Venkatasathya Sai Appala Raju Velaga, Nagaraja Suryadevara, Ricca Tai Ching Ying, Ponmurugan P, Gokila Devi
Venkatasathya Sai Appala Raju Velaga1, Nagaraja Suryadevara2*, Ricca Tai Ching Ying1, Ponmurugan P3, Gokila Devi4
1Faculty of Pharmacy, MAHSA University, Malaysia.
2Department of Biomedical Sciences, Faculty of Medicine, MAHSA University, Malaysia.
3Biomedical Research Lab, Department of Botany, Bharathiar University, Coimbatore – 641046, Tamil Nadu, India.
4Department of Biotechnology, Nandha College of Arts and Sciences, Erode, Tamilnadu, India.
Volume - 13,
Issue - 7,
Year - 2020
Pain affects millions of people and often causes major health problems. Often opioid analgesic or NSAIDs are prescribed to relief pain but for long term use can cause various adverse effects which lead to the necessity to discover a potential analgesic compound. There is lack of scientific evidence on the Annona squamosa analgesic property with the relationship of the phytochemical constituents. As a preliminary study which aims to evaluate the potential analgesic property of Annona squamosa Linnaeus fruit’s peel and leaves extract by using mice. The fruit peel and leaves coarse powder was underwent extraction process using petroleum ether, chloroform and ethanol as solvent extract for 24 hours. The extracts were evaluated for presence of the phytochemical components. Each extracts were tested for tail flick immersion test and acetic acid induced writhing method for both central and peripheral analgesic evaluation by using Albino mice. The test extract and standard analgesic drug (tramadol, and diclofenac sodium) were compared for analgesic activity. In conclusion, it was suggested that the crude 50 mg/kg ethanolic fruit peel extract showed the most significant centrally and peripherally acting analgesic activity compared to other test extracts. It showed the presence of various phytochemical constituents such as alkaloids, tannins or phenolic compounds, flavanoids, phytosterol, and glycosides contributes to the analgesic and possess anti-nociceptive activity.
Cite this article:
Venkatasathya Sai Appala Raju Velaga, Nagaraja Suryadevara, Ricca Tai Ching Ying, Ponmurugan P, Gokila Devi. Analgesic activity of Annona squamosa Linn fruit peels on Swis Albino mice. Research J. Pharm. and Tech. 2020; 13(7): 3199-3204. doi: 10.5958/0974-360X.2020.00566.1
Venkatasathya Sai Appala Raju Velaga, Nagaraja Suryadevara, Ricca Tai Ching Ying, Ponmurugan P, Gokila Devi. Analgesic activity of Annona squamosa Linn fruit peels on Swis Albino mice. Research J. Pharm. and Tech. 2020; 13(7): 3199-3204. doi: 10.5958/0974-360X.2020.00566.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-7-26
1. Vyas, K., Manda, H., Sharma, R.K. and Singhal, G. 2012, An updated review on Annona squamosa, International Journal of Pharmacy and Therapeutics. 3(2), 107-118.
2. Gajalakshmi, S., Divya D.V., Mythill, S. and Sathiavelu. A, Pharmacological activities of Annona squamosa: a review, International Journal of Pharmaceutical Sciences Review and Research. 2(10):24-29.
3. Pandey, N. and Barve, D. 2011, Phytochemical and pharmacological review on Annona squamosa Linn. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2(4): 1404.
4. Chavan, M.J., Wakte, P.S and Shinde, D.B. 2010, Analgesic and anti-inflammatory of caryophyllene oxide of Annona squamosa Linn. bark, Phytomedicine Science Direct. 17: 149-151.
5. Singh, T., Rakesh, S. and Malik, P. 2014, Analgesic and anti-inflammatory activity of Annona squamosa Linn. bark, Journal of Scientific and Innovative Research. 3(1): 60-64.
6. Debnath 2011, Phytochemical and Pharmacological evaluation of the seeds of Annona squamosa Linn, International Journal of Pharmacy and Pharmaceutical Sciences. 4(3): 92-94.
7. Gowdhami, Sarkar, B.L. and Ayyasamy P.M. 2014, Screening of phytochemicals and antibacterial activity of Annona squamosa extracts, International Journal of Pharmaceutical Science Invention. 3(7): 30.
8. Dewasya, P.S., Brijeshkunvar, M. and Richa, M. 2012, Antinociceptive and anti-inflammatory of Annona squamosa L. leaf extract in rats and mice, Research Journal Pharmacognosy and Phytochemistry. 4(3): 182-185.