Author(s):
Thilagar Gobinath, Kannan Kaviya, Samuthirapandian Ravichandran
Email(s):
sravicas@gmail.com
DOI:
10.5958/0974-360X.2020.00746.5 
Address:
Thilagar Gobinath1, Kannan Kaviya2, Samuthirapandian Ravichandran1*
1CAS in Marine Biology, Annamalai University, Parangipettai -608502, Tamil Nadu, India.
2Department of Biochemistry, Bharathidasan University, Tiruchirappalli, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 9,
Year - 2020
ABSTRACT:
The present investigation elaborates the energy efficient synthesis of chitosan/Ulva lactuca polysaccharide hydrogel impregnated with copper (II) (Cu-CS/ULP) for wound dressing applications. We successfully characterized the prepared hydrogel using FTIR, SEM, TG-DTA and swelling analysis. Compare to chitosan/U.lactuca polysaccharide hydrogel (CS/ULP), the Cu-CS/ULP hydrogel show a similar framework with the best mechanical properties. The whole blood clotting examination shows that the copper (II) can expand the blood clotting rates of the CS/ULP hydrogel. Free radical scavenging activity and prevention of protein degradation confirmed by DPPH and protein degradation assays. The released copper (II) from Cu-CS/ULP hydrogel exhibited a strong antibacterial activity against Gram-negative (Escherichia coli and Klebsiella pneumoniae) and Gram-positive (Bacillus subtilis and Staphylococcus aureus). Cu-CS/ULP hydrogel showed a significant activity in biofilm inhibition mass compared to that of CS/ULP. The present suggested that the copper (II) loaded CS/ULP hydrogel is a promising biomaterial for wound dressing application.
Cite this article:
Thilagar Gobinath, Kannan Kaviya, Samuthirapandian Ravichandran. Chitosan/Ulva lactuca polysaccharide Hydrogel containing copper (II) beneficial for Biofilm-associated wound infection: Formulation Characterizations and in vitro study. Research J. Pharm. and Tech 2020; 13(9):4224-4230. doi: 10.5958/0974-360X.2020.00746.5
Cite(Electronic):
Thilagar Gobinath, Kannan Kaviya, Samuthirapandian Ravichandran. Chitosan/Ulva lactuca polysaccharide Hydrogel containing copper (II) beneficial for Biofilm-associated wound infection: Formulation Characterizations and in vitro study. Research J. Pharm. and Tech 2020; 13(9):4224-4230. doi: 10.5958/0974-360X.2020.00746.5 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-34
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