ABSTRACT:
More than 60% of the discovered drugs have the problem of low aqueous solubility which leads to their poor dissolution and reduced bioavailability. There are many techniques to overcome this problem like cyclodextrin complexation, salt formation, particle size reduction, solid dispersion, lipid based formulations, etc. Self-nano emulsifying drug delivery system (SNEDDS) is one of the techniques which is gaining more attention for improving the solubility of the lipophilic drug. SNEDDS is an isotropic mixture of oil, surfactant, and co-surfactant which forms oil in water (o/w) nanoemulsion with slight agitation. Oil is selected based on their solubility capacity and both surfactant and co-surfactant is selected based on their emulsifying ability. To prevent the precipitation of the drug and to reduce the dosing frequency, suitable precipitation inhibitors can be used (maintains supersaturation state and blocks the formation and growth of the crystals). By introducing precipitation inhibitors into the formulation, the surfactant concentration can be minimized (reduce GI side effects). The liquid formulation is converted into solid dosage form (by the use of adsorbents) to improve the stability. Various solidification techniques can be used for the conversion of solid dosage form. Hence, Solid Supersaturable SNEDDS (Solid S-SNEDDS) is an effective method for the oral delivery of poorly water-soluble drug, in order to improve its bioavailability.