Author(s): V. M. Chushenko, T. G. Yarnykh, G. B. Yuryeva, I. V. Herasymova

Email(s): iryna_herasymova@ukr.net

DOI: 10.5958/0974-360X.2020.00593.4   

Address: V. M. Chushenko, T. G. Yarnykh, G. B. Yuryeva, I. V. Herasymova
Technology of Drugs Department, National University of Pharmacy, 61002, Pushkinskaya St. 53, Kharkiv, Ukraine.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
Purpose. The aim of the study is to create of cocoa butter bases for the preparation of suppositories in pharmacy condition with a various active pharmaceutical ingredients by casting method, which is hygienic, convenient, fast and efficient. Methods. In the process, we used physical-chemical and pharmaco-technological methods of researches to study the basic properties of suppositories. Results. The conditions for the creation of cocoa butter bases with various emulsifiers for the manufacture of suppositories in pharmacy condition by the casting method have been studied. The ratio between the cocoa butter and emulsifiers at which it is possible to prepare suppository bases has been established. Conclusions. Based on the conducted research a cocoa butter bases with emulsifiers have been developed. Suppositories prepared by casting method were compatible with the requirements to suppository bases of the State Pharmacopoeia of Ukraine 2.0.


Cite this article:
V. M. Chushenko, T. G. Yarnykh, G. B. Yuryeva, I. V. Herasymova. Creation of Cocoa butter bases for preparation of suppositories in pharmacy condition by the casting method. Research J. Pharm. and Tech. 2020; 13(7): 3343-3346. doi: 10.5958/0974-360X.2020.00593.4


REFERENCES:
1. State Pharmacopoeia of Ukraine. Scientifical Pharmacopoeia center, 2 App., Kh.: RІRЕG. 2015; Vol. 1:716-723.
2. Yarnykh TG, Tykhonov OI, Gryzodub OI, Chushenko VM, Levachkova Yu. Technology of rectal suppositories and pessaries “ex tempore” - proposals for the supplement of the general monograph of SPU 5.N.1 Ex tempore drugs. Pharmakom. 2010; 1:64-78.
3. State Pharmacopoeia of Ukraine: Suppositories and pessaries made in pharmacies. Scientifical Pharmacopoeia center. 2 App. Kh.: RІRЕG. 2014; 716-723.
4. Orlova TV, Pankrusheva TA. Choosing of Suppository Bases in Suppository Technology. Pharmacy. 2014; 1:34-38.
5. Tykhonov OI. Chemist’s technology of drugs, 4th edn, New Book, Vinnytsia. 2016.
6. Yarnykh TG, Tolochko KV, Chushenko VM. Study of the range of suppository bases (review). Chemical and Pharmaceutical Journal. 2010; 44(10):21-26.
7. European Pharmacopoeia, 5 th ed., Strasbourg, Council of Europe. 2005.
8. USP Pharmacists' Pharmacopeia, The United State Pharmacopeial, Inc., Rockville. 2008.
9. Yarnykh TG, Levachkova YuV, Buryak MV, Kubrina NV. Basics of Suppository Technology - Extemporal Preparation. Pharmacy. 2010; 2:54-56.
10. Yarnykh TG, Tolochko KV, Chushenko VM. Basis for suppositories. Patent for utility model № 69000 Ukraine, Public. 25.04.2012, Bul. № 8.

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