Sahithi Kattamuri, Aravindhanathan Venkatesan, Sumalatda Devi Balamurugan, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh
Sahithi Kattamuri1, Aravindhanathan Venkatesan1, Sumalatda Devi Balamurugan1, Arun Radhakrishnan1, Gowthamarajan Kuppusamy1*, Sachin Kumar Singh2
1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India.
2School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.
Volume - 13,
Issue - 8,
Year - 2020
Capsule is one of the most commonly used dosage form for drugs which are intended to take orally. Capsules are in use over 160 years. Gelatin is the major polymer used for capsule preparation which is natural polymer obtained from animal source i.e. skin and bones of pigs and cows. The usage of gelatin in capsule making is decreased due to many reasons like source of gelatin is from animals which causes mad cow disease and cross linking of gelatin with drugs which decreases the efficiency of drug. To avoid problems with gelatin, the polymers from plants like Sodium alginate is obtained from sea weed, purely as Alginic acid and then converted into sodium alginate by chemical treatment was used in the experiment to make capsules which also have enteric property to avoid dissolution of capsules in acidic pH. Carrageenan and tragacanth was used as thickening agents to improve the texture of Capsule.
Cite this article:
Sahithi Kattamuri, Aravindhanathan Venkatesan, Sumalatda Devi Balamurugan, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh. Preparation and Evaluation of Enteric Capsules. Research J. Pharm. and Tech. 2020; 13(8):3603-3609. doi: 10.5958/0974-360X.2020.00637.X
Sahithi Kattamuri, Aravindhanathan Venkatesan, Sumalatda Devi Balamurugan, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh. Preparation and Evaluation of Enteric Capsules. Research J. Pharm. and Tech. 2020; 13(8):3603-3609. doi: 10.5958/0974-360X.2020.00637.X Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-8-10
1. Choosing the Right Capsule Part 3 – Enteric Capsules. Capsuline. April 21, 2017 Available from: URL: https://capsuline.com/blogs/ capsuline-blog/choosing-the-right-capsule-part-3-enteric-capsules.
2. Shelly S. Empty Capsules Market worth $2.79 Billion by 2023. 2018. Available from: URL: http://www.marketsandmarkets.com/ Press Releases/empty-capsules.asp.
3. Podczeck F, Jones BE. Pharmaceutical capsules. Pharmaceutical Press; 2004; 4:24
4. Singh DH, Roychowdhury S, Verma P., Bhandari V. A review on recent advances of enteric coating. IOSR Journal of Pharmacy. 2012; 2(6): 05-11.
5. Reddy G, Muthukumaran M, Krishnamoorthy B. Soft gelatin capsules-present and future prospective as a pharmaceutical dosage forms—a review. Int J Adv Pharm Gen Res.2013; 1(1):20-9.
6. Ku MS, Li W, Dulin W, Donahue F, Cade D, Benameur H, Hutchison K. Performance qualification of a new hypromellose capsule: Part I. Comparative evaluation of physical, mechanical and processability quality attributes of VCaps Plus®, Quali-V® and gelatin capsules. Int. J. Pharm. 2010; 30-41.
7. Kraan, S. Algal Polysaccharides, Novel Applications and Outlook. Carbohydrates - Comprehensive Studies on Glycobiology and Glycotechnology. 2012
8. Abdul Khalil HPS, Tye YY, Saurabh CK, Leh CP, Lai TK, Chong EWN, et al. Biodegradable polymer films from seaweed polysaccharides: A review on cellulose as a reinforcement material. express Polymer Letters . 2017; 11(4): 244–265.
9. Baweja P, Kumar S, Sahoo D, Levine I. Biology of Seaweeds. Seaweed in Health and Disease Prevention. 2016: 41–106.
10. Farmeh Helper. Quality Approved Tragacanth Gum in Center City. Trade India. Available from: URL: https:// www.tradeindia.com/fp5629005/Quality-Approved-Tragacanth-Gum.html .
11. Al-Tabakha MM. HPMC capsules: current status and future prospects IJPPS. 2010; 13(3):428-42.
12. He H, Ye J, Zhang X, Huang Y, Li X, Xiao M. κ-Carrageenan/locust bean gum as hard capsule gelling agents. Carbohydrate Polymers. 2017; 175: 417-24.
13. Zhang Y, Zhao Q, Wang H, Jiang X, Cha R. Preparation of green and gelatin-free nanocrystalline cellulose capsules. Carbohydr. Polym. 2017; 358-63.
14. Oladzadabbasabadi N, Ebadi S, Nafchi AM, Karim AA, Kiahosseini SR. Functional properties of dually modified sago starch/κ-carrageenan films: An alternative to gelatin in pharmaceutical capsules. Carbohydr. polym. 2017; 43-551.
15. Zhang N, Liu H, Yu L, Liu X, Zhang L, Chen L, Shanks R. Developing gelatin–starch blends for use as capsule materials. Carbohydrpolym. 2013; 455-61.
16. Lenna A. (2017) Thickness Measuring Tools. Sciencing Available from: URL: https://sciencing.com/thickness-measuring-tools-6750027.html.
17. Bennour, S., and Louzri, F. (2014). Study of Swelling Properties and Thermal Behavior of Poly(N,N-Dimethylacrylamide-co-Maleic Acid) Based Hydrogels. Advances in Chemistry, 2014, 1–10.
18. Augsburger LL. Hard and Soft Shell Capsules, in Banker GS and Rhodes CT (eds), Modern Pharmaceutics. Marcel Dekker, Inc, New York, 2002; 121.
19. Chiwele I, Jones BE and Podczeck F. The shell dissolution of various empty hard capsules. Chem Pharm Bull. 2000; 48:951- 956.
20. Alberto T, María del CNS. (2012). Solution Properties of κ-Carrageenan and Its Interaction with Other Polysaccharides in Aqueous Media, Rheology, Dr. Juan De Vicente (Ed.), ISBN: 978- 953-51-0187-1, In Tech, Available from: http:// www.intechopen.com/ books/rheology/solution-properties-of-kcarrageenan-and-its-interaction-with-other-polysaccharides-in-aqueous-media