Author(s): Simanchal Dash

Email(s): dash.simanchal73@gmail.com

DOI: 10.5958/0974-360X.2020.00680.0   

Address: Dr. Simanchal Dash
Department of Chemistry, Roland Institute of Technology, Berhampur, Odisha, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 8,     Year - 2020


ABSTRACT:
The compound 2-p-anisilidienyl 3-(benzothiazolyl-2’)hydrazono-5-p-anisilidiene-4 thiazolidinone has been synthesized by taking 2-hydrazino benzothiazole as a starting material. Regrettably the compound has poorly soluble in aqueous solvent. Consequently its inclusion complex is build up by taking ß-cyclodextrin. The physical and spectral characteristics conforms formation of inclusion complex. Although different methods available for the preparation of inclusion complexes, but co-precipitation method is used here. Phase solubility diagram is constructed for selection of 1:1 stoichiometric ratio between compound and ß-cyclodextrin. The free energy of activation and thermodynamically permittivity of the compounds predicts stability of the complexes.


Cite this article:
Simanchal Dash. Studies on inclusion complexes of 2-p-anisilidienyl 3-(benzothiazolyl-2’) hydrazono-5-p-anisilidiene-4 thiazolidinone with β-cyclodextrin. Research J. Pharm. and Tech. 2020; 13(8):3843-3848. doi: 10.5958/0974-360X.2020.00680.0

Cite(Electronic):
Simanchal Dash. Studies on inclusion complexes of 2-p-anisilidienyl 3-(benzothiazolyl-2’) hydrazono-5-p-anisilidiene-4 thiazolidinone with β-cyclodextrin. Research J. Pharm. and Tech. 2020; 13(8):3843-3848. doi: 10.5958/0974-360X.2020.00680.0   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-8-53


REFERANCES:
1.    Patil ST and Bhatt PA. Synthesis and biological evaluation of some novel 2-(4-substituted phenyl)-3-(4-substituted phenyl)-5-methylthiazolidine-4-ones. International Journal of Pharmacy & Technology. 2010; 2(3):674-682.
2.    Yadav R, Srivastava SD and Srivastava SK. synthesis, antimicrobial and anti-inflammatory activities of 4-oxothiazolidines and their 5-arylidenes. Indian Journal of Chemistry. 2005; 44B:1262-1266.
3.    Desai KG and Desai KR. A facile microwave enhanced synthesis sulfur-containing 5-membered heterocycles derieved from 2- mercaptobenzothiazole over ZnCl2/DMF and antimicrobial activity evaluation. Journal of Sulfur Chemistry. 2006;27(4); 315–328.
4.    Garnaik BK and Dash S. Recent Advances and Potential Antimicrobial Activities of Thiazolidinone Derivatives: A Review. Asian Journal of Research in Chemistry. 2014;7(4):01-12.
5.    Shih MH and Ying KF, Synthesis and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. Bioorganic Medicinal Chemistry. 2004; 12:4633-4643.
6.    Balzarini J, Orzeszko B, Maurin JK and Orzeszko A. Synthesis and anti-HIV studies of 2-adamantylsubstituted thiazolidin-4-ones. European Journal of Medicinal Chemistry. 2007; 42:993-1003.
7.    Diurno MV, Mazzoni O, Piscopo E, Calignano A, nGiordano F and Bolognesell A. Synthesis and Antihistaminic Activity of Some Thiazolidin-4-ones. Journal of Medicinal Chemistry. 1992; 35: 2910-2912.
8.    Malawska B. New anticonvulsant agents.  Current Topics in Medicinal Chem. 2005; 5: 69-85.
9.    Parmar SS, Dwivedi C, Chaudhari A and Gupta TK. Substituted thiazolidinones and their selective inhibition of nicotinamide dependant oxidations. Journal of Medicinal Chemistry. 1972; 15:99-104.
10.    Ottana R, Maccari R, Barreca ML, Bruno G, Rotondo A and Rossi A. 5-Arylidene-2-imino4thiazolidinones: Design and synthesis of novel anti-inflammatory agents. Bioorganic Medicinal Chemistry.  2005; 13: 4243-4252.
11.    Kumar A, Rajput CS and Bhati SK. Synthesis of 3-[4 '-(pchlorophenyl)- thiazol-2 '-yl]-2-[(substituted azetidinone/ thiazolidinone)- aminomethyl]-6-bromoquinazolin-4-ones as anti-inflammatory agent. Bioorganic Medicinal Chemistry. 2007; 15: 3089–3096.
12.    Vazzana I, Terranova E, Mattioli F and Sparatore F. Aromatic Schiff bases and 2,3 disubstituted-1,3-thiazolidin- 4-one derivatives as anti-inflammatory agents. Arkivoc. 2004;83 (v):364-374.
13.    Rajendra PY, Lakshmana RA, Prasoona L, Murali K and Rav KP. Synthesis and characterization of 1-formyl-3-phenyl-5-uryl- 2-pyrazolines. Bioorganic Medicinal Chemistry letter.15;2005;5030-5034.
14.    Ozdemir Z Kandilici HB, Gumusel B, Calis U and Bilgin AA. Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives. European Journal of  Medicinal Chemistry.  2007; 42:373-379.
15.    Li S and Purdy WC. Cyclodextrins and their application in analytical chemistry. Chemical Review. 1992; 92:1457-1470.
16.    Garnaik BK, Mishra N, Sen M and Nayak A, Journal of Indian Chemical  society. 1990;67: 407-408.
17.    Higuchi T and Connors K. Phase solubility technique. Advanced Anal Chem Instrument. 1965; 4:117-211.
18.    Garnaik BK and Dash S. Synthesis and antibacterial study of inclusion complexes of 2-(benzothiazolyl-2’)-azino-5-arylidene-4-thiazolidinone. Journal of Chemical and Pharmaceutical Research. 2015; 7(5):102-108.
19.    Garanaik BK and Dash S, Studies on inclusion complexes of 2-[4-(5’-benzylidene-4’-oxo-3’- phenyl thiazolidinyl-2’-imino)benzoyl]aminoimino-5-benzylidene-3-phenyl-4-thiazolidinone with β-cyclodextrin. Der Pharma Chemica .2015;7:64-69.
20.    Sahu R,Dash S and Garnaik BK. Thermal, Spectral, Antibacterial and Antioxidant Studies on Inclusion Complexes of 2-(Benzothiazolyl-2’)hydrazono-3-phenyl 5-arylidene- 4-Thiazolidinone derivatives with β-cyclodextrin , Research  Journal of  Pharmacy and Technology. 2016; 9(12) : 2265 -2270.
21.    Dash S, Sahu R and Garnaik BK. Studies on   Inclusion complexes of 2-(Benzothiazolyl-2’)hydrazono-3-phenyl-5-arylidene- 4- Thiazolidinone derivatives with β cyclodextrin.. Asian Journal of Chemistry. 2016;28: 2764-2768.
22.    Yuan C, Jin Z, Xu X, Zhuang H and Shen W. Preparation and stability of inclusion complexes of astaxanthin with hydroxypropyl β- cyclodextrin. Food Chemistry.2008;109:264-268.
23.    Benesi HA and Hilderband JH. A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons. Journal of  American Chemical Society. 1999; 71: 2703-2707.
24.    Szetli J. Molecular entrapment and release properties of drugs by cyclodextrins. Controlled Drug Bio-availability. Vol. 3, Willey Interscience publications, New York, 1985.
25.    Rajewski RA and Stella VJ. Pharmaceutical applications of cyclodextrins in vivo drug delivery. Journal of  Pharmaceutical Science.  1996; 85: 1142-1169.
26.    Stalin T, Vasantharani P, Shanti B, Sekhar A and Rajendiran N. Inclusion Complexes of trihydroxybenzene with α- and β- cyclodextrin. Indian Journal of Chemistry   Sec A.  2006; 45: 1113-1120.
27.   Patil JS, Kadam DV, Marapur SC and Kamalapur MV. Inclusion complex system: A novel technique to improve the solubility and bioavailability of poorly soluble drug: A review. International Journal of Pharmaceutical science Review and Research. 2010;2: 29-34. 

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available