Author(s): Harshad S. Kapare, Sathiyanarayanan L.

Email(s): harshad.kapare@dypvp.edu.in

DOI: 10.5958/0974-360X.2020.00627.7   

Address: Harshad S. Kapare1*, Sathiyanarayanan L.2
1Dr. D Y Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India.
2Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University, Erandwane, Pune- 411038 India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
Propolis is resinous waxy natural product derived from honey bee combs. The aim of this study was to review the nutritional and therapeutic potential of propolis so as to provide basic data required for further detailed investigation of propolis. Chemical analysis data reported showed presence of phenolic compounds, esters, flavonoids, terpenes, beta-steroids, aromatic aldehydes and alcohols, sesquiterpenes, and stilbene terpenes and more than 300 chemical compounds. Pharmacological studies revealed that different extracts of propolis is possess antiviral, anti inflammatory, antioxidant, antibacterial, antifungal and anti-ulcer traditionally. It is also used as nutritional and functional food ingredient. Propolis possesses tremendous nutritional and therapeutic potential and it is worldwide reported in various natural or traditional systems. In this study, propolis characteristic, nutritional value, therapeutic potential and various issues reported in formulation development for improvement of physicochemical and biopharmaceutical properties of propolis has been reviewed.


Cite this article:
Harshad S. Kapare, Sathiyanarayanan L. Nutritional and Therapeutic potential of Propolis: A Review. Research J. Pharm. and Tech. 2020; 13(7): 3545-3549. doi: 10.5958/0974-360X.2020.00627.7


REFERENCES:
1. Baerheim SA, Scheffer JJ. Natural products in therapy Prospects, goals and means in modern research. Pharm Weekbl Sci 1982; 4(4): 93-103.
2. Viuda-Martos M, Ruiz-Navajas Y, Fernandez-Lopez J, Perez-Alvarez JA. Functional Properties of Honey, Propolis, and Royal Jelly: J Food Sci.2008; 73(9): R117-24
3. Nagai T, Nagashima T, Myoda T, Inoue R. Preparation and functional properties of extracts from bee bread. Nahrung. 2004; 48(3): 226-9.
4. Hilliam M. Functional foods. The World of Food Ingredients 1999; 3(4) 46–49.
5. Hilliam M. Functional food– How big is the market? The World of Food Ingredients 2000; (12): 50–52
6. Hjaltason B, Haraldsson GG. Use of fish oils and marine PUFA concentrates Woodhead publishing series in food science, technology and nutrition 2006; 587-602
7. Jacobsen C, Let MB. Using polyunsaturated fatty acids (PUFAs) as functional ingredients. Woodhead publishing series in food science, technology and nutrition 2006; 428-453
8. Krell R. Value-added products from beekeeping” FAO agricultural services bulletin no. 124, Food and Agriculture Organization of the United Nations Rome; 1996: 153-186.
9. Bogdanov S. Propolis: Composition, Health, Medicine: A Review. Bee Product Science 2017: 1-44
10. William LC, Morse RA. Beeswax; production, harvesting, processing and products” Wicwas Press, Ithaca, New York, U.S.A. 1984 
11. Lu LC, Chen YW, Chou CC. Antibacterial activity of propolis against Staphylococcus aureus. Int J Food Microbiol. 2005; 102(2):213-20.
12. Yang HY, Ho WL, Chang CM, Chou CM. Antibacterial Activity of Propolis Ethanol Extract Against Streptococcus mutans as Influenced by Concentration, Temperature, pH and Cell Age. Journal of Food and Drug Analysis 2007; 15(1) 75-81.
13. Nada H., Naher HS, Charrakh AHA. In vitro antibacterial and antifungal activity of Iraqi propolis. Journal of Medicinal Plants Research 2011; 5(20): 5058-5066
14. Li-Chang Lu , Yue-Wen Chen, Cheng-Chun Chou. Antibacterial and DPPH Free Radical-scavenging Activities of the Ethanol Extract of Propolis Collected in Taiwan. Journal of Food and Drug Analysis2003; 11(4): 277-282
15. Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S. Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol. 1999; 64(3): 235-40.
16. Pontin K, Da Silva Filho AA, Santos FF, Silva ML, Cunha WR, Nanayakkara NP, Bastos JK, de Albuquerque S. In vitro and in vivo antileishmanial activities of a Brazilian green propolis extract. Parasitol Res. 2008; 103(3): 487-92.
17. Muli EM, Maingi JM, Macharia J. Antimicrobial Properties of Propolis and Honey from the Kenyan Stingless bee. APIACTA 2008; 43: 49 – 61.
18. Amoros M, Simoes CM, Girre L, Sauvager F, Cormier M. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod. 1992; 55(12):1732-40.
19. Hegazi AG, Abd E, Hady FK, Abd Allah FA. Chemical composition and antimicrobial activity of European propolis. Z Naturforsch C. 2000; 55(1-2):70-5.
20. Nieva Moreno MI, Zampini IC, Ordonez RM, Jaime GS, Vattuone MA, Isla MI. Evaluation of the cytotoxicity, genotoxicity, mutagenicity, and antimutagenicity of propolis from Tucuman Argentina. J Agric Food Chem. 2005; 53(23): 8957-62.
21. Hee YC. In vitro Evaluation of the Antifungal Activity of Propolis Extract on Cryptococcus neoformans and Candida albicans. Mycobiology 2002; 30(2): 93-95.
22. Hyun K, Pedro LR, Jaime AC, Yong KP,  . Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity. Antimicrob Agents Chemother 2002; 46(5): 1302–1309.
23. Sawicka D, Car H, Halina M, Borawska HM, Niklinski J. The anticancer activity of propolis. Folia histochemica et Cytobiologica 2012; 50: 25–37.
24. Choudhari MK, Haghniaz R, Rajwade JM, Paknikar KM. Anticancer activity of Indian stingless bee propolis: an in vitro study. Evidence-Based Complementary and Alternative Medicine 2013; Article ID 928280: 1-10.
25. Watanabe MAE, Amarante MK, Conti BJ, Sforcin JM. Cytotoxic constituents of propolis inducing anticancer effects: a review. Journal of Pharmacy and Pharmacology 2011; 63: 1378–1386.
26. Coral O, Matko K, Jing W, Enrica M, Krystyna F, Owen A O’Connor. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action. J Cancer Sci Ther. 2013, 5(10): 334–342.
27. Thirugnanasampandan R., Raveendran SB, Jayakumar R. Analysis of chemical composition and bioactive property evaluation of Indian propolis. Asian Pac. J Trop. Biomed 2012; 2(8): 651-654.
28. Yuan J, Lu Y, Abula S, Hu Y, Liu J, Fan Y, Zhao X, Wang D, Liu X, Liu C. Optimization on preparation condition of propolis flavonoids liposomes by response surface methodology and research of its immunoenhancement activity. Evidence-based complementary and alternative medicine 2013; Article ID 505703: 1-8.
29. Roy N, Mondal S, Laskar RA, Basu S, Mandal D, Begum NA. Biogenic synthesis of Au and Ag nanoparticles by Indian propolis and its constituents. Colloids Surf B Biointerfaces 2010; 76(1):317-25
30. Derman S. Caffeic Acid Phenethyl Ester Loaded PLGA Nanoparticles: Effect of Various Process Parameters on Reaction Yield, Encapsulation Efficiency, and Particle Size. Hindawi Publishing Corporation, Journal of Nanomaterials 2015; Article ID 341848: 1-12.
31. Kothai S, Jayanthi B. Anti cancer activity of silver nano particles bio-synthesized using stingless bee propolis (Tetragonula iridipennis) of Tamilnadu. Asian Journal of Biomedical and Pharmaceutical Sciences 2014; 04 (40): 30-37.
32. Kothai S. Jayanthi B. A study on Propolis of Stingless Bees reared from the most Commercial Hub of Chennai, Tamilnadu, India. Int. Res. J. Environment Sci 2015; 4(7): 39-47.
33. Lee HY, Jeong YI, Kim EJ, Lee KD, Choi SH, Kim YJ, Kim DH, Choi KC. Preparation of caffeic acid phenethyl ester-incorporated nanoparticles and their biological activity. J Pharm Sci. 2015; 104(1): 144–154.
34. Bharti U, Kumar NR, Chaudhary D. Modulatory Prospective of Bee Pollen against Oxidative Stress Induced by Drugs: A Review. Research J. Pharm. and Tech 2018; 11(12): 5648-5652.
35. Kapare HS, Lohidasan S, Arulmozhi S, Mahadik KR. Standardization, chemical profiling, in vitro cytotoxic effects, in vivo anti-carcinogenic potential and biosafety profile of Indian propolis. Journal of Ayurveda and integrative medicine 2019; 10(2): 81-87
36. Kapare HS, Lohidasan S, Arulmozhi S, Mahadik KR. Design and Development of Indian Propolis Loaded Poly (ε -Caprolactone) Nanoparticles for Improved Anticancer Efficacy International Journal of Pharmaceutical Research. 2017; 9 (3), 73-80

Recomonded Articles:

Author(s): Amina Mehrin Bano, Vishnupriya. V, Gayathri. R

DOI: 10.5958/0974-360X.2016.00171.2         Access: Open Access Read More

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Kousalya M., Geetha P., Jesuraja A., Vinoth Kumar M

DOI: 10.5958/0974-360X.2017.00014.2         Access: Open Access Read More

Author(s): Ahmed Hilal Sheriff, Preetham Prasad Nittla

DOI: 10.5958/0974-360X.2019.00968.5         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Sandesh More, Javed Mirza, Nanasaheb Kale, Mayur Gandhi, Rakesh Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Vishal Vilas Shah, Nutan Dhanpal Shah, Prasad Vasantrao Patrekar

DOI: Not Available         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Vikram Kumar Sahu, Amit Mishra, Nitin Sharma, Pratap Kumar Sahu, Shubhini A. Saraf

DOI: 10.5958/0974-360X.2017.00048.8         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags