Author(s): S. Karthika, N. Kannappan, TNK Suriyaprakash

Email(s): karthikaselvam1990@gmail.com

DOI: 10.5958/0974-360X.2020.00595.8   

Address: S. Karthika1, N. Kannappan2, TNK Suriyaprakash1
1Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Ponthavannam P.O, Perinthalmanna, Kerala-679325.
2Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu-608002.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
Amyloid-beta peptide (Aß) is implicated in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder. The present study was designed to determine the effect of two medicinal plants used to treat neurodegenerative diseases on Amyloid beta intoxicated SHSY5Y cell line. Cytotoxicity of the different extracts of the two medicinal plants was determined against SH-SY5Y (human neuroblastoma) cells which were untreated, as well as toxically induced with Aß, using the MTT assay. The n-Hexane extract of Hydrocotyle javanica (HJ) and Alcoholic extract of Peristrophe bicalyculata (PB) were the least toxic to the SH-SY5Ycells at the highest concentration tested (250µg/ml). All different extracts of two medicinal plants tested were observed to reduce the effects of Aß-induced neuronal cell death, indicating that they may contain compounds which may be relevant in the prevention of AD progression.


Cite this article:
S. Karthika, N. Kannappan, TNK Suriyaprakash. Effect of Medicinal plants on amyloid β1-42 Intoxicated SH-SY5Y cell Lines - As Neuroprotective Evaluation. Research J. Pharm. and Tech. 2020; 13(7): 3351-3355. doi: 10.5958/0974-360X.2020.00595.8


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