antimicrobial Screening of Some Novel Cinnoline Derivatives. Asian J. Research Chem. 2010; 3(4): 853-858.
15. Madhavi R., Mohana Krishna A., Shobha Rani G., Mounika D. Isoniazid: A Review of Analytical Methods. Asian J. Pharm. Ana. 5(1): Jan.- March 2014; Page 41-45.
16. Matíes R, Arias JJ, Jiménez F and Román F. Analytical Letters. 1997; 30(3): 633-644.
17. Arshadi M, Nilsson C, Magnusson B. J Chromatogr A. 2006; 1125 (2): 229-233.
18. Oh JA, Park JH, Shi HS. Anal Chim Acta, 2013; 769: 79-83.
19. McAdam K, Kimpton H, Essen S, et al., Chemistry Central Journal. 2015; 9:13.
20. Jayashree V, Velraj M. HPTLC Fingerprinting Profile and GC-MS Analysis of Aqueous extract of Alstonia scholaris Linn. Bark. Research J. Pharm. and Tech. 2019; 12(12): 5706-5710.
21. Ananthalakshmi R, Rajarathinam SRX, Sadiq AM, Poongothai A. Phytochemical profiling of Luffa acutangula peel extract using GCMS Study. Research J. Pharm. and Tech. 2019; 12(12): 6071-6074.
22. Amosov AS, Ul’yanovskii NV, Kosyakov DS, Shpigun O. Journal of Analytical Chemistry.2018; 3 (5): 497–503.
23. Punam S. Desai, Rajeshwar V. Chavan, Nikita B. Amane, Sanmati D. Shete, Archana R. Dhole. High Performance Liquid Chromatography – A Validation View. Asian J. Pharm. Ana. 2019; 9(4):232-236.
24. Bichala PK, Suthakaran R, Shankar C. Method Development and Validation for Simultaneous determination of Isoniaizid and Atazanavir in Pure and Pharmaceutical Formulation by using HPLC. Asian J. Pharm. Ana. 2018; 8(4): 203-20.
25. Zhuoling An, Pengfei Li, Xi Zhang and Lihong Liu. 2014; 37(9): 1212-1225.
26. Jin-Aa Oh and Ho-Sang Shin. Journal of Liquid Chromatography and Related Technologies. 2015; 38 (17): 1616-1621.
27. Liu B, He Y, Duan C, Li N and Cui H, Photochem H. Photobiol. 2011; A, 217: 62-67.
28. Wen-Chu Yang, Ai-Min Yu, Yi-Qing Dai and Hong-Yuan Chen, Analytical Letters, 33 (15), 3343-3353 (2000)
29. Jun Liu, Weihong Zhou, Tianyan You, Fenglei Li, Erkang Wang, Shaojun Dong. Analytical Chemistry. 1996; 68 (19): 3350-3353.
30. Salimi A, Miranzadeh L and Hallaj R. Talanta. 2008; 75: 147.
31. Khodadadian M, Jalili R, Bahrami MT, Bahrami G. Iran J Pharm Res. Autumn. 2017; 16(4): 1312–1319.
32. Pinter JS, Brown KL, DeYoung, PA and Peaslee GF. Talanta. 2007; 71(3):1219-1225.
33. Smolenkov AD, Chernobrovkina AV, Smirnov RS, Chernobrovkin MG and Shpigun OA. International Journal of Environmental Analytical Chemistry, 2013; 93 (12): 1286-1295.
34. Mori N, Tanaka K, Xu Q, Ikedo M, Taoda H and Hu W. J. Chromatogr. A. 2004; 135-139
35. Swamy N, Basavaiah NK, and Vinay KB. J Anal Chem. 2015; 70: 696-699.
36. Gojon C, Dureault B, Hovnanian N and Guizard C. Sens. Actuators. 1997; B 38: 154-162.
37. Pharmacopoeia of India. Published by Controller of Publication, New Delhi, IIIrd Ed., 1985; Vol. I: pp. 243-268.
38. British Pharmacopoeia. HM Stationery London, 1988; Vol. 11: pp. 982-983.
39. United State Pharmacopoeia, XIXth Revision, National Formulary, XVIth Ed., USP. Conv., Rockville MD. 1985; pp. 815.
40. Pharmacopoeia of India. Published by Controller of Publication, New Delhi, 3rd Edn. 1985; Vol. I: pp. 243-26.