Author(s): Majed Jary Mohammed, Zeyad Kadhim Oleiwi, Muntadher Abdulabbas Hasan Al-Hilo, Ahmed Kareem Hussein Mubarak, Ehab Kareem Obaid, Ali Jabbar Radhi

Email(s): Alijebar56@gmail.com

DOI: 10.5958/0974-360X.2020.00577.6   

Address: Majed Jary Mohammed1, Zeyad Kadhim Oleiwi2, Muntadher Abdulabbas Hasan Al-Hilo3, Ahmed Kareem Hussein Mubarak4, Ehab Kareem Obaid5, Ali Jabbar Radhi2*
1College of Science, University of Kufa, Najaf, Iraq.
2College of Pharmacy, University of Al-Kafeel, Najaf, Iraq.
3College of Health and Medical Techniques, University of Al-Kafeel, Najaf, Iraq.
4College of Pharmacy, University of Kufa, Najaf, Iraq.
5College of Agriculture, Al-Qasim Green University, Babylon, Iraq.
*Corresponding Author

Published In:   Volume - 13,      Issue - 7,     Year - 2020


ABSTRACT:
A series of 1,2,3-triazole and tetrazole derivatives have been synthesized by CuCl catalyzed cyclo addition reaction among 2-azido gemcitabine and compounds contain triple bond in their structure, alkyne and nitrile derivatives in DMF. The structures of the prepared compounds were analyzed by FTIR and 13C and 1H NMR spectroscopic techniques. The heterocyclic compounds screened against two types of bacteria are G-ve and G +ve bacteria, Escherichia coli, Staphylococcus aureus and Streptococcus pneumonia, using Azithromycin as control drug.


Cite this article:
Majed Jary Mohammed, Zeyad Kadhim Oleiwi, Muntadher Abdulabbas Hasan Al-Hilo, Ahmed Kareem Hussein Mubarak, Ehab Kareem Obaid, Ali Jabbar Radhi. Synthesis and Study Biological Activity of Gemcitabine Linked Heterocyclic Hybrids. Research J. Pharm. and Tech. 2020; 13(7): 3257-3261. doi: 10.5958/0974-360X.2020.00577.6


REFERENCES:
1. Eckel, F.; Schneider, G.; Schmid, R. M. Pancreatic cancer: a review of recent advances. Expert Opin. Invest. Drugs 2006, 15, 1395–1410.
2. Heinemann, V. Gemcitabine in metastatic breast cancer. Expert Rev. Anticancer Ther. 2005, 5, 429–443.
3. Tripathy, D. Overview: gemcitabine as single-agent therapy for advanced breast cancer. Clin. Breast Cancer, 2002, 3, 8–11.
4. Abbass, A.F., Zimam, E.H., Synthesis, characterization and study biological activity of some new pyrimidine and 1, 2, 3, 4-tetrazole derivatives based on sulfadiazine, International Journal of Chem Tech Research, 2016,9, 206-217.
5. Lwahab Alkuwaity, E.A.; Hussein Zimam, E. Synthesis and biological activity of some new heterocyclic compounds from D-Mannitol. Der Pharma Chemica. 2016,8, 29-39.
6. Ahmed W. R., Synthesis, characterization and Study biological activity of 1, 2, 3-triazoline derivatives of sulfadiazine, International Journal of Current Research, 2017, 9, 8, 55649-55653.
7. Ali Jabbar Radhi, Ezzat H. Zimam, Emad Abbas Jaffar Al-Mulla, Synthesis of some novel barbital derivatives based on Carbohydrate as α-glucosidase inhibitors, Research J. Pharm. and Tech. 2019; 12(3): 1145-1154.
8. Farked Wahoodi Salman, Ahmed Jasim Twayej, Hayder Ahmed Shaheed, Ali Jabbar Radhi, New Gemcitabine Derivatives as potent in vitro α-Glucosidase Inhibitors, Nano Biomed. Eng., 2019,11(1): 84-90.
9. Zeyad Kadhem oleiwi; PhD. Thesis, Faculty of Science, University of Kufa, 2015.
10. Khdur, R.A.; Zimam, E.H.; Synthesis and characterization of some new β-lactam derivatives from Azo sulphadiazine and its biological evaluation as anticancer. Oriental Journal of Chemistry. 2018,34,371-380.

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