Author(s): Tris Harni Pebriani, Rurie Ratna Shantiningsih, Ronny Martien

Email(s): ronnymartien@ugm.ac.id

DOI: 10.5958/0974-360X.2020.00681.2   

Address: Tris Harni Pebriani1,3, Rurie Ratna Shantiningsih2, Ronny Martien1
1Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
2Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, Indonesia.
3Yayasan Pharmasi College of Pharmacy, Semarang 50193, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 8,     Year - 2020


ABSTRACT:
Beta carotene applied to the mucoadhesive gingiva patch was not significantly reduced the micronucleus as the negative effects of panoramic radiographic exposure on patients dental examination. Its solubility in the patch matrix was very low. Development of beta carotene nanoemulsion using combination of Rice Bran Oil (8%), Tween 80 (85%) and PEG 400 (7%) is expected to increase the solubility that dispersed into the mucoadhesive patch preparation. Beta carotene nanoemulsion mucoadhesive patches produced has a weight 91.0 ? 0.2 mg; thickness 0.18 ? 0.01 mm; folding endurance more than 300 times; maximum swelling 120.07 ? 5.28 % at 10 minutes; and patch surface pH 6. The amount of beta carotene that dispersed into the patch matrix increased up to 14.39 ? 0.52 ?g/4 cm2. The patch stuck to the rabbit palatal mucosa in 44.64?4.24 minutes and its released beta carotene across cellophane membranes by 19.7 ± 1.74 % in 8 hours. SNEDDS formulations could increase the amount of beta carotene that dispersed into the mucoadhesive matrix carotene nanoemulsion patch and released beta carotene across the cellophane membrane following the Korsmeyer-Peppas kinetics and the mechanism of Fickian release.


Cite this article:
Tris Harni Pebriani, Rurie Ratna Shantiningsih, Ronny Martien. Application Nanoemulsion of Beta Carotene in the Mucoadhesive Patch. Research J. Pharm. and Tech. 2020; 13(8):3849-3853. doi: 10.5958/0974-360X.2020.00681.2


REFERENCES:
1.    Cerqueira EMM, Meireles J, Lopes M, Rocha V, Gomes-Filho I, Trindade S, et al. Genotoxic Effects of X-rays on Keratinized Mucosa Cells During Panoramic Dental Radiography. Dento maxillo facial radiology. 2008; 37:398–403.
2.    Yadav A, Kumari R, Yadav A, Mishra JP, Srivatva S, Prabha S. Antioxidants and Its Functions in Human Body - A Review. Research in Environment and Life Sciences. 2016;1328–31.
3.    Gupta A, Dixit A, Sinha A, Mittal K. Extraction of Beta Carotene from Selected Dried and Fresh Samples of Vegetables. Asian Journal of Research in Chemistry. 2013 Feb 28;6(2):169–71.
4.    Shantiningsih RR, Suwaldi, Mudjosemedi M, Astuti I. Formulasi Sediaan Patch Gingiva Mukoadesif Betacaroten untuk Radioprotektor Radiografi Panoramik. In: Proceedings Gadjah Mada Dentistry Scientific Conference The Comprehensive Approach For Excellent Dental Practice In Universal Health Coverage Era. Yogyakarta: Gadjah Mada; 2015. p. 64–9.
5.    Shantiningsih RR, Diba SF. Efek Aplikasi Patch Gingiva Mukoadesif β-Carotene Akibat Paparan Radiografi Panoramik. Majalah Kedokteran Gigi Indonesia. 2015;1(2):186–92.
6.    Tarun P, Kumar SV, Kumar TA. Drug Delivery Via the Buccal Patch – A Novel Approach. Research Journal of Pharmaceutical Dosage Forms and Technology. 2013 Jun 28;5(3):122–30.
7.    Puratchikody A, Prasanth VV, Mathew ST, Kumar BA. Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery. Acta Pharm. 2011 Jun;61(2):157–70.
8.    Begum A, Sravya, Deepika, Manasa N, Uma, Tajeswari L, et al. Formulation and Evaluation of Fexofenadine Buccal Mucoadhesive Patches. Research Journal of Pharmacy and Technology. 2018;11(11):4892–8.
9.    Bhilegaonkar SP, Volvoikar SG, Naik AG. Formulation and Evaluation of Bilayer Gastric Mucoadhesive Patch of Captopril. Research Journal of Pharmacy and Technology. 2018 Jun 30;11(6):2444–53.
10.    Swati J, Asawaree H, Bhanudas K, Aniruddha C. Development and Evaluation of Mucoadhesive Buccal Patches of Nifedipine. Research Journal of Pharmacy and Technology. 2011;4(6):944–8.
11.    Samanthula KS, Satla SR, Bairi AG. Development, In-Vitro and Ex-Vivo Evaluation of Muco-adhesive Buccal patches of Candesartan cilexetil. Research Journal of Pharmacy and Technology. 2019 Jun 30;12(6):3038–44.
12.    Ahmed AA, Dash S. Application of Novel Nanoemulsion in Drug Targeting. Research Journal of Pharmacy and Technology. 2017 Aug 28;10(8):2809–18.
13.    Pagar KR, Darekar AB. Nanoemulsion: A new concept of Delivery System. Asian Journal of Research in Pharmaceutical Sciences. 2019 Mar 31;9(1):39–46.
14.    Alam S, Sharma P. Stability study of clobetasol propionate loaded tea tree oil nanoemulsion as per ICH guidelines. Intern Jour Contemp Microbiol. 2016;9(11):1999–2004.
15.    Namrata P, S.b G, R.b S. Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology. 2016 Dec 27;8(4):237–47.
16.    Semalty M, Semalty A, Kumar G. Formulation and Characterization of Mucoadhesive Buccal Films of Glipizide. Indian J Pharm Sci. 2008;70(1):43–8.
17.    Pendekal MS, Tegginamat P. Formulation and Evaluation of A Bioadhesive Patch for Buccal Delivery of Tizanidine. Acta Pharmaceutica Sinica B. 2012 Jun 1;2: 318–324.
18.    Saudagar RB, Vaishnav S. Pharmaceutical Nano emulsion as a Rational Carrier for Drug Delivery. Research Journal of Pharmacy and Technology. 2016 Mar 28;9(3):298–304.
19.    Hashemi M, Ramezani V, Seyedabadi M, Ranjbar AM, Jafari H, Honarvar M, et al. Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design. Adv Pharm Bull. 2017 Sep;7(3):441–50.
20.    Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Pol Pharm. 2010 Jun;67(3):217–23.
21.    Ikram M, Gilhotra N, Gilhotra RM. Formulation and Optimization of Mucoadhesive Buccal Patches of Losartan Potassium by Using Response Surface Methodology. Adv Biomed Res. 2015 Oct 29; 4:239.
22.    Zhang Y, Huo M, Zhou J, Zou A, Li W, Yao C, et al. DDSolver: An Add-In Program for Modeling and Comparison of Drug Dissolution Profiles. AAPS J. 2010 Apr 6;12(3):263–71. 

Recomonded Articles:

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Author(s): Mohamed Rizwan I, Damodharan N

DOI: 10.5958/0974-360X.2020.00247.4         Access: Closed Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): Bayu Eko Prasetyo, Karsono, Sakro Mega Maruhawa, Lia Laila

DOI: 10.5958/0974-360X.2018.00707.2         Access: Open Access Read More

Author(s): Subhashis Debnath1*, Gampa Vijay Kumar2, Satayanarayana S.V.3

DOI: Not Available         Access: Open Access Read More

Author(s): Mridanga Raj Ray, Sekhar Kumar Bose, Koushik Sengupta

DOI:         Access: Open Access Read More

Author(s): P. Raghuveer, J. Vanithakamal, D. Madhuri, A. Prameela Rani

DOI: 10.5958/0974-360X.2018.00221.4         Access: Open Access Read More

Author(s): R. Santhosh Kumar, R. Sureshkumar

DOI: 10.5958/0974-360X.2020.00625.3         Access: Closed Access Read More

Author(s): Saba Maanvizhi, V. Iyyappan, P. G. Bhavishi

DOI: 10.5958/0974-360X.2020.00517.X         Access: Closed Access Read More

Author(s): Nour Mammari, Wehad Ibrahim, Mohammad Haroun

DOI: 10.5958/0974-360X.2019.00568.7         Access: Open Access Read More

Author(s): Janani SK, R. Suresh Kumar, Chenmala Karthika, Vasanthi C, Shaik Rafi Kapoor

DOI: 10.5958/0974-360X.2019.00543.2         Access: Open Access Read More

Author(s): R.B. Saudagar, Shraddha Vaishnav

DOI: 10.5958/0974-360X.2016.00055.X         Access: Open Access Read More

Author(s): Akkas Ali Ahmed, Suvakanta Dash

DOI: 10.5958/0974-360X.2017.00497.8         Access: Open Access Read More

Author(s): Vishali Mathialagan, Abimanyu Sugumaran, Damodharan Narayanaswamy

DOI: 10.5958/0974-360X.2020.00361.3         Access: Closed Access Read More

Author(s): Hemanth Kumar K., Padma Thiagarajan, Thiagarajan N.

DOI: Not Available         Access: Open Access Read More

Author(s): Uma Sankari K, Alagusundaram M, G Krishna Sahithi, C Madhu Sudhana Chetty, S Ramkanth, S Angalaparameswari, TS Mohammed Saleem

DOI: Not Available         Access: Open Access Read More

Author(s): Arun Radhakrishnan, Gowthamarajan Kuppusamy , Senthil Venkatachalam, Rohithkrishnan Vijayakumar, Nikhitha K Shanmukhan

DOI: 10.5958/0974-360X.2019.00334.2         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags