Author(s): Ramavath Mohanbabu Naik, Syed Ahmed, S. Vijay Kumar, K. Radhika, K. Vinod Kumar

Email(s): mohanbabu623@gmail.com

DOI: 10.5958/0974-360X.2020.00668.X   

Address: Ramavath Mohanbabu Naik1, Syed Ahmed2, S. Vijay Kumar3, K. Radhika4, Dr. K. Vinod Kumar5
1Asst Professor, Department of Pharmaceutical Analysis and Quality Assurance, Gland Institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334.
2Asst Professor, Department of Pharmaceutics, Gland Institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334.
3Asst Professor, Department of Pharmacognosy, Vishnu Institute of Pharmaceutical Education and Research, Narsapur (Mandal), Medak (District), Telangana-502334.
4Asst Professor, Department of Pharmacology, Gland institute of Pharmaceutical Science, Kothapet (V), Near Narsapur, Medak (District), Telangana-502334.
5Associate Professor, Department of Pharmaceutical Analysis and Quality Assurance, Raghavendra Institute of Pharmaceutical Education and Research, Krishnam Reddy Pally (V), Ananthapuramu- 515721, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 8,     Year - 2020


ABSTRACT:
A simple, precise, accurate and economical UV-Spectrophotometric method has been developed and validated for the simultaneous estimation of Hydrocortisone and Iodoquinol in combined pharmaceutical dosage form using simultaneous equation method. Hydrocortisone has absorbance maxima at 245nm and Iodoquinol has absorbance maxima at 250nm in Methanol. The drugs obeyed beer’s law in the concentration range of 10-60µg/ml for Hydrocortisone and 5-30µg/ml for Iodoquinol. The correlation coefficient of Hydrocortisone and Iodoquinol was found to be 0.999 and 0.999 respectively. The method was statistically validated as per the ICH guidelines. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The developed method was simple, precise, accurate, reproducible and economical which can be efficiently and easily applied to pharmaceutical dosage form.


Cite this article:
Ramavath Mohanbabu Naik, Syed Ahmed, S. Vijay Kumar, K. Radhika, K. Vinod Kumar. Development and Validation of UV-Spectroscopic methods for simultaneous Estimation of Hydrocortisone and Iodoquinol in Tablet Dosage Forms. Research J. Pharm. and Tech. 2020; 13(8):3777-3780. doi: 10.5958/0974-360X.2020.00668.X

Cite(Electronic):
Ramavath Mohanbabu Naik, Syed Ahmed, S. Vijay Kumar, K. Radhika, K. Vinod Kumar. Development and Validation of UV-Spectroscopic methods for simultaneous Estimation of Hydrocortisone and Iodoquinol in Tablet Dosage Forms. Research J. Pharm. and Tech. 2020; 13(8):3777-3780. doi: 10.5958/0974-360X.2020.00668.X   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-8-41


REFERENCE:
1.    Ramavath Mohanbabu Naik, Syed Ahmed , S. Vijaykumar, Dr. D. Ramakrishna, K. Venkatalakshmi. Simultaneous Estimation of hydrocortisone and ketoconazole in tablet dosage form by UV-Spectroscopy. Journal of Pharma Research. 2019;8(5):323-326.N: 2319-5622.
2.    Ramavath Mohanbabu Naik, Swapna Gumpula and Prajakta Shamsundar Mhaskar. Simultaneous Estimation of hydrocortisone and ketoconazole in pharmaceutical dosage form by RP-HPLC method. International Journal of Pharmaceutical Sciences and Research. 2018; 9(11): 4805-4811.
3.    Sunil Kumar, R.K. Nanda, Pritam Kuttepali, S.K. Sharma. Development and Validation of RP-HPLC Method for Estimation of Hamycin and Ketoconazole in Pharmaceutical Cream. Pharm Analysis and Quality Assurance. 2014; 5(1): 263-268.
4.   Ramavath Mohanbabu Naik, Syed Ahmed, G. Naveen Kumar Reddy. RP-HPLC Method Development and Validation for Simultaneous Estimation of Hydrocortisone and Acyclovir in Pharmaceutical dosage forms. American Journal of Pharmacy and Health Research. 2018; 6(6):5-18.

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