Author(s): Manasiya Almijan Mahmad, Babitha S, Tejaskumar H, Pooja T, Veeresh Prabhakar Veerapur

Email(s): babithamurthy@gmail.com

DOI: 10.5958/0974-360X.2020.00588.0   

Address: Manasiya Almijan Mahmad1, Babitha S1*, Tejaskumar H1, Pooja T1, Veeresh Prabhakar Veerapur2
1Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka.
2Department of Quality Assurance, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
The present study was undertaken to explore the hepatoprotective potential of fresh fruit juice of Opuntia dillenii Haw. (FJOD) against paracetamol (PCM) induced hepatotoxicity in rats. Protective effect was evaluated by measuring the physical parameters like wet liver weight and liver volume, serum levels of hepatic biomarkers, hepatic levels of oxidative stress parameters along with histopathological observations. The rats were allocated into six groups, of six animals per group. Rats were orally treated with fresh fruit juice of O. dillenii (2.5 ml/kg and 5 ml/kg) and Silymarin (100 mg/kg) for 7 days. Rats were intoxicated on 5th day with PCM (2 g/kg, p.o.). After 7 days treatment, rats were anesthetized to withdraw blood and further sacrificed to collect liver and processed to assess parameters of liver and oxidative stress. The O. dillenii showed significant hepatoprotective activity by decreasing the levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin levels. Similarly, significantly preserved levels of hepatic catalase (CAT), glutathione (GSH) and diminished contents of lipid peroxidation (LPO) were observed. Histopathological changes due to paracetamol intoxication were either partly or fully prevented in rat liver tissues pre-treated with fresh fruit juice of Opuntia dillenii. The present study suggests that fresh fruit juice of O. dillenii possess significant hepatoprotective activity against paracetamol induced hepatotoxicity in rats. This activity could be probably through its antioxidant potential.


Cite this article:
Manasiya Almijan Mahmad, Babitha S, Tejaskumar H, Pooja T, Veeresh Prabhakar Veerapur. Fresh fruit juice of Opuntia dillenii Haw attenuates paracetamol induced hepatotoxicity in rats. Research J. Pharm. and Tech. 2020; 13(7): 3317-3322. doi: 10.5958/0974-360X.2020.00588.0


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