Author(s):
Merina Abraham, Shajan Abraham, Feba Jose, Haritha H Pillai, Anu Abraham, Elessy Abraham, Dibyalochan Mohanty
Email(s):
cksahoophd2013@gmail.com
DOI:
10.5958/0974-360X.2020.00679.4 
Address:
Merina Abraham1, Shajan Abraham2, Feba Jose3, Haritha H Pillai4, Anu Abraham5, Elessy Abraham6, Dibyalochan Mohanty7
1PG Scholar, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
2Professor, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
3PG Scholar, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
4PG Scholar, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
5Assistant Professor, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
6Professor, Department of Pharmacology, Nazareth College of Pharmacy, Othera P.O Thiruvalla.
7Associate Professor, Department of Pharmaceutics, Anurag Group of Institutions, Hyderabad.
*Corresponding Author
Published In:
Volume - 13,
Issue - 8,
Year - 2020
ABSTRACT:
The aim of present work is to formulate and evaluate Anagliptin buccal patch by solvent casting method. Buccal patch has wide importance and it overcomes the limitations of current routes of administration, provides rapid onset of action by releasing drug directly to systemic circulation through oral mucosa by mucoadhesion. The formulated buccal patches were evaluated for various parameters like film thickness, surface pH, folding endurance, weight variation, % moisture loss, ex vivo permeation study, tensile strength, % elongation, drug content uniformity, ex vivo residence time and in vitro dissolution studies. To improve the bioavailability of the drug, buccal patch can be formulated using combination of polymers like HPMC E15, Ethyl cellulose, PVPK90, Glycerine, Methanol, Citric acid, Tween80, Menthol. It may be concluded that the films with HPMC-E15 and Ethyl cellulose (F3) show a convenient residence time and promising drug release, thus seems to be a potential candidate for the development of buccal film for effective therapeutic use. The ex vivo permeation study of the optimized formulation showed a permeation of 86.30 % within 8hr which indicate that it would provide an immediate relief due to its faster absorption in oral cavity and is a better alternative to conventional dosage forms. The in vitro drug release of optimized formulation showed drug release of 97.49%. The kinetic data analysis revealed that the formulated films best fit to Higuchi model and follows first order release kinetics. The mechanism of drug release from the film followed non- fickian diffusion.
Cite this article:
Merina Abraham, Shajan Abraham, Feba Jose, Haritha H Pillai, Anu Abraham, Elessy Abraham, Dibyalochan Mohanty. Design and In-Vitro Evaluation of Anagliptin buccal patch. Research J. Pharm. and Tech. 2020; 13(8):3837-3842. doi: 10.5958/0974-360X.2020.00679.4
Cite(Electronic):
Merina Abraham, Shajan Abraham, Feba Jose, Haritha H Pillai, Anu Abraham, Elessy Abraham, Dibyalochan Mohanty. Design and In-Vitro Evaluation of Anagliptin buccal patch. Research J. Pharm. and Tech. 2020; 13(8):3837-3842. doi: 10.5958/0974-360X.2020.00679.4 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-8-52
REFERENCES:
1. Bobade N N, Atram S C, Wankhade V P. A review on buccal drug delivery system. Int J Pharm and Pharma Sci. 2013;3(1):35-40.
2. Parmar H G, Jain J J, Patel T K, Patel V M. Buccal patch: A technical note. Int J Pharma Sci Rev Res. 2010;4(3):178-82.
3. Surender V, Ashima, Renu S. Buccal patches: Radical approach in transmucosal drug delivery. Indo Amer J Pharma Res. 2016;6(4):5181-92.
4. Jyotsana M, Sagar B, Mahesh D. Mucosal drug delivery system. Int J Res Ayurveda Pharm. 2010;1(1):63-70.
5. Shojaei A H, Chang R K, Guo X. Systemic drug delivery via buccal mucosal route. Pharmaceutical Technology. 2001:70-81.
6. Namita P, Kakar S, Singh R. A review on buccal patches. InnoriginalInt J Sci. 2016;3(5):4-8.
7. Sangeetha S, Venkatesh D N, Krishan P N. Mucosa as a route for systemic drug delivery. Res J Pharma Bio Chem Sci. 2010; 1(3): 178-187.
8. Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of Atenolol. AAPS Pharm Sci Tech. 2010;11(3):1038-44.
9. Adhikari SNR, Panda S. Buccal patches of Atenolol formulated using fenugreek (Trigonellafoenum-graecum L.) seed mucilage. Polim Med. 2017; 47(1):5-11.
10. Govindasamy P, Kesavan BR, Narasimha JK. Formulation of unidirectional release buccal patches of Carbamazepine and study of permeation through porcine buccal mucosa. Asian Pac J Trop Biomed. 2013;3(12):995-1002.
11. Srivastava AK, Wadhwa S, Ridhurkar D, Mishra B. Oral sustained delivery of Atenolol from floating matrix tablets- formulation and in vitro evaluation. Drug Dev Ind Pharm. 2005;31(4):367-74
12. Gupta SP, Jain SK. Development of matrix-membrane transdermal drug delivery system for Atenolol. Drug Deliv. 2004;11(5):281-6.
13. Govindasamy P, Kesavan BR, Narasimha JK. Formulation of unidirectional release buccal patches of carbamazepine and study of permeation through porcine buccal mucosa. Asian Pac J Trop Biomed. 2013; 3(12):995-1002.
14. Palem CR, Gannu R, Doodipala N, Yamsani VV, Yamsani MR. Transmucosal delivery of Domperidone from bilayered buccal patches: in vitro, ex vivo and in vivo characterization. Arch Pharm Res. 2011;34(10):1701-10.
15. Baviskar DT, Parik VB, Gupta HN, Maniyar AH, Jain DK. Design and evaluation of patches for transdermal delivery of Losartan potassium. PDA J Pharm Sci Technol. 2012;66(2):126-35.
16. Patel VM, Prajapati BG, Patel JK, Patel MM. Physicochemical characterization and evaluation of buccal adhesive patches containing Propranolol hydrochloride. Curr Drug Deliv. 2006; 3(3): 325-31.