Author(s): Yamana Srikanth, T Tamilanban, V Chitra


DOI: 10.5958/0974-360X.2020.00613.7   

Address: Yamana Srikanth*, T Tamilanban, V Chitra
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020

Alzheimer’s disease is associated with the leading cause of dementia worldwide. Most of the peoples suffering from dementia. Itis an age-related neurodegenerative disorder characterized by memory loss and personality change, cognition function. Various studies carry to find out the therapeutic level for an AD, so still, no proper treatment is not available, but systemic medication is useful for the memory and other dementia-related problems. During Ancient time several medicinal plants and herbal preparations are traditionally used for memory and cognition enhancer. Most of the ayurvedic medicinal plants are used to slow down the brain age and promote memory include Ashwagandha, Turmeric, Brahmi, Shankapushpi, Gotu kola, Guggulu etc. are related utilization of ayurvedic medicinal plants are mostly dependent upon traditional uses and signal transduction processes like efficacy and safety. Finally, this review will concentrate on late research finding concerning the effectiveness of different plants according to their antioxidant, anti-inflammatory, neuroprotective and enhancing properties in Alzheimer’s disease.

Cite this article:
Yamana Srikanth, T Tamilanban, V Chitra. Medicinal plants Targeting Alzheimer’s disease - A Review. Research J. Pharm. and Tech. 2020; 13(7): 3454-3458. doi: 10.5958/0974-360X.2020.00613.7

Yamana Srikanth, T Tamilanban, V Chitra. Medicinal plants Targeting Alzheimer’s disease - A Review. Research J. Pharm. and Tech. 2020; 13(7): 3454-3458. doi: 10.5958/0974-360X.2020.00613.7   Available on:

1. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011) Alzheimer’s disease. Lancet 377:1019-1031.
2. Squire R (1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol Rev 99:195-231.
3. Montejo P, Montenegro M, Fernandez M, Maestu F (2011) Subjective memory complaints in the elderly: Prevalence and influence of temporal orientation, depression and quality of life in a population-based study in the city of Madrid. Aging Ment Health 15:85-96.
4. Demetrius LA, Magistretti PJ, Pellerin L. Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect. Front Physiol. 2015; 5:522.
5. Rea R, Carotenuto A, Fasanaro AM, Traini E, Amenta F. Apathy in Alzheimer’s disease: any effective treatment. Sci World J. 2014.
6. Minter MR, Taylor JM, Crack PJ. The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease. J Neurochem. 2016; 136(3):457-74.
7. Alzheimer's Association: 2010 Alzheimer's disease facts and figures. Alzheimers Dement. 6: 158-194.
8. Abascal K, Yarnell E: Alzheimer's disease: part 2--A botanical treatment plan. Alternative and Complementary Therapies. 2004, 10: 67-72.
9. Kumar V: Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006, 20: 1023-1035.
10. Prince MJ. World Alzheimer Report the global impact of dementia: an analysis of prevalence, incidence, cost and trends. Alzheimer's disease International; 2015; London, UK.
11. Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S (2008) A standardized Withania somnifera extract significantly reduces stress-related parametersin chronically stressed humans: a double-blind randomized, placebo-controlled study. J Am Nutra Assoc 11:50-56.
12. Aswathy, Balasankar Karavadi, Nisha H. Homology Modeling and Docking Studies to Identify the Targets in Pancreatic Cancer. Research J. Pharm. and Tech. 2017; 10(7): 2032-2040.
13. Nisha H, Balasankar Karavadi, Aswathy. Computational Analysis to Identify the Drug Targets and their Lead Molecules in Pancreatic Cancer. Research J. Pharm. and Tech. 2017; 10(6): 1708-1716.
14. Howes MJ, Perry NS, Houghton PJ: Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res. 2003, 17: 1-18. 10.1002/ptr.1280.
15. Mishra LC, Singh BB, Dagenais S: Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000, 5: 334-346.
16. Matsuda H, Murakami T, Kishi A, Yoshikawa M: Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg Med Chem. 2001, 9: 1499-1507.
17. Aggarwal BB, Sundaram C, Malani N, Ichikawa H: Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007, 595: 1-75.
18. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA: Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther. 2008, 326: 196-208.
19. Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X (2015) Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodentmodel of intestinal ischemia reperfusion by inhibiting the pathway ofNF-Kb. Int J Clin Exp Pathol 8:3451-3459.
20. Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y et al. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS one. 2012; 7(3):32616.
21. Mishra S, Palanivelu K (2008) The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Ann Indian Acad Neurol 11:13-19.
22. G. V. Satyavati, M. K. Raina, and M. Sharma, Medicinal Plants of India, Indian Council of Medical Research, New Delhi, India, 1976.
23. Kumar V: Potential medicinal plants for CNS disorders: an overview. Phytother Res. 2006, 20: 1023-1035.
24. Bacopa monniera. Monograph. Altern Med Rev. 2004, 9: 79-85.
25. Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ: Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008, 22: 1629-1634. 10.1002/ptr.2537.
26. Parihar MS, Hemnani T: Phenolic antioxidants attenuate hippocampal neuronal cell damage against kainic acid induced excitotoxicity. J Biosci. 2003, 28: 121-128.
27. Bihaqi SW, Sharma M, Singh AP, Tiwari M: Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain. J Ethnopharmacol. 2009, 124: 409-415.
28. S.B. Prabha, Mohini Rao, M. R. Ramesh Kumar. Evaluation of in vitro Antioxidant, Antibacterial and Anticancer activities of leaf extracts of Cleome rutidosperma. Research J. Pharm. and Tech. 2017; 10(8): 2492-2496.
29. Venkatesh Kamath, Aravinda Pai, Rohith Raj. In Silico approach for the Rational Design of Tankyrase I Inhibitors–A Case Study on Flavone based Anticancer Leads. Research J. Pharm. and Tech 2018; 11(10): 4511-4514...
30. R.H. Singh, K. Narsimhamurthy, and G. Singh, “Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging,” Biogerontology, vol. 9, no. 6, pp. 369–374, 2008.
31. Nahata, U. K. Patil, and V. K. Dixit, “Effect of Convulvulus pluricaulis Choisy. On learning behaviour and memory enhancement activity in rodents,” Natural Product Research (Formerly Natural Product Letters), vol. 22, no. 16, pp. 1472–1482, 2008.32. Mani V, Milind P (2007) Memory enhancing activity of Emblica officinalis Gaertn: An ayurvedic preparation. Physiol Behav 91:46-54.
32. Ramachandran S, Sanjay S, Dhanaraju M (2013) Antiamnesic effect of Piracetam potentiated with Emblica officinalis and Curcuma longa in
33. Aluminium induced neurotoxicity of Alzheimer’s disease. Inter J AdvRes 1:185-196.
34. Godkar PB, Gordon RK, Ravindran A, Doctor BP (2006) Celastrus paniculatusseed oil and organic extracts attenuate hydrogen peroxideand
35. glutamate-induced injury in embryonic rat forebrain neuronalcells. Phytomedicine 13:29-36.
36. Godkar P, Gordon R, Ravindran A (2003) Celastrus paniculatus seedwater soluble extracts protect cultured rat forebrain neuronal cells
37. from hydrogen peroxide-induced oxidative injury. Fitoterapia74:658-669.
38. Bhanumathy M, Harish MS, Shivaprasad HN, Sushma G (2010) Nootropicactivity of Celastrus paniculatus seed. Pharm Biol 48:324-327.
39. Shinomol GK, Bharath MM: Exploring the role of 'Brahmi' (Bocopa monnieriand Centella asiatica) in brain function and therapy. Recent Pat Endocr Metab Immune Drug Discov. 2011, 5: 33-49.
40. Cervenka F, Jahodar L: [Plant metabolites as nootropics and cognitives]. Ceska Slov Farm. 2006, 55: 219-229. Article in Czech
41. Gujran S, Singh SP, Pal R, Singh S, Ram P, Nath C (2007) Gugulipid, anextract of Commiphora whighitti with lipid lowering properties, hasprotective effects against streptozotocin induced memory deficits inmice. Pharmacol Biochem Behav 8:797-805.
42. Raghad Dhyea Abdul Jalill. Chemical Analysis and Anticancer effects of Juniperuspolycarposand Oak Gall plants extracts. Research J. Pharm. and Tech 2018; 11(6): 2372-2387
43. Arvindganth. R, Anupriya K.V., Kathiravan. G. Enhancement of Anticancer Drug Annona muricata Against HT-29 Cell Line using Silver Nano Particles. Research J. Pharm. and Tech. 2017; 10(2): 529-532.
44. Anekonda TS, Hemachandra reddy P.can herbs provide a new generation of drugs for treating Alzheimer’s disease. Brain research review 2005;50:361-376
45. Buchwald-Werner S, Vazquez I. Effects of a Melissa officinalis special extract on mood and cognitive function. Planta Med. 2015; 81(16):SL5C_01.
46. Miraj S, Azizi N, Kiani S. A review of chemical components and pharmacological effects of Melissa officinalis L. Pharm Lett. 2016; 8(6):229-237.
47. Eidi M, Eidi A, Bahar M (2006) An effect of Salvia officinalis leaves onmemory retention and its interaction with the cholinergic system inrats. J Nut 22:321-326.
48. Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. J Tradit Complement Med. 2017; 7(4):433-440.
49. Akhondzadeh S, Noroozian M, Mohammadi M (2003b) Salvia officinalisextract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo-controlledtrial. J Clin Pharm Ther 28:53-59.
50. Chandrasekaran K, Mehrabian Z, Spinnewyan B, Drieu K, Kiskum G(2001) Neuroprotective effects of bilobalide, a component of Ginkgobiloba extract (EGb 761), in gerbil global brain ischemia. Brain Res922:282-292.
51. Shi C, Liu J, Wu F, Yew D (2010) Ginkgo biloba extract in Alzheimer’s disease: From action mechanisms to medical practice. Int J Mol Sci11:107-123.
52. Bastianetto S, Zheng WH, Quirion R (2000) The Ginkgo biloba extract(EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents andprotein kinase C. J Neurochem 74:2268-2277.
53. Nalini K, Aroor A, Karanth K, Rao A (1992) Centella asiatica fresh leafaqueous extract on learning and memory and biogenic amine turnoverin albino rats. Fitoterapia 63:232-233.
54. Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci. 2008; 73(1):R14-R19.
55. Mukesh Kumar D. J., Sonia K., Madhan R., Selvakumar K., Kalaichelvan P.T. Antiyeast, Antioxidant and Anticancer Activity of Tribulus terrestris Linn and Bougainvillea spectabilis Linn. Research J. Pharm. and Tech. 4(9): Sept. 2011;1483-1489.
56. Swarnalatha, Y. Isolation of Flavonoids and their Anticancer Activity from Sphaeranthusamaranthoides in A549 Cell Line. Research J. Pharm. and Tech. 8(4): April, 2015; Page 462-467 
57. Habtemariam S. The therapeutic potential of rosemary (Rosmarinus officinalis) diterpenes for Alzheimer’s disease. Evid Based Complementary Altern Med. 2016.
58. Saxena G, Singh SP, Pal R, Singh S, Pratap R, Nath C: Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. Pharmacol Biochem Behav. 2007, 86: 797-805.
59. Lyle N, Gomes A, Sur T, Munshi S, Paul S, Chatterjee S, Bhattacharyya D: The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome. Behav Brain Res. 2009, 202: 285-290.
60. Singh RH, Narsimhamurthy K, Singh G: Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology. 2008, 9: 369-374.
61. Malik J, Karan M, Vasisht K: Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi. Pharm Biol. 2011, 49: 1234-1242.
62. Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X (2015) Anti-inflammatoryand antioxidant effects of curcumin on acute lung injury in a rodentmodel of intestinal ischemia reperfusion by inhibiting the pathway ofNF-Kb. Int J Clin Exp Pathol 8:3451-3459.
63. John. D. Milton, M. Alvin Jose. Anticancer Activity of Ethyl Acetate Root Extract of Xanthiumstrumarium Linn. in N-Nitroso N-Methyl Urea Induced Mammary Carcinoma in Female Sprague-Dawley Rats. Research J. Pharm. and Tech 2016; 9(8):1115-1118.
64. L. Krishnasamy, M. Masilamani Selvam, Bharathi Ravikrishnan. Anticancer property of Colchicine isolated from Indigo feraaspalathoids. Research J. Pharm. and Tech. 2016; 9(4): 386-390.

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