Vitamin E (alpha-tocopherol) has an anti-aging role and can protect the biologic membrane damage from free radicals. Vitamin E is highly lipophilic and has low stability, therefore to improve its effectiveness it is necessary to select appropriate carriers. Nanoemulsion is a drug delivery system in the form of aqueous oil dispersion stabilized by a combination of surfactants and co-surfactants that having droplet size 20-600 nm. Objective: This research aimed to prepare and to evaluate the physical characteristics of vitamin E nanoemulsion. Preparation of vitamin E nanoemulsion using phase oil of VCO (Virgin Coconut Oil) and Olive Oil. Method: The preparation of vitamin E nanoemulsion was performed by a combination of a low energy emulsification method with a magnetic stirrer and a method with high energy emulsification with a sonicator. The parameters of the nanoemulsion formula include organoleptic, pH, nanoemulsion type, percent transmittance, as well as the size and distribution of droplets. Results: The results showed that the composition of the optimum formula of nanoemulsion vitamin E using VCO as oil phase consists of 2% VCO, 24% tween 80 and 6% PEG 400. The optimum formula was transparent, homogeneous, pH 6.19, nanoemulsion type of oil in water, transmittance percentage 98.7%, droplet size 11.9 nm, polydispersity index 0.023. The composition of the optimum formula of nanoemulsion vitamin E using olive as oil phase consists of 2% olive oil, 18-24% tween 80 and 6% PEG 400.The optimum formula was transparent, homogeneous, pH 6.46 and 6.29, nanoemulsion type of oil in water, transmittance percentage 100%, droplet size 13.2 nm and 10.4 nm, polydispersity index 0.004 and 0.034.
Cite this article:
Suryani, Muhamad Handoyo Sahumena, Sry Yusti Mabilla, Rahmi Ningsih, Andi Nafisah Tendri Adjeng, Muhammad Aswan, Ruslin, Yamin, Michrun Nisa. Preparation and Evaluation of Physical Characteristics of Vitamin E Nanoemulsion using virgin coconut Oil (VCO) and olive oil as oil phase with variation Concentration of tween 80 Surfactant. Research J. Pharm. and Tech. 2020; 13(7): 3232-3236. doi: 10.5958/0974-360X.2020.00572.7
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