At present, Pharmaceutical industry is focused on developing new drug delivery system which increases the therapeutic efficacy and reduces the side effects. In recent trends, the MDDS is especially fitting for pulsatile release and controlled release, as these formulations possess several advantages such as dose dumping and low risk. Because of its unique property, MDDS plays a major role in a solid dosage form. In recent, much emphasis is being laid on multi-unit dosage form, because the particle size is smaller in multi-unit dosage form which passes through the GI track easily. Continuously MDDS provide multiple chances for designing controlled release and delayed release oral formulation which helps for future pharmaceutical development.
Cite this article:
Giridharan Sivalingan, Ganesh GNK, Mithra Chandrasekaran. Multiparticulate Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(7): 3501-3507. doi: 10.5958/0974-360X.2020.00620.4
Giridharan Sivalingan, Ganesh GNK, Mithra Chandrasekaran. Multiparticulate Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(7): 3501-3507. doi: 10.5958/0974-360X.2020.00620.4 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-7-80
1. Bipin Gandhi And Jagdish Baheti. Multiparticulates Drug Delivery Systems. International Journal Of Pharmaceutical And Chemical Sciences. 2013;2(3):1620-1626.
2. NS Dey, S Majumdar, et al. Multiparticulate Drug Delivery Systems for Controlled Release. Tropical Journal of Pharmaceutical Research. 2008; 7 (3): 1067-1075.
3. V. R. Sirisha K., K. Vijaya Sri, et al. A Review Of Pellets And Pelletization Process - A Multiparticulate Drug Delivery System, International Journal of Pharmaceutical Science And Research, 2013;4(6): 2145-2158.
4. Shailesh L. Patwekar, Mahesh K Baramade, Controlled Release Approach To Novel Multiparticulate Drug Delivery System. International Journal of Pharmacy and Pharmaceutical Sciences. 2012:4
5. Anushuli, Sandhya Chaurasia. Multiparticulate Drug Delivery System, Pelletization Through Extrusion And Spheronization. International Research Journal OfPharmacy. 2013; 4(2): 6-9.
6. Harshal Gavali, Divya Nair, et al. Multiparticulate Drug Delivery System And Their Processing Techniques. World Journal of Pharmaceutical Research. 2015;4: 1949-1960.
7. Parul B. Patel and Avinash S. Dhake. Multiparticulate approach: an emerging trend in colon specific drug delivery for Chronotherapy. Journal of Applied Pharmaceutical Science. 2011; 1(5): 59-63.
8. Sumit Kumar, Kamal Jeet, et al. Recent Technological Advancements in Multiparticulate Formulations: The Smart Drug Delivery Systems. Asian Journal of Pharmaceutics. 2015;9(4): S13-S25.
9. Nrupa G. Patel, Sandipkumar A. Patel , et al. Multiple Unit Pellet System (Mups Technology) For Development Of Modified Release Fast Disintegrating Tablets. Journal of Pharmaceutical and Scientific Innovation. 2017; 6(3):50-56.
10. Motor Leela Keerthi, R. Shireesh Kiran, et al. Pharmaceutical Mini-Tablets, its Advantages, Formulation Possibilities and General Evaluation Aspects. International Journal of Pharmaceutical Sciences Review and Research. 2014;28(1):214-221.
11. Swapnil Waghmare, R.V. Kshirsagar, et al. Review On Multiparticulate System. International Journal of Pharmacy. 2016; 6(3): 91-96.
12. Rajesh Gandhi, Chaman Lal Kaul, et al. Extrusion and spheronization in the development of Oral Controlled-release Dosage Forms. 1999;2
13. Hicks D C, Freese H I. Pharmaceutical Pelletization Technology. 2007:71-100.
14. J. Vertomrnen and R. Kinget, The Influence of Five Selected Processing and Formulation Variables on the Particle Size, Particle Size Distribution, and Friability of Pellets Produced in a Rotary Processor. Drug Development and Industrial Pharmacy. 1997;23(1):39-46.
15. Nantharat Pearnchob, Roland Bodmeier. Coating of pellets with micronized ethyl cellulose particles by a dry powder coating technique. International Journal of Pharmaceutics. 2003;268:1–11.
16. Harun Ar Rashid, J. Heina ÈmaÈki, et al. In¯uence of the centrifugal granulating process on the properties of layered pellets. European Journal of Pharmaceutics and Biopharmaceutics. 2001;51: 227-234.
17. F.J. Lbpez-Rodriguez, J.J. Torrado, et al. Compression Behavior Of Acetylsalicylic Acid Pellets. Drug Development And Industrial Pharmacy. 1993;19(12):1369-1377.
18. J.J. Sousa , A. Sousa , et al. Factors inﬂuencing the physical characteristics of pellets obtained by extrusion-spheronization. International Journal of Pharmaceutics. 2002; 232:91–106.
19. Åsa Tunón, Elisabet Börjesson, et al. Drug release from reservoir pellets compacted with some excipients of different physical properties. European Journal of Pharmaceutical Sciences. 2003;20:469–479.
20. Rajesh Agrawal and Yadav Naveen. Pharmaceutical Processing-A Review on Wet Granulation Technology. International Journal of Pharmaceutical Frontier Research. 2011; 1(1):65-83.
21. Joanne Heafield, Stewart T. Leslie, et al. all of Cambridge, United Kingdom, SPHERODS, 1-6.
22. Rouge N, Cole E T, et al. Screening of potentially floating excipients for minitablets. S T P Pharm Sci. 1997;7: 386-392.
23. P. Colombo, U. Conte, et al. Compressed Polymeric Mini-Matrices For Drug Release. Journal of Controlled Release. 1985;1:283-289.
24. J. Sujja-areevath , D.L. Munday, et al. Relationship between swelling, erosion and drug release in hydrophillic natural gum mini-matrix formulations. European Journal of Pharmaceutical Sciences. 1998;6: 207–217.
25. Paolo Colombo, Ruggero Bettini, et al. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. 2000;3:198-204.
26. Søren Kiil, Kim Dam-Johans. controlled drug delivery from swellable hydroxy propyl methyl cellulose matrices: model-based analysis of observed radial front movements. Journal of Controlled Release. 2003; 90 :1-21.
27. Ronald S, Harland Andrea, et al. Peppas, Drug/Polymer Matrix Swelling and Dissolution. Pharm Res, 1998; 5: 37.
28. Elpiniki Papadimitriou, Graham Buckton, et al. Probing the mechanisms of swelling of hydroxy propyl methyl cellulose matrices. International Journal of Pharmaceutics. 1993;98:51-62.
29. Fell J T, Newton J M. The tensile strength of lactose tablets. J Pharm Pharmacol. 1968;20: 205-212.