Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat
Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat
University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
Volume - 13,
Issue - 8,
Year - 2020
Exposure therapy in the intervention of anxiety treatment and management of anxiety disorders proved to be the most effective. This therapy exposes persons with an anxiety disorder to fear and anxiety-provoking situations, whereby they gain new experiences, which reduces their fear and anxiety. Generally, the amygdala a part of the brain responsible for conditioned fear and anxiety responses such as flee responses, here the new experience and exposure can retrain the amygdala to respond fight rather than flee. The purpose of the article is to promote awareness regarding exposure therapy used in the behavioural interventions of anxiety disorder signifies its role in retraining the amygdala, to be free from conditioned fear. This literature review was completed using electronic databases, an Ovid Medline and PsycINFO search. The current study analysis reviewed 40 full-text articles from the year 1993 to 2015. The search was conducted using keywords such as exposure therapy, amygdala, and anxiety disorders. This article bases on brain behaviour in flight and fight responses. In a nutshell, the article indicates that providing new experiences to the amygdala can bring new responses to fear and anxiety situations.
Cite this article:
Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat. A Brief Literature Review Retraining Amygdala to Substitute its Irrational Conditioned Fear and Anxiety Responses with New Learning Experiences. Research J. Pharm. and Tech. 2020; 13(8):3987-3991. doi: 10.5958/0974-360X.2020.00705.2
Vidya Bhagat, Nordin Simbak, Rohayah Husain, Khairi Che Mat. A Brief Literature Review Retraining Amygdala to Substitute its Irrational Conditioned Fear and Anxiety Responses with New Learning Experiences. Research J. Pharm. and Tech. 2020; 13(8):3987-3991. doi: 10.5958/0974-360X.2020.00705.2 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-8-78
1. Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. Optimizing inhibitory learning during exposure therapy. Behaviour Research and Therapy. 2008; 46(1):5-27.
2. Sylvers P, Lilienfeld SO, LaPrairie JL. Differences between trait fear and trait anxiety: Implications for psychopathology. Clinical Psychology Review. 2011; 31(1):122-37.
3. Furmark T, Fischer H, Wik G, Larsson M, Fredrikson M. The amygdala and individual differences in human fear conditioning. Neuroreport. 1997; 8(18):3957-60.
4. Etkin A, Wager TD. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry. 2007; 164(10):1476-88.
5. Goldstein DS. Adrenal responses to stress. Cell Mol Neurobiology. 2010; 30(8):1433-40.
6. María José De Rosa, Tania Veuthey, Jeremy Florman, Jeff Grant, María Gabriela Blanco, Natalia Andersen, Jamie Donnelly, Diego Rayes, Mark J. Alkema. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. Nature, 2019; 573 (7772): 135
7. Roelofs K, Hagenaars MA, Stins J. 2010. Facing freeze: social threat induces bodily freeze in humans. Psych. Sci. 21, 1575–1581.
8. Fonzo GA, Ramsawh HJ, Flagan TM, et al. Common and disorder-specific neural responses to emotional faces in generalised anxiety, social anxiety and panic disorders. Br J Psychiatry. 2015; 206(3):206–215.
9. Forster GL, Novick AM, Scholl JL, Watt MJ. The role of the amygdala in anxiety disorders. The amygdala-a discrete multi-tasking Manager. 2012 Dec 19:61-102.
10. Forster GL, Novick AM, Scholl JL, Watt MJ. The role of the amygdala in anxiety disorders. The amygdala-a discrete multitasking Manager. 2012: 61-102.
11. Gogtay N, et al. Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences. 2004; 101(21):8174-9.
12. Carlson JM, Greenberg T, Rubin D, Mujica-Parodi LR. Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation. Social Cognitive and Affective Neuroscience. 2011 Jan 1; 6(1):74-81.
13. Stein MB, Simmons AN, Feinstein JS, Paulus MP. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. American Journal of Psychiatry. 2007; 164(2):318-27.
14. Bishop S, Duncan J, Brett M, Lawrence AD. Prefrontal cortical function and anxiety: controlling attention to threat-related stimuli. Nature Neuroscience. 2004; 7(2):184-8.
15. Etkin A, et al. Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron. 2004; 44(6):1043-55.
16. Dickie EW, Armony JL. Amygdala responses to unattended fearful faces: interaction between sex and trait anxiety. Psychiatry Research: Neuroimaging. 2008; 162(1):51-7.
17. Hyde LW, Gorka A, Manuck SB, Hariri AR. Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety. Neuropsychologia.2011 49(4):651-6.
18. Yoon KL, Fitzgerald DA, Angstadt M, McCarron RA, Phan KL. Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Research: Neuroimaging. 2007; 154(1):93-8.
19. Carré JM, Fisher PM, Manuck SB, Hariri AR. Interaction between trait anxiety and trait anger predict amygdala reactivity to angry facial expressions in men but not women. Social Cognitive and Affective Neuroscience. 2012; 7(2):213-21.
20. Phelps EA, O'Connor KJ, Gatenby JC, Gore JC, Grillon C, Davis M. Activation of the left amygdala to a cognitive representation of fear. Nature Neuroscience. 2001; 4(4):437-41.
21. Lehmann H, Treit D, Parent MB. Spared anterograde memory for shock-probe fear conditioning after inactivation of the amygdala. Learning and Memory. 2003 Jul 1; 10(4):261-9.
22. Davis M, Whalen PJ. The amygdala: vigilance and emotion. Molecular Psychiatry. 2001 Jan; 6(1):13-34.
23. Maren S. Neurobiology of Pavlovian fear conditioning. Annual Review of Neuroscience. 2001 Mar; 24(1):897-931.
24. Blair HT, Schafe GE, Bauer EP, Rodrigues SM, LeDoux JE. Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learning and Memory. 2001; 8(5):229-42.
25. Quirk GJ, Repa JC, LeDoux JE. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron. 1995; 15(5):1029-39.
26. Espie C. Overcoming insomnia and sleep problems: A self-help guide using cognitive behavioural techniques. Robinson; 2012 Nov 1.
27. Baillie AJ, Rapee RM. Panic attacks as risk markers for mental disorders. Social Psychiatry and Psychiatric Epidemiology. 2005 Mar 1; 40(3):240-4.
28. Blanchard DC, Griebel G, Blanchard RJ. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neuroscience and Biobehavioral Reviews. 2001 May 1; 25(3):205-18.
29.  Linehan MM. Skills training manual for treating borderline personality disorder. Guilford Press; 1993.
30. Linehan M. DBT? Skills Training Manual. Guilford Publications; 2014.
31. Mueller D, Cahill SP. Noradrenergic modulation of extinction learning and exposure therapy. Behavioral Brain Research. 2010 Mar 17; 208(1):1-1.