Author(s): Sasikala M, Mohan S, Gokilambal V, Mymoona S, Hari P

Email(s): sasikalampharm@gmail.com

DOI: 10.5958/0974-360X.2020.00764.7   

Address: Sasikala M1,2*, Mohan S1, Gokilambal V1, Mymoona S1, Hari P1
1Karpagam College of Pharmacy, Coimbatore - 641032, Tamil Nadu, India.
2Faculty of Pharmacy, Karpagam Academy of Higher Education, Karpagam University, Coimbatore - 641021, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 9,     Year - 2020


ABSTRACT:
Aim and objective: To develop and validate a simple accurate and precise UV-spectrophotometric method to determine the degradation pathway of Oseltamivir in bulk form. Methodology: Separation of the drug from its degradation product was achieved by UV and scanned between 200-400nm. Oseltamivir was subjected to stress condition such as acid hydrolysis, alkali hydrolysis, oxidation, photolysis and thermal degradation. The samples were analyzed. Results: The maximum absorbance was found at 216nm and found to be linear over the range of 5-30µg/ml with good correlation co-efficient 0.999. Major degradation was observed in photolysis, oxidative and alkali degradation. Conclusion: The UV spectrophotometric method for Oseltamivir in the bulk form was developed and validated.


Cite this article:
Sasikala M, Mohan S, Gokilambal V, Mymoona S, Hari P. Validated UV-Visible Spectroscopic Analytical method development and stability studies on Oseltamivir. Research J. Pharm. and Tech 2020; 13(9):4323-4328. doi: 10.5958/0974-360X.2020.00764.7

Cite(Electronic):
Sasikala M, Mohan S, Gokilambal V, Mymoona S, Hari P. Validated UV-Visible Spectroscopic Analytical method development and stability studies on Oseltamivir. Research J. Pharm. and Tech 2020; 13(9):4323-4328. doi: 10.5958/0974-360X.2020.00764.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-52


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DOI: 10.5958/0974-360X 

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