Author(s): Divya B, Shivashree S, K. Mruthunjaya, S. N. Manjula

Email(s): snmanjula@jssuni.edu.in , Shivashree.shree@gmail.com

DOI: 10.5958/0974-360X.2020.00581.8   

Address: Divya B1, Shivashree S1, K. Mruthunjaya2, S. N. Manjula2*
1Department of Pharmacology, JSS College of Pharmacy JSS Academy of Higher Education and Research, Mysore-570015, Karnataka, India.
2Department of Pharmacognosy, JSS College of Pharmacy JSS Academy of Higher Education and Research, Mysore-570015, Karnataka, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
Doxorubicin (DOX) is widely used in the treatment of various human neoplasms. The development of severe undesirable effects such as cardiotoxicity, myelotoxicity, GI Toxicity limits its therapeutic efficacy. The present study explores the beneficial effect of alcoholic extract of roots of Lawsonia inermis (LIALC) against doxorubicin induced cardiotoxicity and also to assess the antitumor efficacy of the combination treatment on tumor bearing mice. Cardiotoxicity was evaluated by measuring serum biomarkers glutamic oxalo transaminase (GOT), glutamic Pyruvic transaminase (GPT), alkaline phosphatase (ALP), creatinine and urea and cardiac antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and lipid peroxidation (LP) in heart homogenate. After treatment with extract for 2 weeks in doxorubicin intoxicated mice, the antitumor activity of combined treatment was determined by mean survival time. Toxicity was evidenced by increased levels of serum biomarkers and decreased levels of cardiac antioxidant enzymes. Treatment with extract provided substantial protection by altering the above parameters to near normal level and prolonging the survival time of tumorous mice. However these results suggest that extract of roots of Lawsonia inermis has the ability to reduce cardiotoxicity and ameliorate doxorubicin antitumor effect.


Cite this article:
Divya B, Shivashree S, K. Mruthunjaya, S. N. Manjula. Cardioprotective activity of Lawsonia inermis roots against Doxorubicin Treated Mice. Research J. Pharm. and Tech. 2020; 13(7): 3279-3283. doi: 10.5958/0974-360X.2020.00581.8


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