Objective: The objective of this study was to formulate floating tablets (GRDDS) of Ritonavir using wet granulation technique to increase its bioavailability and the gastric residence time of the dosage form. Methods: The Ritonavir tablets were prepared by wet granulation method. The tablets were prepared by using two different grades of polymers i.e; HPMC K 15M and HPMC K 4M which act as a release retardant polymer. Sodium bi carbonate (NaHCO3) was used as a gas degenerating agent and MCC (Micro crystalline cellulose) was used as a diluent. Solution of gelatin and ethyl cellulose was used as a binder in the preparation of formulation. The final mixing was done by adding talc and magnesium stearate to the granules. Then the prepared formulation were subjected to some evaluation parameters like hardness, friability, weight variation, drug content, buoyancy property, drug release study etc. Results: In the FT-IR study it was revealed that there is no interaction between the drug and excipients. The formulation which containing the combination of HPMC K 15M polymer and Sodium bi carbonate shows good drug release pattern with less floating lag time and good floating duration. Conclusion: The in vitro drug release pattern of Ritonavir floating tablets was fitted to different kinetic models which showed the highest regression for Higuchi order kinetics.
Cite this article:
Jahnabi Sarmah, Ananta Choudhury. Formulation and Evaluation of Gastro Retentive Floating Tablets of Ritonavir. Research J. Pharm. and Tech 2020; 13(9):4099-4104. doi: 10.5958/0974-360X.2020.00724.6
Jahnabi Sarmah, Ananta Choudhury. Formulation and Evaluation of Gastro Retentive Floating Tablets of Ritonavir. Research J. Pharm. and Tech 2020; 13(9):4099-4104. doi: 10.5958/0974-360X.2020.00724.6 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-9-12
1. Garg S and Sharma S. Gastro retentive drug delivery system in: Drug delivery oral, Business Brief.: Pharmatech 2003; 3(1):160-166.
2. Rouge N, Buri P, Doeilkar E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int J Pharm 1996; 136: 117-139.
3. Fell JT, Whitehead L, Collet H. Prolonged gastric retension using floating dosage forms. Pharm Technol 2000; 24 (3): 82-90.
4. Matharu RS, Sanghvi NM. Novel drug delivery system of captopril. Drug Dev Ind Pharm. 1992; 18: 1567-1574.
5. Fell JT. Delivery system for targeting to specific sites in the gastrointestinal tract. J Pharmacol.1999; 51: 41.
6. Baumgartner S, Kristil J, Vrecer F et al. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000; 195 (1-2): 125-135.
7. Moses AJ. Gastro Retentive Dosage Forms: Critical review. Ther Drug Carier Syst 1993; 109(2): 143-195.
8. Tortora GJ and Derrickson B. Principles of Anatomy and Physiology. 11th ed. John Wiley & Sons, Inc. 2006:895-948.
9. Washington N, Washington C, Wilson CG.2011 Physiological Pharmaceutics II, Taylor and Francis, New York. 2015; 5:110-119.
10. Bannister LH, Alimentary system, in: Williams PL. Gray’s Anatomy. 38thed, New York: Churchill Livingstone, 1995, 1683–1812.
11. Desai S. A Novel Floating Controlled Release Drug Delivery System Based on a Dried Gel Matrix Network [master’s thesis].Jamaica: NY, St John’s University; 1984.
12. Vantrappen GR, Peeters TL, Janssens J. The secretory component of inter digestive migratory motor complex in man. Scand J Gastroenterol. 1979; 14(6): 663-667.
13. Wilson CG, Washington N, The stomach: its role in oral drug delivery. In: Rubinstein MH, ed. Physiological Pharmacetical:Biological Barriers to Drug Absorption. Chichester; UK: Ellis Horwood; 1989: 47-70.
14. Sarawade A, Ratnaparkhi MP, Chaudhari S. An Overview Floating Drug Delivery System. Interrnational Journal of Research and Development in Pharmacy and Life Sciences. 2014; 3(5): 1106-1115.
15. Arora S, Ali A, Ahuja A et al. Floating drug delivery systems: A review. AAPS PharmSciTech 2005; 6(3): 372‐390.
16. Law D, Krill SL, Schmitt EA et al. Physicochemical Consideration in the preparation of Amorphous Ritonavir- Poly(ethylene glycol) 8000 Solid Dispersions. J Pharm Sci. 2001; 90(8): 1015-25.
17. Xiaoqiang X, Minjie S, Feng Z et al. Floating matrix dosage form for phenol porlamine hydrochloride based on gas generating agent :in vitro and in-vivo evaluation in healthy volunteers, Int. J. Pharm. 2006; 310: 139-14.
18. Choudhury A, Das S, Bahadur S et al. Development and characterization extended release gastro retentive drug delivery. Journal of Pharmacy Research 2009; 2(10): 1557-1560.
19. Connors KA, Amidon GL, Stell VJ. Chemical Stability of Pharmaceuticals. 2nd ed. Wiley, New York. 1986.
20. Ziyaur Rahman, Mushir Ali, Khar RK. Design and evaluation of bilayer floating tablet of Captopril. Acta Parma. 2006; 56(1): 49-57.
21. Rekhi GS, Nellore RV, Hussain AS et al. Identification of critical formulation and processing variables for metoprolol tartrate extended-release (ER) matrix tablets, J Control Release 1999; 59: 327-342.
22. Shishu, Aggarwal N. Preparation of hydrogels of griseofulvin for dermal application, Int J Pharm. 2006; 326(1-2): 20-4.
23. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery systems, Expert Opinion on Drug Delivery 2006; 3(2): 217-233.
24. Dave B.S, Amin A.F, Patel M.M. Gastro retentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. AAPS Pharm Sci Tech. 2004 8; 5(2): 34.
25. Ye ZW, Rombout P, Remon JP et al. Correlation between the permeability of metoprolol tartrate through plasticized isolated ethyl cellulose/ hydroxyl propyl methyl cellulose films and drug release from reservoir pellets, Eur J Pharmaceut. Biopharmaceut. 2007; 67: 485-490.
26. Narendra C, Srinath MS, B. Prakash Rao, Development of three layered buccal compact containing Metoprolol tartrate by statistical optimization technique. Int J Pharmaceut. 2005; 304(1-4): 102- 14.
27. Sutananta W, Craig DQM, Newton JM. The effects of aging and thermal behaviour and mechanical properties of pharmaceutical glycerides. Int J Pharm 1994; 111:51-62.