Author(s): Sukma Sahadewa, Djanggan Sargowo, Muhammad Aris widodo, HMS Chandra Kusuma

Email(s): sukmasahadewa1717@gmail.com

DOI: 10.5958/0974-360X.2020.00606.X   

Address: Sukma Sahadewa1,2*, Djanggan Sargowo3, Muhammad Aris widodo4, HMS Chandra Kusuma5
1Doctoral Program of Medical Science, Medical Faculty, Universitas Brawijaya, Malang, East Java, Indonesia.
2Department of Public Health, Medical Faculty, Universitas Wijaya Kusuma, Surabaya, East Java Indonesia.
3Cardiology and Vascular Medicine Department, Faculty of Medicine, Brawijaya University Malang, Indonesia.
4Department of Pharmacology, Faculty of Medicine, University Brawijaya Malang, East Java, Indonesia.
5Laboratory of Pediatris, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
Objective: to examine the role of zinc supplementation on the level of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis Wistar rats Methods: This is a pure experimental study (true experimental laboratory) which was carried out in a laboratory in vivo by using a post-test control group design with the subjects were male Wistar (Rattus norvegicus) rats aged 2-3 months, obtained from the PUSVETNA unit (Surabaya). Results: Significant differences were found in levels of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis male wistar rats compared with the control group. Conclusion: This study found the ability of Zinc in reducing levels of oxidative stress in patients with tuberculosis and the function of Zinc in modulating the immune system. However in the actual clinical situation it is necessary to consider other comorbid conditions.


Cite this article:
Sukma Sahadewa, Djanggan Sargowo, Muhammad Aris widodo, HMS Chandra Kusuma. The Role of Zinc Supplementation on the level of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis Wistar rats. Research J. Pharm. and Tech. 2020; 13(7): 3409-3413. doi: 10.5958/0974-360X.2020.00606.X


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