Author(s): Zeena Fernandes, Prasanna Shama Khandige, Ullas Prakash D’Souza

Email(s): Prasannasham@nitte.edu.in

DOI: 10.5958/0974-360X.2020.00590.9   

Address: Zeena Fernandes, Prasanna Shama Khandige*, Ullas Prakash D’Souza
Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Paneer, Derlakatte P.O, Mangaluru-574160 India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
The present study was undertaken to evaluate the anti-anxiety activity of the ethanolic and aqueous extract of Perseaamericana bark by the elevated plus maze method using swiss albino mice. The anti-anxiety activity of the ethanolic and aqueous extracts at doses 100, 200 and 400mg/kg body weight, was evaluated using the elevated plus maze method. Diazepam (0.5mg/kg) was used as the standard drug for comparison. In this study the ethanolic and the aqueous extract (200mg/kg and 400mg/kg) showed significant increase in the following parameters: % number of open arm entries and % time spent in open arms in Elevated Plus maze method. From the present study it can be concluded that Perseaamericana bark showed a significant anti-anxiety activity.


Cite this article:
Zeena Fernandes, Prasanna Shama Khandige, Ullas Prakash D’Souza. Anxiolytic potential of Perseaamericana M. by elevated plus maze test. Research J. Pharm. and Tech. 2020; 13(7): 3326-3328. doi: 10.5958/0974-360X.2020.00590.9


REFERENCES:
1. Fernandes Z, D’souza U. In Vitro Anti Inflammatory Activity on the ethanolic bark extract of Perseaamericana M. Research J.Pharm.Tech.2018;11(12):5517-5519.
2. Kulkarni SK, Reddy DS. Animal behavioural models for testing antianxiety agents. Method Findings Exp Clin Pharmacol.1996; 18: 219–230.
3. Pellow S, Chopin P, File SE, Briley M .Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985; 14: 149–176
4. Calatayud F, Belzung C, Aubert A. Ethological validation and the assessment of anxiety-like behaviours: Methodological comparison of classical analyses and structural approaches. Behav Processes. 2004; 67:195–206.
5. Hoggs S. A review of the validity and variability of the elevated plus maze as an animal model of anxiety. Pharmacol Biochem Behav. 1996; 54: 21–30.

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