Author(s): P. Palanisamy, B. Jaykar, Margret Chandira, B.S. Venkateswarlu, Prabakaran. M

Email(s): palanisamy2907@gmail.com

DOI: 10.5958/0974-360X.2020.00723.4   

Address: P. Palanisamy*, B. Jaykar, Margret Chandira, B.S. Venkateswarlu, Prabakaran. M
Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem (D.T), Tamil Nadu (State), India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 9,     Year - 2020


ABSTRACT:
The present investigation concerns the development of immediate release tablet of Raloxifene Hydrochloride by Hot Melt Technology using hydrophilic polymer in various ratio. Seven batch of hot melt were fabricated containing Raloxifene Hydrochloride and Polyethylene Glycol. From the all batch of hot melt one batch were selected for formulation of immediate release tablet. Raloxifene Hydrochloride immediate release tablet was prepared, by using polyplasdone a super disintegrant and pharmatose 200m as a filler. Preformulation study was performed like Angle of repose, Bulk density, Tapped density, Carr's index Hausner ratio. Tablet were prepared by wet granulation technique, the evaluation study were performed like hardness, thickness, friability, assay, content uniformity, weight variation, disintegration time, in-vitro drug release and stability. Seven formulation were prepared, Formulation F6 (Raloxifene Hydrochloride and Polyethylene Glycol in ratio 1:0.5) were optimized, having similar disintegration time and in vitro release profile compare to reference.


Cite this article:
P. Palanisamy, B. Jaykar, Margret Chandira, B.S. Venkateswarlu, Prabakaran. M. Pharmacokinetic Modifications of Immediate release tablets of Raloxifene Hydrochloride by hot melt Technology. Research J. Pharm. and Tech 2020; 13(9):4092-4098. doi: 10.5958/0974-360X.2020.00723.4


REFERENCES:
1.    Gilbert S. Banker, Christopar T. Rhodes. “Modern Pharmaceutics”, Fourth edition, 2002; 287.
2.    Liberman H.A. “Pharmaceuticals Dosage Forms; Tablets” Secound Edition, Vol.I, 285.
3.    Lachman, L. and Liberman, H .A. “Theory and practice of industrial pharmacy” Third Edition, 1991; 198.
4.    Howard C. Ansel, Nicholas G.popvich, Loyd V.Allen, Jr. “Pharmaceutical Dosage Forms and Drug delivery Systems”, First Edition, 1995; 228.
5.    Banker, S.G, .Andersion, S.N. Section III Pharmaceutical Dosage Form, 1999; 290 -328.
6.    "USP", XXIV, The United State Pharmacopeia convention, Inc., Rockville, Mary Land, 2007; 1941-1960.
7.    USP", XXIV, NF 19, United State Pharmacopeia convention, Inc., Rockville, 2007; 890.
8.    "Indian Pharmacopeia", Vol II, Controller of Publication, Delhi. 1996; 82-83.
9.    Lloyd G.R, Craig D.Q.M, Smith A. An Investigation into the Melting Behavior of Binary Mixes and Solid Dispersions of Paracetamol and PEG 4000. J. Pharm.sci. 1997; 86 (9): 991-996.
10.    Baboota S, Agarwal S.P. Inclusion complexation of meloxicam with β-Cyclodextrin. Indian J. Pharm.Sci. 2002; 64: 408-411.
11.    Chokshi R, Zia H. Hot Melt Extrusion Technique-a review. Iranian J Pharm. 2004; 3: 3-16.
12.    Heng WW, Wong TW. Melt Processes for oral solid dosage form. Pharm. Tech. 2005; 1-6.
13.    Wadke DA, Serajuddin ATM, Jacobson H. Prefulation testing. In: Liberman HA, Lachman L, Schwartz JB,eds. Pharmaceutical Dosage Form: Tablets, Marcel Dekker, New York. 1989; 1-73.
14.    Goldberg AH, Gibaldi M, Kanig JL. Incressing dissolution rates and GI Absorption. J Pharm Sci. 1966; 55: 487-492.
15.    Lachman L, Liberman H.A. Theory and practice of industrial pharmacy. Third Edition, 1991; 198.
16.    Howard C. Ansel, Nicholas G.popvich,Loyd V.Allen, Jr. Pharmaceutical Dosage Forms and Drug delivery Systems. First Edition, 1995; 228.
17.    Gilbert S. Banker, Christopar T. Rhodes. Modern Pharmaceutics. Fourth edition, 2002; 302.
18.    In-vitro Dissolution, The United States Pharmacopoeia, United States Pharmacy.
19.    Jain N. K. Pharmaceuticals product development. second edition, 2001; 61.
20.    Dhenge, Ranjit M, Washino, Kimiaki, Cartwright, James J, Hounslow, Michael J, Salman, Agba D. Twin screw granulation using conveying screws: Effects of viscosity of granulation liquids and flow of powders. Powder Technology. 2012; 238: 77–90.
21.    "USP", XXIV, The United State Pharmacopeia convention, Inc., Rockville, Mary Land, 2007; 3472-3474.
22.    "European Pharmacopoeia". general monograph, 2007; 5325-5326.

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