Author(s): Maruthi R, Chandan R.S, Barath M, G Naveen Datta, Merryl D’silva, Kajal Kumari M, Farhan Ahmad, Geetha R

Email(s): rschandan@jssuni.edu.in

DOI: 10.5958/0974-360X.2020.00713.1   

Address: Maruthi R1, Chandan R.S*, Barath M1, Mr. G Naveen Datta2, Ms. Merryl D’silva2, Ms. Kajal Kumari M3, Mr. Farhan Ahmad6, Ms. Geetha R7
1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru- Karnataka, India 570015.
2Department of Pharmaceutics, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru- Karnataka, India 570015.
3Department of Pharmacy Practise, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru- Karnataka, India 570015.
*Corresponding Author

Published In:   Volume - 13,      Issue - 9,     Year - 2020


ABSTRACT:
To estimate Teneligliptin by Ultra-Fast Liquid Chromatographic (RP-UFLC), a fast, reliable, and cost-effective UFLC method was developed. The approximate flowing rate was 1.0 mL/minfor the Phenomenex Kinetex column C18 (250mmx 4.6mm. 5 Micron) with MeOH and ACN (60:40 v/v) as a portable stream. A PDA detector at 246 nm was used to track the eluent. Teneligliptin elutes at 4.938 minutes of the processing period. The proposed method has a linearity of 10 to 50µg/ml concentration range; the calibration diagram is continuous and 0.9942 percent for the correlations variable (r2). For the suggested procedure, both LOD and LOQ are measured as 0.097 and 1.023µg/mL, respectively. In the pharmaceutical product, the drug has been under the states of stress conditions acidic, alkaline, degradation, Ultraviolet, and heat stress. The degradation product from the Teneligliptin was well solved, and thus the stability of this method was demonstrated. The process was tested in compliance with ICH criteria of device suitability, linearity, reliability, consistency, and robustness.


Cite this article:
Maruthi R, Chandan R.S, Barath M, G Naveen Datta, Merryl D’silva, Kajal Kumari M, Farhan Ahmad, Geetha R. Analytical Method development and Validation of Teneligliptin by RP-UFLC. Research J. Pharm. and Tech 2020; 13(9):4035-4040. doi: 10.5958/0974-360X.2020.00713.1


REFERENCES:
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