Author(s): Praveen. K, Balamurugan. K


DOI: 10.5958/0974-360X.2020.00624.1   

Address: Praveen. K1*, Balamurugan. K2
1M.Pharm., IInd Year, Department of Pharmacy, FEAT, Annamalai University, Annamali Nagar, Chidambaram - 608002, Tamilnadu, India.
2Associate Professor, Department of Pharmacy, FEAT, Annamalai University, Annamali Nagar, Chidambaram - 608 002, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020

Efficient targeted drug transport approaches have been a dream for several decades. Nanosponge’s drug transport system has emerged as one of the promising discipline in novel drug delivery technology. Recently the nanosponge drug delivery system has been big step to resolve the certain biopharmaceutical problems. The nanosponge targets the drug into the systemic circulation in the body until they encounter the particular targeted surface, and begin the release of drug in controlled drug and predictable way. Nanosponge’s drug release systems were loaded with hydrophilic and lipophilic drug substance in a huge range drug molecule. Thus the nanosponge acts as suitable targeted carrier molecule. In the nanosponge technique the drug can be deliver in specific site, which prevent the drug, protein degradation, prolong drug release is a predictable way. Nanosponge technology is used to increasing the poor bioavailability of drug substance and the transport of drug into oral, parenteral as well as topical route. In the review article, the approaches for the preparation, evaluation and application of nanosponge were discussed.

Cite this article:
Praveen. K, Balamurugan. K. Targeted Drug Delivery through Nanosponges and its Approach. Research J. Pharm. and Tech. 2020; 13(7): 3524-3529. doi: 10.5958/0974-360X.2020.00624.1

Praveen. K, Balamurugan. K. Targeted Drug Delivery through Nanosponges and its Approach. Research J. Pharm. and Tech. 2020; 13(7): 3524-3529. doi: 10.5958/0974-360X.2020.00624.1   Available on:

1. Harth, E., Nanomedicine: Development of “Nanosponges” as superior sustain delivery systems of diverse biological cargos. Department of Chemistry, Vanderbilt University, USA, 2011.
2. Vyas, S. and R. Khar, Targeted and Controlled Drug Delivery-Novel Carrier Systems: Molecular Basis of Targeted Drug Delivery. 2012, CBS Publishers and Distributors New Delhi.
3. Szejtli, J., Cyclodextrin Technology. Vol. 1. 2013: Springer Science and Business Media.
4. Trotta, F. and R. Cavalli, Characterization and applications of new hyper-cross-linked cyclodextrins. Composite Interfaces, 2009. 16(1): p. 39-48.
5. David, F., Nanosponge drug delivery system more effective than direct injection, 2010. 2011.
6. Krishnamoorthy, K. and M. Rajappan, Nanosponges: a novel class of drug delivery system--review. Journal of Pharmacy and Pharmaceutical Sciences: a publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 2012. 15(1): p. 103-111.
7. Cavalli, R., F. Trotta, and W. Tumiatti, Cyclodextrin-based nanosponges for drug delivery. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2006. 56(1-2): p. 209-213.
8. Setijadi, E., et al., Biodegradable star polymers functionalized with β-cyclodextrin inclusion complexes. Biomacromolecules, 2009. 10(9): p. 2699-2707.
9. Aldawsari, H.M., et al., Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation. International Journal of Nanomedicine, 2015. 10: p. 893.
10. Alongi, J., et al., Role of β-cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011. 86(1): p. 127-135.
11. Leslie, Z., Benet. BCS and BDDCS. Bioavailability and Bioequivalence: Docus on Physiological Factors and Variability. Department of pharmaceutical sciences, University of California, San Francisco, USA, 2007.
12. Aritomi, H., et al., Development of Sustained-Release Formulation of Chlorpheniramine Maleate Using Powder-Coated Microsponge Prepared by Dry Impact Blending Method. Journal of Pharma Sci and Tech, 1996. 56(1): p. 49-56.
13. Rita, L., T. Amit, and G. Chandrashekhar, Current trends in β-cyclodextrin based drug delivery systems. Int. J. Res. Ayurveda Pharm, 2011. 2: p. 1520-1526.
14. Swaminathan, S., et al., Structural evidence of differential forms of nanosponges of beta-cyclodextrin and its effect on solubilization of a model drug. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2013. 76(1-2): p. 201-211.
15. Trotta, F., et al., Ultrasound-assisted synthesis of cyclodextrin-based nanosponges. 2008, Google Patents.
16. Sharma, R. and K. Pathak, Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. Pharmaceutical Development and Technology, 2011. 16(4): p. 367-376.
17. Swaminathan, S., et al., Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity. European Journal of Pharmaceutics and Biopharmaceutics, 2010. 74(2): p. 193-201.
18. Embil, K. and S. Nacht, The microsponge delivery system (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. Journal of Microencapsulation, 1996. 13(5): p. 575-588.
19. Mishra, M.K., et al., Optimization, formulation development and characterization of Eudragit RS 100 loaded microsponges and subsequent colonic delivery. Int J Drug Discov Herb Res, 2011. 1: p. 8-13.
20. Patil, T.S., et al., Nanosponges: A Novel Targeted Drug delivery for cancer treatment. International Journal for Advance Research and Development, 2017. 2(4).
21. Wolfgang, S., Sample preparation in Light Scattering from and Nanoparticle Dispersions. Springer Berlin Heidelberg GmbH and Co. Int J Pharm, 2013. 344(1-2): p. 33-43.
22. Singh, R., et al., Characterization of cyclodextrin inclusion complexes—a review. J. Pharm. Sci. Technol, 2010. 2(3): p. 171-183.
23. Swaminathan, S., et al., In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of β-cyclodextrin. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2010. 68(1-2): p. 183-191.
24. Selvamuthukumar, S., et al., Nanosponges: A novel class of drug delivery system-review. Journal of Pharmacy and Pharmaceutical Sciences, 2012. 15(1): p. 103-111.
25. Challa, R., et al., Cyclodextrins in drug delivery: an updated review. Aaps Pharmscitech, 2005. 6(2): p. E329-E357.
26. Wong, V.N., et al., Separation of peptides with polyionic nanosponges for MALDI-MS analysis. Langmuir, 2009. 25(3): p. 1459-1465.
27. Duchěne, D.e., et al., Cyclodextrins, their value in pharmaceutical technology. Drug Development and Industrial Pharmacy, 1986. 12(11-13): p. 2193-2215.
28. Davis, M.E., Z. Chen, and D.M. Shin, Nanoparticle therapeutics: an emerging treatment modality for cancer, in Nanoscience and Technology: A Collection of Reviews from Nature Journals. 2010, World Scientific. p. 239-250.
29. Melani, F., et al., New docking CFF91 parameters specific for cyclodextrin inclusion complexes. Chemical Physics Letters, 2003. 370(1-2): p. 280-292.
30. Torne, S.J., et al., Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded nanosponges. Drug Delivery, 2010. 17(6): p. 419-425.
31. Ansari, K.A., et al., Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study. Aaps Pharmscitech, 2011. 12(1): p. 279-286.
32. Rao, M., et al., Investigation of nanoporous colloidal carrier for solubility enhancement of Cefpodoxime proxetil. Journal of Pharmacy Research, 2012. 5(5): p. 2496-2499.
33. A Ansari, K., et al., Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Current Drug Delivery, 2011. 8(2): p. 194-202.
34. Yadav, G.V. And H.P. Panchory, Nanosponges : a boon to the targeted drug delivery system. Journal of Drug Delivery and Therapeutics, 2013. 3(4): p. 151-155.
35.  Boscolo, B., F. Trotta, and E. Ghibaudi, High catalytic performances of Pseudomonas fluorescens lipase adsorbed on a new type of cyclodextrin-based nanosponges. Journal of Molecular Catalysis B: Enzymatic, 2010. 62(2): p. 155-161.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available