Author(s): Janani Sadhasivam, Abimanyu Sugumaran, Damodharan Narayanaswamy


DOI: 10.5958/0974-360X.2020.00611.3   

Address: Janani Sadhasivam, Abimanyu Sugumaran*, Damodharan Narayanaswamy
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur 603203, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020

Recently, the progress in nanotechnology has led to the advancement of the delivery of drugs to the targeted site (TDDS). The introduction of Nano sponges has been an important step in conquering certain complications like toxicity of drug, its poor bioavailability, and release of medicament in a predictable manner. Currently, Nano sponges have achieved excellent impacts in delivering drugs through nanotechnology in which the nanosponges are porous in nature with tiny sponges (below 1 µm), circulating throughout the body. Therefore, they reach the target site and stick to the skin surface and release the drug in a controlled manner. A large variety of drugs can be encapsulated into the cavity of Nano sponges and it carries both hydrophilic and lipophilic drugs. Nano sponges (NSs) drug delivery system has been considered as one the most assuring field in pharmacy. It can be utilized as carrier for biocatalyst in the release of enzymes, vaccines, antibodies, and proteins. The current review focuses on the preparation method, evaluation and potential use in drug delivery system.

Cite this article:
Janani Sadhasivam, Abimanyu Sugumaran, Damodharan Narayanaswamy. Nano Sponges: A Potential Drug Delivery Approach. Research J. Pharm. and Tech. 2020; 13(7): 3442-3448. doi: 10.5958/0974-360X.2020.00611.3

Janani Sadhasivam, Abimanyu Sugumaran, Damodharan Narayanaswamy. Nano Sponges: A Potential Drug Delivery Approach. Research J. Pharm. and Tech. 2020; 13(7): 3442-3448. doi: 10.5958/0974-360X.2020.00611.3   Available on:

1. James R. Baker, Quintana A, Piehler L, Banazak-Holl M, Tomalia D , R E. The Synthesis and testing of anticancer therapeutic nanodevices. Biomedical micro devices. 2001; 3(1): 61- 69.
2. Kalyankar T. M., Butle S. R., Chamwad G. N. Application of Nanotechnology in Cancer Treatment. Research Journal of Pharmacy and Technology. 2012;5(9): 1161-1167.
3. Birajdar G.O, V.S. Kadam V.S, Chintale A.G, Halle P.D, Nabde M.K, Maske K.S. A Comprehensive Review on Nanotechnology. Research Journal of Pharmacy and Technology.2013; 6(5): 486-495.
4. Cheng Y, Morshed RA, Auffinger B, Tobias AL and Lesniak MS. Multifunctional nanoparticles for brain tumor imaging and therapy. Advanced Drug Delivery Reviews. 2014; 66: 42-57.
5. Subramanian S, Singireddy A, Krishnamoorthy K, Rajappan M. Nanosponges: A Novel drug delivery system-Review. Journal of Pharmacy and Pharmaceutical Sciences. 2012; 15(1): 103 -111.
6. Shringirishi M, Prajapati S.K, Mahor A, Alok S , Yadav P, Verma A. Nanosponges: a potential nanocarrier for novel drug delivery-a review. Asian Pacific Journal of Tropical Disease. 2014; 4(Suppl 2): 519-526.
7. Yadav G, Panchory HP. Nanosponges–a boon to the targeted drug delivery system. Journal of Drug Delivery & Therapeutics. 2013; 3(4): 151-5.
8. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges.2007; Euroean Patent 1 786 841 B1.
9. Bezawada S, Charanjitha, Reddy V.M, Naveena, Gupta V.R. Nanosponges- A Concise Review For Emerging Trends. International Journal of Pharmaceutical Research and Biomedical Analysis. 2014; 3(1): 1-6.
10. Bhowmik H, Venkatesh DN, Kuila A, Kumar KH. Nanosponges: A Review. International Journal of Applied Pharmaceutics. 2018;10(4):1-5.
11. David F. Nanosponge drug delivery system more effective than direct injection. 2010; from
12. Jenny A, Merima P, Alberto F, Francesco T. Roleof β- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86(1):127– 135.
13. Subramanian S. Multifunctional Nanosponges for the Treatment of Cancer- A Review. Journal of Pharmaceutical Sciences & Research. 2017;9(12):2661-2668.
14. Thakre AR, Gholse YN, Kasliwal RH. Nanosponges: a novel approach of drug delivery system. Journal of Medical Pharmaceutical and Allied Sciences. 2016;78:103-11.
15. Lala R, Thorat A, Gargote C. Current trends in β- cyclodextrin based drug delivery systems. International Journal of Research Ayurveda and Pharmacy, 2011; 2(5): 1520-1526.
16. Ahmed RZ, Patil G, Zaheer Z. Nanosponges–a completely new nano-horizon: pharmaceutical applications and recent advances. Drug Development and Industrial Pharmacy. 2013; 39(9): 1263-72.
17. Jilsha G, Viswanand V. Nanosponge A Novel Approach of Drug Delivery System. International Journal of pharmaceutical Science Review And Research 2013; 19(2): 119-123.
18. Balasaheb M. T, Patil P. M, Jahagirdar A. C, Khandekar D. B. Nanosponge An Emerging Drug Delivery System. International Journal of Institutional Pharmacy and Life sciences.2015;5(6).
19. Vishwakarma A, Nikam P, Mogal R, Talale S. Nanosponges: A Benifiaction for Novel drug Delivery system. International Journal of Pharm. Tech Sciences.2014; 6(1):11-20.
20. Patel E. K, Oswal R. J. Nanosponge and Micro Sponges: A Novel Drug Delivery System. International Journal of Research In Pharmacy And Chemistry. 2012; 2(2): 237-244.
21. Nilesh J, Ruchi J, Navneet T, Braham Prakash G, Deepak Kumar J. Nanotechnology: A Safe and Effective Drug Delivery Systems. Asian Journal of Pharmaceutical and Clinical Research. 2010; 3(3):159-165.
22. Singh D, Soni GC, Prajapati SK. Recent advances in nanosponges as drug delivery system: a review. Euroean Journal of Pharmaceutical and Medical Research 2016;3(10):364-71.
23. Rahi, N.; Kumar, K. 2017. Nanosponges: A new era of versatile drug delivery system. Univ. J. Pharm. Res., 2(3), 31-5. DOI: 10.22270/ujpr.v2i3.RW4
24. Dubey, P.; Sharma, H.K.; Shah, S.; Tyagi, C.K.; Chandekar, A.K.; Jadon, R.S. 2017.Formulations and evaluation of cyclodextrin complexed cefadroxil-loaded nanosponges. Int. J. Drug Del., 9(3), 84-100. DOI: 10.5138/09750215.2180
25. Kundlas J, Nautiyal ., Jassal M. Nanosponges: As Originated Form For Targeted Drug Delivery. International Journal of Recent Advances In Pharmaceutical Research. 2015; 5(2): 75-81.
26. Setijadi E, Tao L, Liu J, Jia Z, Boyer C, Davis TP. Biodegradable star polymers functionalized with betacyclodextrin inclusion complexes. Biomacromolecules. 2009; 10(9):2699-707.
27. Cavalli R, Rogero CM, Mognetti B, Berta GN, Tumiatti V, Trotta F. Cyclodextrin-based nanosponges as a vehicle for antitumoral drugs. WO 2009/003656 A1. 2009.
28. Arshad Ahmed Khan K. Nanosponges: A New Approach for Drug Targetting. International Journal of Pharmacy and Pharmaceutical Research. 2016; 7(3): 381-96.
29. Patil T.S, Nalawade N.A, Kakade V.K, Kale S.N. Nanosponges: A novel targeted drug delivery for cancer treatment. International Journal of Advance Research and Development. 2017; 2(4): 55-62.
30. Osmani R.A, Thirumaleshwar S, Bhosale R.R, Kulkarni P.K. Nanosponges: The spanking accession in drug delivery- An updated comprehensive review. Der. Pharmacia Sinica. 2014; 5(6): 7-21.
31. Sharma R, Pathak K. Nanosponges: Emerging drug delivery system. Pharma Stud. 2010; 33-5.
32. Sharma R, Roderick B, and Pathak K. Evaluation of kinetics and mechanism of drug release from Econazole nitrate Nanosponges loaded carbopol Hydrogel. Indian Journal of Pharmaceutical Education and research. 2011; 45(1):25-31.
33. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Euroean Journal of Pharmaceutics and Biopharmaceutics. 2010; 74(2): 193-201.
34. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes –A Review. Journal of Pharmaceutical Science and Technology. 2010; 2(3):171-183.
35. Rosalba M, Roberta C, Roberto F, Chiara D, Piergiorgio P, Leigh E, Li S, Roberto P. Antitumor activity of nanosponge-encapsulated Camptotechin in human prostate tumors. Cancer Research. 2011; 71(8):4431.
36. Moura FC, Lago RM. Catalytic growth of carbon nanotubes and nanofibers on vermiculite to produce floatable hydrophobic “nanosponges” for oil spill remediation. Applied Catalysis B. 2009; 90(3-4): 436-40.
37. Singh R, Bharti N, Madan J, Hiremath SN. Characterization of cyclodextrin inclusion complexes-a review. Journal of Pharmaceutical Science and Technology. 2010; 2(3) :171-83.
38. Emanuele A, Dinarvand R. Preparation, Characterization and Drug Release from Thermoresponsive Microspheres. International Journal of Pharmaceutics.1995; 118(2) : 237-42.
39. Boscolo B, Trotta F, Ghibaudi E. High catalytic performances of Pseudomonas fluorescens lipase adsorbed on a new type of cyclodextrin-based nanosponges. Journal of Molecular Catalysis B: Enzymatic. 2010; 62(2):155-61.
40. Farooq SA, Saini V. Application of novel drug delivery system in the pharmacotherapy of hyperlipidemia. Journal of Chemistry and Pharmaceutical Sciences.2013; 6(3):138-46.
41. Shende P, Kulkarni Y.A, Gaud R.S, Cavalli R, Ttrotta F, Deshmukh K, Caldera F. Acute and repeated dose toxicity studies of different β-cyclodextrin-based nanosponge formulation. Journal of Pharmaceutical Sciences. 2015; 104(5): 1856–63.
42. Renuka S, Roderick BW, Kamla P. Evaluation of the kinetics and mechanism of drug release from Econazole Nitrate nanosponge loaded carbapol hydrogel. Indian Journal of Pharmaceutical Education and Research. 2011; 45(1): 2531.
43. Renuka S, Kamla P. Polymeric nanosponges as an alternative carrier for improved retention of econazole nitrate onto the skin through topical hydrogel formulation. Pharmaceutical Development and Technology. 2011; 16(4):367-376.
44. Gilardi G, Trota F, Cavalli R, Ferruti P, Ranucci E, Di Nardo G, Roggero C, Tumiatti V. Cyclodextrin nanosponges as carrier for biocatalysts, and in the delivery and release of enzymes, proteins, vaccines and antibodies. WO2009149883 A1; 2009.
45. Che-Ming J Hu, Ronnie H Fang, Jonathan Copp, Brian T Luk, Liangfang Zhang. A biomimetic nanosponge that absorbs pore forming toxins. Nature Nanotechnology. 2013; 8:336–40.
46. Appell M, Jackson M.A. Sorption of Ochratoxin A from aqueous solutions using β cyclodextrin-polyurethane polymer. Toxins. 2012; 4(2), 98-109.
47. Shivani S, Poladi K.K. Nanosponges -A novel emerging drug delivery system: A review. International Journal of Pharmaceutical Science and Research .2015; 6(2), 529-40.
48. Trotta F, Zanetti M, Cavalli R. Cyclodextrin-based nanosponges as drug carriers. Beilstein Journal of Organic Chemistry. 2012; 8, 2091-9.
49. Ansari K.A, Torne S, Vavia P.R, Trotta F, Cavalli R. Cyclodextrin - Based Nanosponges for Delivery of Resveratrol: In Vitro Characterization, Stability, Cytotoxicity and Permeation Study. AAPS Pharm Sci Tech. 2011; 12, (1): 279-86.
50. Trotta F. Cyclodextrin Nano sponges and their applications. Cyclodextrins in pharmaceutics, cosmetics, and biomedicine. Current and Future Industrial Applications. 2011; 323-42.
51. Kaur G, Aggarwal G, Harikumar SL. Nanosponge: New colloidal drug delivery system for topical delivery. Indo Global Journal of Pharmaceutical Sciences. 2015; 5(1):53-7.
52. Kadian R. Nanoparticles: a promising drug delivery approach. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(1):30-5.
53. Pawar S, Shende P, Trotta F. Diversity of β-cyclodextrin-based nanosponges for transformation of actives. International Journal of Pharmaceutics. 2019; 565(1):333-350.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available